Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs

Takeuchi, Hina; Suzuki, Masayoshi; Goto, Ryohei; Tezuka, Kenta; Fuchs, Holger; Ishiguro, Naoki; Terasaki, Toshio; Braun, Clemens; Uchida, Yasuo

doi:10.1007/s11095-022-03275-1

Cited by 5 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, recent studies have indicated that the arachnoid membrane highly expresses many solute transporters regulating CSF composition. For example, Takeuchi et al [ 83 ] have used quantitative targeted absolute proteomics to compare the expression of a variety of transporters at the blood-arachnoid barrier and the blood-spinal cord barrier. Some organic anionic and cationic drug transporters were only expressed in the former.…”

Section: Elements Of the Blood-csf Barrier And The Csf And Glymphatic...mentioning

confidence: 99%

A year in review: brain barriers and brain fluids research in 2022

Keep

Jones

Hamilton

et al. 2023

Fluids Barriers CNS

View full text Add to dashboard Cite

This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

show abstract

Section: Elements Of the Blood-csf Barrier And The Csf And Glymphatic...mentioning

confidence: 99%

A year in review: brain barriers and brain fluids research in 2022

Keep

Jones

Hamilton

et al. 2023

Fluids Barriers CNS

View full text Add to dashboard Cite

show abstract

“…Monocarboxylic transporters (MCTs) play a signi cant role in the lactate shuttle, which may promote intracellular and intercellular lactate shuttle in the central nervous system (22). There is research indicating that ECs predominantly express Monocarboxylic transporter1 (MCT1) in the spinal cord (23), indicating ECs may regulate axon regeneration by transporting lactate via MCT1. However, the lack of evidence regarding how MCT1 is expressed in ECs after SCI and its functional implications in this context requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

MCT1-Mediated Endothelial Cell Lactate Shuttle as a Target for Promoting Axon Regeneration after Spinal Cord Injury

Shi,

Xu,

Ding

et al. 2024

Preprint

View full text Add to dashboard Cite

Vascular damage following spinal cord injury (SCI) precipitates ischemia and hypoxia at the injury site, leading to profound metabolic disturbances. The implications of these metabolic disorders on neural tissue remodeling and functional recovery remain poorly understood. Our study elucidates the consequences of the hypoxic environment induced by SCI, which significantly enhances glycolysis and lactate production at the injury's epicenter. And our findings revealed a marked decrease in the expression of Monocarboxylate Transporter 1 (MCT1), a crucial transporter facilitating lactate delivery to neurons and consequently supporting their energy metabolism, within vascular endothelial cells emerging after SCI. This decrease disrupts lactate transport to neurons, resulting in metabolic imbalances that impede axonal regeneration. Remarkably, our research demonstrates that targeted delivery of adeno-associated virus (AAV) injections to restore MCT1 expression in endothelial cells (ECs) promotes axonal regeneration and functional recovery in SCI mouse models. These findings reveal a previously unrecognized connection between lactate shuttling from ECs to neurons after SCI and neural functional recovery. Highlighting a novel metabolic pathway for intervention, our study opens new therapeutic avenues for the treatment of spinal cord injuries, suggesting that targeting lactate transport mechanisms may offer significant benefits in SCI recovery.

show abstract

Proton-Coupled Oligopeptide Transport (Slc15) in the Brain: Past and Future Research

Xiang

Keep

2023

Pharm Res

View full text Add to dashboard Cite

Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs

Cited by 5 publications

References 41 publications

A year in review: brain barriers and brain fluids research in 2022

A year in review: brain barriers and brain fluids research in 2022

MCT1-Mediated Endothelial Cell Lactate Shuttle as a Target for Promoting Axon Regeneration after Spinal Cord Injury

Proton-Coupled Oligopeptide Transport (Slc15) in the Brain: Past and Future Research

Contact Info

Product

Resources

About