Regional brain activity during transient self-induced anxiety and anger in healthy adults

Kimbrell, Tim A.; George, Mark S.; Parekh, Priti I.; Ketter, Terence A.; Podell, Daniel; Danielson, Aimee; Repella, Jennifer D.; Benson, Brenda E.; Willis, Mark W.; Herscovitch, Peter; Post, Robert M.

doi:10.1016/s0006-3223(99)00103-1

Cited by 230 publications

(152 citation statements)

References 58 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…Single-unit recording in human orbital frontal cortex showed increased firing rates to aversive stimuli including facial expressions of fear (32). Similar increases in orbital frontal activity were measured with functional imaging to angry expressions (33), to aversive stimuli (34), and to the actual induction of anger (35,36). Disruption of the medial prefrontal cortex by transcranial magnetic stimulation caused a delay in the recognition of angry faces but not happy faces (37).…”

Section: Discussionsupporting

confidence: 53%

Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

Best

Williams

Coccaro

2002

Proc. Natl. Acad. Sci. U.S.A.

276

155

View full text Add to dashboard Cite

Humans with lesions to the orbital͞medial prefrontal cortex and interconnected areas display impulsive aggressive behavior. To examine further the relationship between impulsive aggression and orbital͞medial prefrontal dysfunction, we measured the behavioral performance of psychiatric patients with a disorder characterized by impulsive aggression, Intermittent Explosive Disorder (IED). Presently, no evidence exists for a localized brain lesion in IED subjects. However, on the basis of the location of brain lesions that produce acquired impulsive aggression, we hypothesized that IED subjects would exhibit test performance similar to patients with lesions to the orbital͞medial prefrontal cortex. Subjects with IED and controls were administered three tests sensitive to lesions of the orbital͞medial prefrontal circuit: the Iowa Gambling Task, facial emotion recognition, and odor identification, and two control tests of working memory. On the gambling task, IED subjects continued to make disadvantageous decisions throughout the 100 trials, whereas controls learned to avoid disadvantageous decisions. On the facial recognition test, IED subjects were impaired at recognizing ''anger,'' ''disgust,'' and ''surprise,'' and they were biased to label neutral faces with ''disgust'' and ''fear.'' On odor identification, IED subjects were mildly anosmic and were impaired relative to controls. However, on the working memory control tests, both groups performed similarly. Across tests, the performance of IED subjects resembles the performance of patients with orbital͞medial prefrontal lesions in previous studies. These results extend the link between dysfunction of the orbital͞medial prefrontal circuit and impulsive aggressive behavior.

show abstract

Section: Discussionsupporting

confidence: 53%

Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

Best

Williams

Coccaro

2002

Proc. Natl. Acad. Sci. U.S.A.

276

155

View full text Add to dashboard Cite

show abstract

“…Though nicotine administration generally results in increased activity along prefrontal and paralimbic brain circuits, it is interesting that both increased and decreased ACC activation during cognitive task performance has been reported (see Section 2.2). ACC activity has been associated with anxiety and mood, with increased activity being associated with greater anxiety (Chua et al, 1999;Kimbrell et al, 1999) and decreased activity being associated with depressed mood (Drevets et al, 1997). This combination of findings suggests a potential interaction between expectation of the effects of smoking (e.g.…”

Section: Discussion: Functional Neuroanatomy Of Tobacco Use and Depenmentioning

confidence: 99%

“…Taken together, these studies of cigarette craving indicate that immediate responses to visual smoking-related cues (fMRI study) activate the brain reward system, limbic regions, and the visual processing system, while longer exposure to cues (FDG-PET study) leads to activation of the ACC, which mediates anxiety, alertness, and arousal (Chua et al, 1999;Critchley et al, 2001;Kimbrell et al, 1999;Naito et al, 2000;Rauch et al, 1999) and the OFC, which functions in part as a secondary processing center for sensory information (Rolls et al, 1998;Rolls and Baylis, 1994).…”

Section: Functional Brain Imaging Of Cigarette Cravingmentioning

confidence: 92%

Functional brain imaging of tobacco use and dependence

Brody

2006

Journal of Psychiatric Research

176

136

View full text Add to dashboard Cite

While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will achieve abstinence after 6 months or more of treatment. A greater understanding of the effects of smoking on brain function may (in conjunction with other lines of research) result in improved pharmacological (and behavioral) interventions. Many research groups have examined the effects of acute and chronic nicotine/cigarette exposure on brain activity using functional imaging; the purpose of this paper is to synthesize findings from such studies and present a coherent model of brain function in smokers. Responses to acute administration of nicotine/smoking include: a reduction in global brain activity; activation of the prefrontal cortex, thalamus, and visual system; activation of the thalamus and visual cortex during visual cognitive tasks; and increased dopamine (DA) concentration in the ventral striatum/nucleus accumbens. Responses to chronic nicotine/cigarette exposure include decreased monoamine oxidase (MAO) A and B activity in the basal ganglia and a reduction in α 4 β 2 nicotinic acetylcholine receptor (nAChR) availability in the thalamus and putamen. Taken together, these findings indicate that smoking enhances neurotransmission through cortico-basal ganglia-thalamic circuits either by direct stimulation of nAChRs, indirect stimulation via DA release or MAO inhibition, or a combination of these factors. Activation of this circuitry may be responsible for the effects of smoking seen in tobacco dependent subjects, such as improvements in attentional performance, mood, anxiety, and irritability.

show abstract

“…PET studies revealed neural correlates of different emotional states, such as grief, shame, guilt, and anger, using scripts specific for each emotion (Dougherty et al, 1999;George et al, 1995;Shin et al, 2000). For example, during the imagination of situations associated with anger, alterations of prefrontal blood flow with increased activity in ACC were found (Dougherty et al, 1999;Kimbrell et al, 1999). Using standardized negative emotional material from the International Affective Picture System (IAPS) Herpertz et al (2001) found increased activity in the amygdala of six patients with BPD without comorbid psychiatric disorders compared to controls.…”

Section: Functional Imaging Studies With Emotional Stressful and Sementioning

confidence: 99%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

171

View full text Add to dashboard Cite

Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology.

show abstract

Regional brain activity during transient self-induced anxiety and anger in healthy adults

Cited by 230 publications

References 58 publications

Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

Functional brain imaging of tobacco use and dependence

Neuroimaging in borderline personality disorder

Contact Info

Product

Resources

About