Regional brain activation during proximal stomach distention in humans: A positron emission tomography study

Vandenbergh, Joris; Dupont, Patrick; Fischler, Benjamin; Bormans, Guy; Persoons, Philippe; Janssens, Jozef; Tack, Jan

doi:10.1053/j.gastro.2004.11.054

Cited by 109 publications

(118 citation statements)

References 59 publications

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“…To date, the majority of human studies in this field have used distension of the rectosigmoid colon [4,5,8,41,44,48,52,62], stomach [37,69], and esophagus [2,3,9,73]. Activation of the insular and dorsal anterior cingulate cortex (dACC) has been most consistently reported, with other brain regions, including the prefrontal cortex, thalamus and brainstem being reported in some, but not in other studies.…”

Section: Introductionmentioning

confidence: 99%

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Wang

Bradesi

Maarek³

et al. 2008

Pain

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Preclinical drug development for visceral pain has largely relied on quantifying pseudoaffective responses to colorectal distension (CRD) in restrained rodents. However, the predictive value of changes in simple reflex responses in rodents for the complex human pain experience is not known. Male rats were implanted with venous cannulas and with telemetry transmitters for abdominal electromyographic (EMG) recordings. [ 14 C]-iodoantipyrine was injected during noxious CRD (60 mmHg) in the awake, nonrestrained animal. Regional cerebral blood flow (rCBF)-related tissue radioactivity was quantified by autoradiography and analyzed in the threedimensionally reconstructed brain by statistical parametric mapping. 60-mmHg CRD, compared with controls (0 mmHg) evoked significant increases in EMG activity (267 ± 24% vs. 103 ± 8%), as well as in behavioral pain score (77 ± 6% vs. 3 ± 3%). CRD elicited significant increases in rCBF as expected in sensory (insula, somatosensory cortex), and limbic and paralimbic regions (including anterior cingulate cortex and amygdala). Significant decreases in rCBF were seen in the thalamus, parabrachial nucleus, periaqueductal gray, hypothalamus and pons. Correlations of rCBF with EMG and with behavioral pain score were noted in the cingulate, insula, lateral amygdala, dorsal striatum, somatosensory and motor regions. Our findings support the validity of measurements of cerebral perfusion during CRD in the freely moving rat as a model of functional brain changes in human visceral pain. However, not all regions demonstrating significant group differences correlated with EMG or behavioral measures. This suggests that functional brain imaging captures more extensive responses of the central nervous system to noxious visceral distension than those identified by traditional measures.

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Section: Introductionmentioning

confidence: 99%

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Wang

Bradesi

Maarek³

et al. 2008

Pain

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“…Our results revealed decreased right insular connectivity with the right SFG and anterior mid-cingulate cortex (aMCC). While decreased connectivity with the right SFG was also associated with greater levels of trait anxiety, decreased connectivity with the aMCC, a region implicated in body awareness (Medford and Critchley, 2010;Vandenbergh et al, 2005), was uniquely related to awareness of unusual bodily sensations. As interoceptive awareness has been found to mediate the relationship between trait anxiety and the intensity of unpleasant feelings (Pollatos et al, 2007), our results raise the possibility that MDMA might attenuate unpleasant feelings-and conversely produce its characteristic positive feelings (Liechti and Vollenweider, 2000)-by decreasing the integrity of a neural network important for encoding trait anxiety and supporting interoceptive awareness.…”

Section: Discussionmentioning

confidence: 94%

Altered Insula Connectivity under MDMA

Walpola

Nest

Roseman

et al. 2017

Neuropsychopharmacol

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Recent work with noninvasive human brain imaging has started to investigate the effects of 3,4-methylenedioxymethamphetamine (MDMA) on large-scale patterns of brain activity. MDMA, a potent monoamine-releaser with particularly pronounced serotonin-releasing properties, has unique subjective effects that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic feelings. However, the neurobiological basis for these effects is not properly understood, and the present analysis sought to address this knowledge gap. To do this, we administered MDMA-HCl (100 mg p.o.) and, separately, placebo (ascorbic acid) in a randomized, doubleblind, repeated-measures design with twenty-five healthy volunteers undergoing fMRI scanning. We then employed a measure of global resting-state functional brain connectivity and follow-up seed-to-voxel analysis to the fMRI data we acquired. Results revealed decreased right insula/salience network functional connectivity under MDMA. Furthermore, these decreases in right insula/salience network connectivity correlated with baseline trait anxiety and acute experiences of altered bodily sensations under MDMA. The present findings highlight insular disintegration (ie, compromised salience network membership) as a neurobiological signature of the MDMA experience, and relate this brain effect to trait anxiety and acutely altered bodily sensations-both of which are known to be associated with insular functioning.

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“…Such findings suggest that adolescents with a high capacity for effective interpersonal relationships show more activity in regions important for complex visual processing and reduced activity in limbic regions often associated with self-referential thinking (Johnson et al, 2002), affective processing, and error detection (Bush, Luu, & Posner, 2000). Interestingly, scores on the adaptability scale showed no positive correlations with any brain region, whereas negative correlations were found in regions important for face processing, such as the fusiform gyrus and the insula, a region often associated with internal monitoring of emotional and visceral states (Binkofski et al, 1998;Dunckley et al, 2005;Vandenbergh et al, 2005), suggesting that increased activation of these regions may be associated with greater difficulty in adapting to new situations. The stress management scale, which measures the child's ability to cope with adversity and to regulate emotion and behavior, was associated with greater activity in the visual association cortex and reduced activity within regions important for monitoring bodily sensations, including the insula and primary somatosensory cortex.…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of emotional intelligence in adolescent children

Killgore

Yurgelun‐Todd

2007

Cognitive, Affective, & Behavioral Neuroscience

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The somatic marker hypothesis posits a key role for the ventromedial prefrontal cortex, amygdala, and insula in the ability to utilize emotions to guide decision making and behavior. However, the relationship between activity in these brain regions and emotional intelligence (EQ) during adolescence, a time of particular importance for emotional and social development, has not been studied. Using functional magnetic resonance imaging (f MRI), we correlated scores from the Bar-On Emotional Quotient Inventory, Youth Version (EQ-i:YV) with brain activity during perception of fearful faces in 16 healthy children and adolescents. Consistent with the neural efficiency hypothesis, higher EQ correlated negatively with activity in the somatic marker circuitry and other paralimbic regions. Positive correlations were observed between EQ and activity in the cerebellum and visual association cortex. The findings suggest that the construct of self-reported EQ in adolescents is inversely related to the efficiency of neural processing within the somatic marker circuitry during emotional provocation.

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Regional brain activation during proximal stomach distention in humans: A positron emission tomography study

Cited by 109 publications

References 59 publications

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation

Altered Insula Connectivity under MDMA

Neural correlates of emotional intelligence in adolescent children

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