Regional epidemiology of invasive pneumococcal disease in Asian adults: epidemiology, disease burden, serotype distribution, and antimicrobial resistance patterns and prevention

Hung, Ivan Fan-Ngai; Tantawichien, Terapong; Tsai, Ying Huang; Patil, Shilpa; Zotomayor, Ricardo

doi:10.1016/j.ijid.2013.01.004

Cited by 50 publications

(40 citation statements)

References 116 publications

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“…Pneumococcal vaccine is not widely available throughout the world especially in Asia [34] and Latin America countries [35]. The lack of data on adult pneumococcal disease and the doubts regarding the effectiveness of vaccination, particularly in immunocompromised patients, may be factors in the limited use of the pneumococcal vaccination [36].…”

Section: Discussionmentioning

confidence: 99%

Low rate of influenza and pneumococcal vaccine coverage in rheumatoid arthritis: Data from the international COMORA cohort

Hmamouchi

Winthrop

Launay

et al. 2015

Vaccine

112

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Section: Discussionmentioning

confidence: 99%

Low rate of influenza and pneumococcal vaccine coverage in rheumatoid arthritis: Data from the international COMORA cohort

Hmamouchi

Winthrop

Launay

et al. 2015

Vaccine

112

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“…Much higher rates are reported from Asian countries. 48,49 Penicillin resistant pneumococci are more likely to show higher resistance to other classes of antimicrobials. Current figures of resistance in US include 35% to macrolides, 10% to clindamycin, 30% to trimethoprim sulfamehoxazole, 18% to doxycycline and 2% to respiratory quinolones.…”

Section: Gram-positive Bacteriamentioning

confidence: 99%

“…These programmes are desparetely needed and may be lacking even in hospitals in the developed part of the world. 124,125 Conclusions Antimicrobial resistance, particularly MDR phenotype in clinically important community and nosocomial Table 1 Frequent resistance mechanisms for selected antibacterial antibiotics in clinically important gram-negative bacteria (47,48,50,55,58,59,61,63,70,76,84,91) Arm-A meythylase confers high-level resistance. rRNA methylases are also described.…”

Section: Acinetobacter Baumanniimentioning

confidence: 99%

Epidemiology of antimicrobial resistance in bloodstream infections

2016

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Antimicrobial resistance in bacterial pathogens is a worldwide challenge leading high morbidity and mortality in clinical settings. Multidrug resistant patterns in gram-positive and -negative bacteria have resulted in difficult-to-treat or even untreatable infections with conventional antimicrobials. Since the early identification of causative microorganisms and their antimicrobial susceptibility patterns in patients with bacteremia and other serious infections is lacking in many healthcare institutions, broad spectrum antibiotics are liberally and mostly unnecessarily used. Such practice has, in turn, caused dramatic increases in emerging resistance and when coupled with poor practice of infection control, resistant bacteria can easily be disseminated to the other patients and the environment. Thus, availability of updated epidemiological data on antimicrobial resistance in frequently encountered bacterial pathogens will be useful not only for deciding on empirical treatment strategies, but also devising an effective antimicrobial stewardship program in hospitals.

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“…treptococcus pneumoniae serogroup 19 clonal complex 320/271 (CC320/271) includes important multidrug-resistant (MDR) clones, including sequence type 271(ST271), responsible for both invasive pneumococcal disease (IPD) and noninvasive pneumococcal disease in most Asian countries (1,2) and in parts of China (3). In the United States and other western countries, serotype 19A-ST320, a multidrug-resistant (MDR) clone, has been highly successful after the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) (4).…”

mentioning

confidence: 99%

Genetic Analyses of Penicillin Binding Protein Determinants in Multidrug-Resistant Streptococcus pneumoniae Serogroup 19 CC320/271 Clone with High-Level Resistance to Third-Generation Cephalosporins

Ang

Liyanapathirana

et al. 2015

Antimicrob Agents Chemother

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Streptococcus pneumoniae serogroup 19 clonal complex 320/271 (CC320/271) includes important multidrug-resistant (MDR) clones, including sequence type 271(ST271), responsible for both invasive pneumococcal disease (IPD) and noninvasive pneumococcal disease in most Asian countries (1, 2) and in parts of China (3). In the United States and other western countries, serotype 19A-ST320, a multidrug-resistant (MDR) clone, has been highly successful after the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) (4). ST320 is a double-locus variant (DLV) of the originally described Taiwan 19F -14 (Pneumococcal Molecular Epidemiology Network; PMEN14) clone, ST236, from isolates from a Taiwanese hospital in 1997 (5) and has undergone a capsular switch to nonvaccine serotype 19A, likely through recombination that altered the wzy polymerase gene. In mainland China, 43.8% of cases of IPD were reportedly due to serogroup 19 during 2005 to 2011, with 84.7% of isolates belonging to CC320/ 271, including ST271, ST320, and ST236 (3). In Hong Kong, we reported the introduction of the Taiwan 19F -14 (ST236) clone back in 1999 (6), prior to the introduction of PCV7. These strains were resistant to ␤-lactams, tetracyclines, and macrolides but susceptible to chloramphenicol and replaced the predominant MDR Spain 23F -1 and Spain 6B -2 clones in the late 1990s (7). The Hong Kong Special Administrative Region (HKSAR) introduced PCV7 to the childhood immunization program in October 2009 and subsequently introduced the 10-valent vaccine in October 2010 and PCV13 in 2011 in keeping with the changes in the vaccine coverage of prevalent serotypes. Of the serotypes included in PCV7, serotype 19F is the least likely to evoke a protective immune response according to both vaccine efficacy trials and in vivo studies (8, 9). Therefore, despite the initial decrease in carriage and invasive disease due to serotype 19F, reemergence of the disease might be anticipated due to a weaning of antibody responses over time. This is reflected by recent studies in Hong Kong comparing pre-and postvaccination serotype carriage, where a significant difference was not found for serotype 19F (10). In addition, during this period, an increasing level of resistance of S. pneumoniae to the third-generation cephalosporin cefotaxime was observed. Given the ability of pneumococci to adapt and transform, we sought to examine the levels of antimicrobial and ␤-lactam resistance of these isolates and study the polymorphisms of amino acid sequences of penicillin binding protein 1a (PBP1a), PBP2b, and PBP2x that might be related to different levels of

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Regional epidemiology of invasive pneumococcal disease in Asian adults: epidemiology, disease burden, serotype distribution, and antimicrobial resistance patterns and prevention

Cited by 50 publications

References 116 publications

Low rate of influenza and pneumococcal vaccine coverage in rheumatoid arthritis: Data from the international COMORA cohort

Low rate of influenza and pneumococcal vaccine coverage in rheumatoid arthritis: Data from the international COMORA cohort

Epidemiology of antimicrobial resistance in bloodstream infections

Genetic Analyses of Penicillin Binding Protein Determinants in Multidrug-Resistant Streptococcus pneumoniae Serogroup 19 CC320/271 Clone with High-Level Resistance to Third-Generation Cephalosporins

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