Regional Flow Responses to Exercise

Carù, B; Colombo, Emilio; Santoro, Francesco; Laporta, A.; Maslowsky, F.

doi:10.1378/chest.101.5_supplement.223s

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…With exercise, a greater fraction of CO is delivered to the activated skeletal muscle (3,16,47). In the present study, we estimated CO and muscle perfusion from a same set of postexercise MRI data to assess whether with exercise hyperemia in Table 4.…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Zhang

Layec

Hanrahan

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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Peripheral artery disease (PAD) in the lower extremities often leads to intermittent claudication. In the present study, we proposed a low-dose DCE MRI protocol for quantifying calf muscle perfusion stimulated with plantar flexion and multiple new metrics for interpreting perfusion maps, including the ratio of gastrocnemius over soleus perfusion (G/S; for assessing the vascular redistribution between the two muscles) and muscle perfusion normalized by whole body perfusion (for quantifying the muscle’s active hyperemia). Twenty-eight human subjects participated in this Institutional Review Board-approved study, with 10 healthy subjects ( group A) for assessing interday reproducibility and 8 healthy subjects ( group B) for exploring the relationship between plantar-flexion load and induced muscle perfusion. In a pilot group of five elderly healthy subjects and five patients with PAD ( group C), we proposed a protocol that measured perfusion for a low-intensity exercise and for an exhaustion exercise in a single MRI session. In group A, perfusion estimates for calf muscles were highly reproducible, with correlation coefficients of 0.90–0.93. In group B, gastrocnemius perfusion increased linearly with the exercise workload ( P < 0.05). With the low-intensity exercise, patients with PAD in group C showed substantially lower gastrocnemius perfusion compared with elderly healthy subjects [43.4 (SD 23.5) vs. 106.7 (SD 73.2) ml·min−1·100 g−1]. With exhaustion exercise, G/S [1.0 (SD 0.4)] for patients with PAD was lower than both its low-intensity level [1.9 (SD 1.3)] and the level in elderly healthy subjects [2.7 (SD 2.1)]. In conclusion, the proposed MRI protocol and the new metrics are feasible for quantifying exercise-induced muscle hyperemia, a promising functional test of PAD. NEW & NOTEWORTHY To quantitatively map exercise-induced hyperemia in calf muscles, we proposed a high-resolution MRI method shown to be highly reproducible and sensitive to exercise load. With the use of low contrast, it is feasible to measure calf muscle hyperemia for both low-intensity and exhaustion exercises in a single MRI session. The newly proposed metrics for interpreting perfusion maps are promising for quantifying intermuscle vascular redistribution or a muscle’s active hyperemia.

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Section: Discussionmentioning

confidence: 99%

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Zhang

Layec

Hanrahan

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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“…Considering the acute increase of blood flow into the skeletal muscle during exercise, a vasodilatory defect due to failure of NO release might be an important pathophysiologic mechanism of elevated exercise blood pressure. During exercise tests, DBP may not increase or may often decrease, but SBP should increase at a steady rate as a function of rising oxygen demand and enhanced cardiac output, in relation to changes in peripheral vascular resistance that assure perfusion pressure needed in various active and inactive tissue beds . Tryfon et al indicated that even in the absence of daytime hypertension, normotensive OSAS patients demonstrate an elevation of BP during peak exercise .…”

Section: Discussionmentioning

confidence: 99%

Reduced exercise capacity in Greek children with mild to moderate obstructive sleep apnea syndrome

et al. 2012

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“…Acute exercise does not augment 24-h net rhGAA uptake in heart or quadriceps muscles of 6 neo /6 neo mice Since blood flow to contracting muscles increases 15-20-fold during exercise, and splanchnic-hepatic blood flow is significantly reduced [52,53], we hypothesized that 90 min of treadmill running would augment rhGAA uptake in the cardiac and hindlimb musculature of Pompe mice. Despite a sound theoretical framework supporting enhanced drug absorption in actively exercising tissues [53], we did not detect any differences in enzyme activity between ERT and EX +ERT groups 24 h post exercise (Fig.…”

Section: Resultsmentioning

confidence: 99%

Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease

Nilsson

Samjoo

Hettinga

et al. 2012

Molecular Genetics and Metabolism

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Regional Flow Responses to Exercise

Cited by 13 publications

References 7 publications

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

Reduced exercise capacity in Greek children with mild to moderate obstructive sleep apnea syndrome

Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease

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