Detecting and attributing vegetation variations in the Yellow River Basin (YRB) is vital for adjusting ecological restoration strategies to address the possible threats posed by changing environments. On the basis of the kernel normalized difference vegetation index (kNDVI) and key climate drivers (precipitation (PRE), temperature (TEM), solar radiation (SR), and potential evapotranspiration (PET)) in the basin during the period from 1982 to 2022, we utilized the multivariate statistical approach to analyze the spatiotemporal patterns of vegetation dynamics, identified the key climate variables, and discerned the respective impacts of climate change (CC) and human activities (HA) on these variations. Our analysis revealed a widespread greening trend across 93.1% of the YRB, with 83.2% exhibiting significant increases in kNDVI (p < 0.05). Conversely, 6.9% of vegetated areas displayed a browning trend, particularly concentrated in the alpine and urban areas. With the Hurst index of kNDVI exceeding 0.5 in 97.5% of vegetated areas, the YRB tends to be extensively greened in the future. Climate variability emerges as a pivotal determinant shaping diverse spatial and temporal vegetation patterns, with PRE exerting dominance in 41.9% of vegetated areas, followed by TEM (35.4%), SR (13%), and PET (9.7%). Spatially, increased PRE significantly enhanced vegetation growth in arid zones, while TEM and SR controlled vegetation variations in alpine areas and non-water-limited areas such as irrigation zones. Vegetation dynamics in the YRB were driven by a combination of CC and HA, with relative contributions of 55.8% and 44.2%, respectively, suggesting that long-term CC is the dominant force. Specifically, climate change contributed to the vegetation greening seen in the alpine region and southeastern part of the basin, and human-induced factors benefited vegetation growth on the Loess Plateau (LP) while inhibiting growth in urban and alpine pastoral areas. These findings provide critical insights that inform the formulation and adaptation of ecological conservation strategies in the basin, thereby enhancing resilience to changing environmental conditions.