This work is based on a drainage basin-scale geomorphological investigation combined with flood modeling. It is focused on the assessment of flood critical areas for the implementation of a geomorphology-based urban Early Warning System (EWS) in the urban area of Lanciano and the Feltrino Stream basin (a minor coastal basin of the Abruzzo hills, Central Italy). This area was investigated by combining: pre-existing geological, geomorphological, and hazard data and new detailed field surveys and mapping of geomorphological and hydrographical features (superficial and buried natural and urban stream network). The study was integrated with 2D flood numerical modeling for verifying the expected flooded areas and calibrating the critical areas. All the collected data were integrated into a geodatabase, and an expert-based approach through a geomorphology-based matrix allowed us to define the main categories of flood critical areas. The assessment of the critical areas supported the emplacement of a network of rainfall, temperature, and flood gauges. The geodatabase, the derived critical areas, and the gauge network contributed to set up an urban EWS, integrated with the regional forecast-based warning system. This system provides combined forecast-based, rainfall threshold-based, and flood monitoring-based alerts for floods. It incorporates communication tools for civil protection management. Finally, the EWS provides a tool for civil protection purposes and for the management of flood critical areas and the mitigation of the related risks by local authorities and will be integrated with sensors related to other hazards (i.e., landslides, wind, etc.).