Regional differences in GABAergic modulation for TEA-induced synaptic plasticity in rat hippocampal CA1, CA3 and dentate gyrus

Suzuki, Etsuko; Okada, Takashi

doi:10.1016/j.neures.2007.06.1472

Cited by 14 publications

(9 citation statements)

References 37 publications

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“…This is not an unlikely scenario. It has already been demonstrated that there are multiple forms of plasticity made between mossy fibres and inhibitory interneurons, which comprise the major targets numerically333435. The properties that we observe for mossy fibre LTP, notably a role for Ca 2+ -induced Ca 2+ release26 and GluK1-containing KARs12192223, is paralleled by properties of synaptic facilitation that we observed at these same synapses1426.…”

Section: Discussionsupporting

confidence: 80%

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP

Nisticò

Dargan

Amici

et al. 2011

Sci Rep

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It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu1 and mGlu5 receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the pharmacological activation of either mGlu1 or mGlu5 receptors, provided that kainate receptors are also stimulated. Like conventional mossy fibre LTP, chemically-induced mossy fibre LTP (chem-LTPm) depends on Ca2+ release from intracellular stores and the activation of PKA. Similar synergistic interactions between mGlu receptors and kainate receptors were observed at the level of Ca2+ signalling in individual giant mossy fibre boutons. Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain.

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Section: Discussionsupporting

confidence: 80%

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP

Nisticò

Dargan

Amici

et al. 2011

Sci Rep

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“…2b). The finding that bilobalide had inhibitory effects on the GABAergic system was expected because it was reported that GABAergic modulation of tetraethylammonium-induced synaptic plasticity was increased in DG compared with that observed in CA1 synapses [15]. The similarity between the effects of PTX and bilobalide on MPP-DG synaptic plasticity (Fig.…”

Section: Discussionmentioning

confidence: 66%

“…The details of the procedures have been described elsewhere [15]. In short, the rats were deeply anesthetized using pentobarbital sodium, and their brains were removed quickly.…”

Section: Preparationsmentioning

confidence: 99%

The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields

et al. 2011

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Bilobalide, a unique constituent of Ginkgo biloba, has been reported to potentiate population spikes in hippocampal CA1 pyramidal cells and to protect the brain against cell death. In this study, the effects of bilobalide on synaptic transmission and its plasticity in rat hippocampal subfields were electrophysiologically investigated. Bilobalide (50 μM) significantly potentiated the input-output relationship at Schaffer collateral (SC)-CA1 synapses but not at medial perforant path (MPP)-dentate gyrus (DG), lateral perforant path (LPP)-DG, or mossy fiber (MF)-CA3 synapses. Facilitative effects of bilobalide on synaptic plasticity were only observed at MPP-DG synapses, in which the induction of long-term depression was blocked in the presence of bilobalide. However, no effect on synaptic plasticity was observed at SC-CA1 synapses. These results suggest that bilobalide has differential effects on synaptic efficacy in each hippocampal subfield.

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“…Hippocampal slices (400 μm thick) were obtained from 3‐week‐old male Wistar rats. The details of the procedures have been described elsewhere (Suzuki & Okada, 2007). In short, the rats were deeply anesthetized with pentobarbital sodium, and their brains were then removed.…”

Section: Methodsmentioning

confidence: 99%

Stratum oriens stimulation‐evoked modulation of hippocampal long‐term potentiation involves the activation of muscarinic acetylcholine receptors and the inhibition of Kv7/M potassium ion channels

Suzuki

Okada

2012

Eur J of Neuroscience

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Acetylcholine is considered to be an endogenous modulator of hippocampal neurotransmission and synaptic plasticity. The activation of muscarinic acetylcholine receptors (mAChRs) reportedly enhances hippocampal synaptic plasticity, which plays an important role in memory function; however, the mechanism by which it enhances synaptic plasticity remains unclear. Here, we examined the involvement of the inhibition of Kv7/M K(+) channels, which are targets of mAChR modulation, during mAChR activation-induced enhancement of long-term potentiation (LTP) at rat hippocampal Schaffer collateral (SC)-CA1 synapses. When an electrical stimulus was applied to the stratum oriens before tetanic stimulation of the SCs, the magnitude of the induced SC-CA1 synapse LTP was enhanced as compared with that induced without stratum oriens stimulation. In the presence of the mAChR antagonist atropine, tetanic stimulation induced stable LTP, but the stratum oriens stimulation-evoked enhancement of LTP was abolished. The additional application of XE991, a selective blocker of Kv7/M K(+) channels, rescued the atropine-induced inhibition of LTP enhancement. The phospholipase C (PLC) inhibitor U-73122 inhibited the stratum oriens stimulation-evoked enhancement of LTP. Application of the T/R-type voltage-dependent Ca(2+) channel (VDCC) blocker Ni(2+) abolished the stratum oriens stimulation-evoked enhancement of LTP. In addition, tetanic stimulation with preceding stratum oriens stimulation was able to induce LTP during N-methyl-d-aspartate receptor blockade. We therefore propose that stratum oriens stimulation inhibits Kv7/M K(+) channels through mAChR activation-induced PLC activation, which leads to VDCC activation, and hence causes sufficient Ca(2+) influx to enhance LTP.

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Regional differences in GABAergic modulation for TEA-induced synaptic plasticity in rat hippocampal CA1, CA3 and dentate gyrus

Cited by 14 publications

References 37 publications

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP

The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields

Stratum oriens stimulation‐evoked modulation of hippocampal long‐term potentiation involves the activation of muscarinic acetylcholine receptors and the inhibition of Kv7/M potassium ion channels

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