Regional cerebral blood flow difference between dementia with Lewy bodies and AD

Abstract

The authors studied 14 patients with dementia with Lewy bodies (DLB), 14 patients with AD, and 14 healthy control subjects with N-isopropyl-p-[123I]iodoamphetamine SPECT. Comparison with the statistical parametric mappings revealed that relative cerebral blood flow was lower in the occipital lobes and higher in the right medial temporal lobe in the DLB group than in the AD group. Decreased occipital perfusion and relatively well preserved medial temporal perfusion are features that distinguish DLB from AD.

A Case of Dementia with Atrophy of the Ambient Gyrus

“…Alzheimer's disease shows decreased blood flow in the posterior cingulate cortex and parietotemporal area (4). Dementia with Lewy bodies shows decreased occipital perfusion (5). The SPECT findings in the present case differed from those of Alzheimer's disease and dementia with Lewy bodies.…”

Differential Diagnosis of Dementia with Lewy Bodies and Alzheimer Disease Using Combined MR Imaging and Brain Perfusion Single-Photon Emission Tomography

“…This has been demonstrated by using SPECT and PET. [8][9][10] Recent studies have reported dopamine transporter loss in the striatal, caudate, and posterior putamen in patients with DLB. 11,12 Many studies investigating AD have found volume decreases in medial temporal structures and cerebral blood flow reductions in temporoparietal areas.…”

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

“…Studies comparing AD and DLB patients have pinpointed some differences in cognitive performance: memory impairment is less severe in DLB than AD (e.g., Calderon et al, 2001;Salmon et al, 1996;Shimomura et al, 1998), while visual-perceptual and spatial abilities are more impaired (e.g., Ala et al, 2001;Calderon et al, 2001;Gnanalingham et al, 1997;Salmon et al, 1996). Consistent with the neuropsychological profile, functional imaging studies show that patients with DLB more commonly have reduced perfusion in the occipital lobes than AD patients (Ishii et al, 1999;Lobotesis et al, 2001).…”