Regional Esophageal Dysfunction in Scleroderma and Achalasia using Multichannel Intraluminal Impedance and Manometry

Mainie, Inder; Tutuian, Radu; Patel, Alpesh; Castell, Donald O.

doi:10.1007/s10620-007-9845-x

Cited by 29 publications

(23 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17 Indeed, Mainie et al showed that patients with scleroderma had more frequently incomplete bolus clearance in the upper part of the esophagus compared to controls despite similar amplitude of proximal waves. 18 Moreover, Villadsen observed a lower distensibility of the proximal esophagus in patients with SSc compared to controls. 19 Finally, a neural dysregulation could also induce changes in proximal esophageal contraction.…”

Section: Discussionmentioning

confidence: 97%

Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study

Roman

Hot

Fabien

et al. 2010

Diseases of the Esophagus

View full text Add to dashboard Cite

Esophageal involvement occurs in about 80% of patients with systemic sclerosis, with a marked diminution of peristaltic pressures in the distal two-thirds of the esophagus. Our aims were to more fully characterize esophageal motility disorders in systemic sclerosis using high-resolution manometry (HRM) and to determine predictive factors of esophageal involvement. Fifty-one patients (46 females) with systemic sclerosis were included in this retrospective study. Esophageal motility was characterized with HRM. The demographic data, esophageal symptoms, presence of other organ involvement, and autoantibody profile (anti-Scl70 antibodies [Scl70], anticentromere antibodies [ACA]) were recorded for all patients. Esophageal body dysmotility was present in 33 patients (67.3%) and was associated with hypotensive esophagogastric junction in 27 patients (55.1%). The velocity of proximal contractions was higher in patients with esophageal body dysmotility compared to patients with normal peristalsis (median 10.8 cm/s vs. 5.5, P = 0.04). The amplitude of middle esophageal contraction but not of distal esophageal contraction was reduced in patients with hypoperistalsis. Diffuse esophageal skin involvement, presence of Scl70 and absence of ACA were associated with esophageal involvement. Esophageal symptoms encountered in 87.5% of patients were not predictive of esophageal dysmotility. This HRM series confirms the high prevalence of esophageal body dysmotility in systemic sclerosis. Diffuse skin involvement, positive Scl70 and negative ACA, but not esophageal symptoms, may predict esophageal body dysmotility.

show abstract

Section: Discussionmentioning

confidence: 97%

Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study

Roman

Hot

Fabien

et al. 2010

Diseases of the Esophagus

View full text Add to dashboard Cite

show abstract

“…These patients already have fluid stasis and therefore a low impedance baseline. We studied 20 patients with achalasia and 15 with scleroderma using MII-OM, and while the overall bolus transit was impaired in both groups, patients with scleroderma showed normal regional pressure and bolus transit in the proximal oesophagus 10 11…”

Section: Multichannel Intraluminal Impedancementioning

confidence: 99%

“…Patients may experience persistent postoperative dysphagia following surgery 11. Using technetium-99m jello to assess bolus transit, Hunt et al studied 26 patients preoperatively and were able to detect a subtle functional motility disorder that predisposed to postoperative dysphagia and hence predict surgical outcome 13.…”

Section: Multichannel Intraluminal Impedancementioning

confidence: 99%

High resolution manometry and multichannel intraluminal impedance oesophageal manometry in clinical practice

Mainie¹

2010

Frontline Gastroenterol

View full text Add to dashboard Cite

REVIEWThe past decade has seen new technological advances in the investigation of oesophageal motility disorders. Multichannel intraluminal impedance monitoring has been used as an adjunct to conventional manometry in the assessment of oesophageal function, independent of radiography. High resolution manometry provides additional information over conventional manometry, and its topographic analysis makes interpretation of studies easier. Both utilities in non-obstructive dysphagia have been used ultimately in research; however, more studies are addressing their clinical application.

show abstract

“…The authors concluded that in achalasia patients, low-baseline impedance levels and air entrapment in the proximal oesophagus limit the value of intraluminal impedance monitoring as a test of oesophageal emptying. Mainie et al 25 evaluated bolus presence and segmental transit in 20 achalasia patients and 15 patients with scleroderma using combined impedance-manometry. While the overall bolus transit was impaired in both groups, scleroderma patients showed normal regional pressure and bolus transit in the proximal oesophagus.…”

Section: Clinical Studiesmentioning

confidence: 99%

Review article: intra‐oesophageal impedance monitoring for the assessment of bolus transit and gastro‐oesophageal reflux

Conchillo

Smout

2008

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

Regional Esophageal Dysfunction in Scleroderma and Achalasia using Multichannel Intraluminal Impedance and Manometry

Abstract: While the overall bolus transit is impaired in both patients with achalasia and scleroderma regional pressure and bolus transit differences exist. Bolus transit abnormalities result from abnormal esophageal body contraction and not abnormal LES relaxation.

Cited by 29 publications

References 17 publications

Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study

Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study

High resolution manometry and multichannel intraluminal impedance oesophageal manometry in clinical practice

Review article: intra‐oesophageal impedance monitoring for the assessment of bolus transit and gastro‐oesophageal reflux

Contact Info

Product

Resources

About