Regional dependency of the vascular smooth muscle cell contribution to the mechanical properties of the pig ascending aortic tissue

Tremblay, Dominique; Cartier, Raymond; Mongrain, Rosaire; Leask, Richard L.

doi:10.1016/j.jbiomech.2010.04.018

Cited by 24 publications

(21 citation statements)

References 13 publications

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“…Sugita and Matsumoto (2013a) found more collagen in the distal and dorsal aortic regions than in the proximal and ventral regions. Tremblay et al (2010) reported heterogeneous orientation, density and contractile properties of aortic VSMCs within the ascending porcine aorta. Further segmental differences of the smooth muscle orientation along the entire porcine aorta have recently been reported (Tonar et al, 2015).…”

Section: Age-related and Segmental Differences In The Porcine Aortamentioning

confidence: 98%

Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta

Tonar

Kubíková

Prior

et al. 2015

Annals of Anatomy - Anatomischer Anzeiger

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Section: Age-related and Segmental Differences In The Porcine Aortamentioning

confidence: 98%

Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta

Tonar

Kubíková

Prior

et al. 2015

Annals of Anatomy - Anatomischer Anzeiger

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“…In the tunica media of the abdominal aorta of healthy pigs, the volume fraction of α-smooth muscle actin-positive cells ranges from 50 to 60 % . The orientation, density, and contractile properties of aortic VSMC have been found (Ruckman et al 1994) and recently confirmed (Tremblay et al 2010) to be heterogeneous within the ascending porcine aorta. Both the phenotypic variability (synthetic vs. contractile phenotype) and the arrangement of VSMC have been hypothesized to underlie the non-uniform remodeling and weakening of the aorta during aneurysms (Tremblay et al 2010).…”

Section: Differences Between Aortic Segmentsmentioning

confidence: 79%

“…The orientation, density, and contractile properties of aortic VSMC have been found (Ruckman et al 1994) and recently confirmed (Tremblay et al 2010) to be heterogeneous within the ascending porcine aorta. Both the phenotypic variability (synthetic vs. contractile phenotype) and the arrangement of VSMC have been hypothesized to underlie the non-uniform remodeling and weakening of the aorta during aneurysms (Tremblay et al 2010). In the human aorta, regional variations in VSMC and intercellular substances have recently been reported in research on aortic aneurysms (Wilson et al 2012;Schriefl et al 2012a).…”

Section: Differences Between Aortic Segmentsmentioning

confidence: 79%

Segmental differences in the orientation of smooth muscle cells in the tunica media of porcine aortae

Tonar

Kochová

Cimrman

et al. 2014

Biomech Model Mechanobiol

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The orientation of vascular smooth muscle cells of porcine aortae was assessed to test the widely accepted assumption that these smooth muscle cells are arranged in two helices. We used tangential histological sections of 82 samples of five anatomical segments of thoracic and abdominal porcine aortae and three age groups in animals ranging in age from 5 to 210 days. The distribution of the orientation of smooth muscle cell nuclei in five proximodistal segments of the porcine aortae was determined using an algorithm that fitted a mixture of one to five von Mises probability distributions of the data retrieved from histological micrographs. Automated tracking of the nuclei was confirmed by and consistent with manual histological analysis. The orientation of the vascular smooth muscle cells was successfully fitted using two von Mises distributions in most of the samples with different ages, wall thicknesses, and anatomical positions, which corresponds to two populations of vascular smooth muscle cells. A minor fraction of samples also required a tertiary von Mises distribution to describe the orientation of the smooth muscle cell nuclei. The distribution of vascular smooth muscle cells in five aortic segments ranging from the thoracic ascending aorta to the abdominal intrarenal aorta exhibited similar main directions but different shapes. These results are consistent with the widely used model of two muscular helices intermingling in the arterial wall. Furthermore, we calculated the central angles of symmetry and the mean value of angles between the two assumed smooth muscle directions. We also successfully approximated the orientation of the smooth muscle cells using a mixture of von Mises distributions and our open-source software named dist_mixtures. This method is openly available to researchers who are interested in mathematically assessing the orientation of cell nuclei in various tissues.

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“…geometry and mechanical properties). Defining the geometry and mechanics of healthy and diseased tissue is a constant endeavour in biomedical engineering (Choudhury et al, 2009;Tremblay et al, 2010). If the proper information is available, then CFD simulations are feasible, however experimental validation is still crucial.…”

Section: Computational Fluid Dynamics and Photochromic Molecular Flowmentioning

confidence: 99%

In Vitro Leukocyte Adhesion in Endothelial Tissue Culture Models Under Flow

Cooper¹,

Dick²,

Emmott³

et al. 2012

Biomedical Science, Engineering and Technology

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Regional dependency of the vascular smooth muscle cell contribution to the mechanical properties of the pig ascending aortic tissue

Cited by 24 publications

References 13 publications

Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta

Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta

Segmental differences in the orientation of smooth muscle cells in the tunica media of porcine aortae

In Vitro Leukocyte Adhesion in Endothelial Tissue Culture Models Under Flow

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