Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

Goldman‐Rakic, Patricia S.; Brown, Roger M.

doi:10.1016/0306-4522(81)90053-1

Cited by 341 publications

(136 citation statements)

References 35 publications

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“…Age-related loss in frontal lobe dopamine function has been repeatedly demonstrated in post-mortem as well as in vivo neuroimaging studies (eg Rinne, 109 de Keyser et al, 110 Suhara et al, 111 Kaasinen et al 112 and Volkow et al 113 ). This decline in dopamine function appears to begin early, 114 and has been estimated to occur at a rate of 11-13% per decade in age. 112 Thus, even though subjects from previous studies 52,59,[101][102][103]105,106,108 were still in their mid-adulthood, and were only 10-15 years older than our sample, these older subjects may already have considerably lower dopamine functional reserve than our younger subjects.…”

Section: Discussionmentioning

confidence: 99%

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

et al. 2005

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The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V 158 M COMT genotype was obtained on 159 schizophrenia patients and 84 healthy controls. The effects of COMT genotype on four measures of working memory/ executive functions (Wisconsin Card Sorting, digit span backward, Trail Making and N-back tests) and on MRI frontal brain volumes were examined. Genotype distributions were not significantly different between patients and controls. There were no significant genotype or genotype-by-group effects on any working memory/executive function measures. No genotype or genotype-by-diagnosis interaction effects were found with MRI frontal lobe volumes. Randomization analyses using [ 15 O]H 2 O positron emission tomography (PET) cerebral blood flow data found Val/Val patients had higher frontal lobe activation than Met/Met patients while performing the one-back task. Overall, these findings do not support a major role for COMT in increasing susceptibility for schizophrenia or in mediating frontal lobe function. Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition.

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Section: Discussionmentioning

confidence: 99%

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

et al. 2005

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“…Subsequently, Goldman-Rakic and Brown (1981) showed regional changes of monoamines in aging rhesus monkeys. Goldman-Rakic (1987) summarized the knowledge then available on the circuitry of the PFC and working memory mechanisms.…”

Section: Discussion the Role Of Da/glutamic Acid And Working Memorymentioning

confidence: 99%

Chronic NMDA Antagonism Impairs Working Memory, Decreases Extracellular Dopamine, and Increases D1 Receptor Binding in Prefrontal Cortex of Conscious Monkeys

Tsukada

Nishiyama

Fukumoto

et al. 2005

Neuropsychopharmacol

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“…Catecholamine biosynthesis, as measured by L-DOPA, is reduced by more than 60% in the PFC of aged rhesus monkeys (Goldman-Rakic and Brown 1981). Autoradiographic receptor binding studies have shown that in the superficial layers (I-III) of monkey area 46, α1-and α2-AR binding decreases with age, whereas densities of β-AR and norepinephrine transporter are unchanged (Bigham and Lidow 1995;Moore et al 2005).…”

Section: Norepinephrinementioning

confidence: 99%

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Hara

Rapp

Morrison

2011

AGE

121

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Rhesus monkeys provide a valuable model for studying the basis of cognitive aging because they are vulnerable to age-related decline in executive function and memory in a manner similar to humans. Some of the behavioral tasks sensitive to the effects of aging are the delayed response working memory test, recognition memory tests including the delayed nonmatching-to-sample and the delayed recognition span task, and tests of executive function including reversal learning and conceptual set-shifting task. Much effort has been directed toward discovering the neurobiological parameters that are coupled to individual differences in age-related cognitive decline. Area 46 of the dorsolateral prefrontal cortex (dlPFC) has been extensively studied for its critical role in executive function while the hippocampus and related cortical regions have been a major target of research for memory function. Some of the key age-related changes in area 46 include decreases in volume, microcolumn strength, synapse density, and α1-and α2-adrenergic receptor binding densities. All of these measures significantly correlate with cognitive scores. Interestingly, the critical synaptic subtypes associated with cognitive function appear to be different between the dlPFC and the hippocampus. For example, the dendritic spine subtype most critical to task acquisition and vulnerable to aging in area 46 is the thin spine, whereas in the dentate gyrus, the density of AGE (2012) large mushroom spines with perforated synapses correlates with memory performance. This review summarizes age-related changes in anatomical, neuronal, and synaptic parameters within brain areas implicated in cognition and whether these changes are associated with cognitive decline.

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Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

Cited by 341 publications

References 35 publications

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

Chronic NMDA Antagonism Impairs Working Memory, Decreases Extracellular Dopamine, and Increases D1 Receptor Binding in Prefrontal Cortex of Conscious Monkeys

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

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