Regional Chemotherapy and Local Cryotherapy for Cancer

Benson, Jerrel W.

doi:10.1159/000224664

Cited by 13 publications

(3 citation statements)

References 14 publications

(18 reference statements)

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“…The key to effective drug delivery is in the thought that if drugs are administered during cryosurgery, the therapeutic agents will become sequestered or trapped in the tumor as microcirculatory failure develops. This timing of drug administration is supported by the experiments of Benson who, producing a cryolesion in the dog's tongue, noted that infused methylene blue solution became trapped in the previously frozen volume as the circulation failed in the thawing period [14]. He then extended this principle to the use of methotrexate as an adjunct to cryosurgery of oral cancer.…”

Section: Adjunctive Therapymentioning

confidence: 98%

Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: Adjunctive Therapymentioning

confidence: 98%

Experimental cryosurgery investigations in vivo

2009

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“…A combination effect in terms of improved survival in the animal model was seen for various substances, e. g. for cyclophosphamide and 5-fluorouracil [90,92]. With synchronized administration in contrast to preinterventional administration, trapping of the substance in the cryolesion could be shown for peplomycin and bleomycin [93,94]. Combination therapy similar to electrochemotherapy also seems possible since local cryoablation in melanoma cells results in an increase in the permeability of cell walls for bleomycin [95].…”

Section: Combination Therapymentioning

confidence: 99%

Current Technique and Application of Percutaneous Cryotherapy

Mahnken

König

Figiel

2018

Fortschr Röntgenstr

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ABSTR AC TPurpose Local ablative therapies have become an established treatment option in interventional oncology. Radiofrequency ablation (RFA) and microwave ablation (MWA) are a standard of care in the treatment of hepatocellular carcinoma (HCC). Currently, there is an increasing interest in cryotherapy, one of the oldest ablation techniques. It has some unique characteristics with regard to technology and mechanism of action.Materials and Methods A systematic literature search using the terms cryotherapy, cryosurgery and cryoablation was performed. Selected studies are presented dealing with the mechanism of action, cryobiology and clinical use of percutaneous, image-guided cryoablation. Recent developments and perspectives are presented.Results Cryotherapy is increasingly used and has been included in guidelines for selected tumor entities such as renal cell carcinoma. Cryo-immunotherapy and combination treatments are future areas of interest.Conclusion Cryoabalation may be used in many indications.Its major advantages are its unique visualization and the anesthesiologic effects of cold. While there are only a few prospectively randomized trials, the existing data on the use of cryoablation is promising. Its use appears to be justified in selected tumors, oligometastatic patients and for palliative indications.

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“…The thought that cancer chemotherapeutic drugs can be concentrated in the tumor area by appropriately timed delivery, first suggested by Benson,53 is an interesting and relatively unexplored possibility. The rationale is based on the failure of the microcirculation during thawing.…”

Section: Selective Cryotherapymentioning

confidence: 99%

Selective Cryotherapy

Gage¹

2004

Cell Preservation Technology

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Freezing tissue in situ produces a response that ranges from inflammatory to destructive. The nature of the response is related to the severity of the cryogenic injury, which is dependent upon the tissue temperature, the duration of freezing, and other factors in the freeze-thaw cycle. Therefore, by adjusting the freeze-thaw cycle to an appropriate program, the tissue response may be manipulated to achieve a selected goal. Selective cryotherapy depends on differences in the sensitivity of cells to cold injury. Most normal cells die at rather elevated freezing temperatures, but the fibrocollagenous matrix is preserved, which yields a favorable healing of the wound. Cancer cells are resistant to freezing injury and require low freezing temperatures and repeated freeze-thaw cycles. These differences permit exploration of the expanded uses of cryoablative techniques. This review focuses on the two faces of cryotherapy, that is, its destructive and preservative aspects. The efficacy of cryosurgery for tumors may be increased by adjunctive therapy, which will influence the fate of cells in an apoptotic state in the frozen volume. Tissue warming techniques can prevent destruction in unwanted areas. The current and potential use of warmer freezing temperatures features selective destruction of some cells, while avoiding injury to others, and selective functional compromise of cells with later return of function. Elevated freezing temperatures may also be used to elicit a non-destructive response to induce changes in the process of healing. These tissue responses and adjunctive therapy provide the direction for future research and therapy.

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Regional Chemotherapy and Local Cryotherapy for Cancer

Cited by 13 publications

References 14 publications

Experimental cryosurgery investigations in vivo

Experimental cryosurgery investigations in vivo

Current Technique and Application of Percutaneous Cryotherapy

Selective Cryotherapy

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