Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain

Inoue, Takeshi; Tsuchiya, Kiyoshi; Koyama, Tsukasa

doi:10.1016/0091-3057(94)90243-7

Cited by 238 publications

(121 citation statements)

References 33 publications

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“…With foot-shock stress, both the corticosterone concentration in serum and 5-HT concentration in the brain were increased; however, this tendency was partially reversed by the administration of s-limonene. It was also found that under serious foot shock conditions, the DA concentration in the hypothalamus would increase significantly (17).…”

Section: Discussionmentioning

confidence: 95%

Sub-Chronic Effects of s-Limonene on Brain Neurotransmitter Levels and Behavior of Rats

Zhou

Yoshioka

Yokogoshi

2009

J Nutr Sci Vitaminol

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SummaryThe present study was designed to gain insight into the effects of s -limonene on the brain after 1-wk administration. For this purpose, neurotransmitters such as dopamine (DA), serotonin (5-HT), ␥ -aminobutyric acid (GABA), glutamic acid (Glu) and some of their metabolites (DOPAC and 5-HIAA) were determined by HPLC-ECD and amino acid analyzer after 1-wk administration of s -limonene of different concentrations (0, 5, 25, 50 mg/ kg). Significant changes, such as GABA, 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT, were confirmed. At the same time, basal hypothalamic-pituitary-adrenal (HPA) activity after 1-wk administration of s -limonene was evaluated by corticosterone. Considering the increment of GABA and the changes of other neurotransmitters, anti-stress effects after 1-wk administration were observed. The experimental results showed that s -limonene could inhibit HPA activity under physical stress and this anti-stress effect of s -limonene may act through the GABA A receptor. Key Words s -limonene, anti-stress effects, GABA, 5-HT, foot shock s -Limonene is a component of lemon essential oil. It has been reported that acute administration of slimonene at high concentration can relieve physical and psychological stress ( 1 ). There are other reports about its acute functions in modifying monoamine levels in rat brains and brain waves from human tests ( 2 ). In addition, some researchers have also demonstrated by the microdialysis method that lemon essential oil components could stimulate the release of acetylcholine when rats were facing persistent painful stimulation ( 3 ). From these reports, we thought that s -limonene showed potential to be used as a medical additive or substitute therapy in the pharmaceutical field for helping people troubled by stress. However, it is unknown what happens in the brain after chronic or sub-chronic administration of s -limonene.In this study, the effects of 1-wk administration of slimonene on neurotransmitters were determined, and the possible anti-stress effects were evaluated. The possible relationship between neurotransmitter changes and anti-stress effects was also explored. MATERIALS AND METHODS Animals.Wistar male rats (200-250 g) (Japan SLC, Inc., Shizuoka, Japan) were individually housed at 23 Ϯ 1˚C in a room with a 12-h light-dark cycle. Rats were given a commercial diet (stock diet: CE-2, CLEA Japan, Inc., Tokyo, Japan). Foodstuff and water were freely available. Rats in each group were only used once with one purpose. The experimental procedures were in accordance with the guidelines of the University of Shizuoka for the Care and Use of Laboratory Animals, based on those of the American Association for Laboratory Animal Science.Dose-dependent changes of neurotransmitters induced by 1-wk administration of s-limonene. Seventy-two rats were split randomly into 4 groups (18 rats per group) , with similar body weights among the groups. The rats were orally administered corn oil (1 mL/kg, vehicle) or s -limonene dissolved in corn oil (5, 25, or 50 mg/kg) accord...

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Section: Discussionmentioning

confidence: 95%

Sub-Chronic Effects of s-Limonene on Brain Neurotransmitter Levels and Behavior of Rats

Zhou

Yoshioka

Yokogoshi

2009

J Nutr Sci Vitaminol

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“…Data from human and animal studies implicate the caudate in modulating anxiety responses to stress or threat (reviewed in Charney and Drevets, 2002). For example, studies in experimental animals suggested that dopamine release and turnover increased in the mesoaccumbens projections during mild-to-moderate stress, and in the nigrostriatal projections during more severe stress (Deutch and Roth, 1990;Inoue et al, 1994). In humans, one study suggested that during amphetamine challenge the magnitude of DA release in the ventral striatum correlated inversely with anxiety ratings in healthy humans (Drevets et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

Roiser

Lévy

Fromm

et al. 2007

Neuropsychopharmacol

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The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals.

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“…In this case, the relative PPI deficit could reflect an overactivity of the subcortical dopaminergic system, consistent with a sizeable literature on the effects of dopamine dysregulation on PPI Geyer et al, 2001). It has also been well established that central dopaminergic and serotoninergic pathways originating from the VTA and DRN are activated by a variety of physical and psychological stressors, including conditioned fear (Inoue et al, 1994;Beck and Fibiger, 1995;Yoshioka et al, 1995Yoshioka et al, , 1996Morrow et al, 1999). Furthermore, evidence shows that prior exposure to acute or chronic stressors can result in behavioral and pharmacological sensitization effects caused by changes dopaminergic (Pani et al, 2000;de Jong et al, 2005) and serotonergic tone (Adell et al, 1988;Chung et al, 2000;Matuszewich and Yamamoto, 2003).…”

Section: Discussionmentioning

confidence: 99%

Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion

Heldt

Ressler

2006

Brain Research

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The habenula complex modulates the a ctivity of dopamine and serotonin systems in the brain. An important question remains whether there is a link between habenula dysfunction and monoaminerelated disorders, such as schizophrenia. In this study, we describe an interaction between habenula lesions and stress that produces long-lasting effects on behavior. Mice received control lesions or bilateral electrolytic lesions of the habenula and were tested for fear-potentiated startle and freezing measures of conditioned fear. They w ere also tested for prepulse inhibition (PPI) and locomotor activity in the presence or absence of a dopaminergic agonist (apomorphine) or an atypical antipsychotic with mixed dopamine/serotonin antagonist properties (clozapine). There were no detectable effects of habenula lesions on fear conditioning and no effects on PPI in the absence o f stress. However, following conditioned fear stress, habenula-lesioned animals showed decreased PPI which normalized with clozapine. Lesioned animals also showed diminished activity at baseline, with hyperlocomotion following apomorphine. These data support the hypothesis that the habenula may be normally involved in stress-dependent regulation of monoamine systems.

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Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain

Cited by 238 publications

References 33 publications

Sub-Chronic Effects of s-Limonene on Brain Neurotransmitter Levels and Behavior of Rats

Sub-Chronic Effects of s-Limonene on Brain Neurotransmitter Levels and Behavior of Rats

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion

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