2021
DOI: 10.1002/jmri.27662
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Regional Gas Exchange Measured by 129Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease

Abstract: Background Hyperpolarized 129Xe magnetic resonance imaging (MRI) provides a non‐invasive assessment of regional pulmonary gas exchange function. This technique has demonstrated that chronic obstructive pulmonary disease (COPD) patients exhibit ventilation defects, reduced interstitial barrier tissue uptake, and poor transfer to capillary red blood cells (RBCs). However, the behavior of these measurements following therapeutic intervention is unknown. Purpose To characterize changes in 129Xe gas transfer functi… Show more

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Cited by 16 publications
(13 citation statements)
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“…Nevertheless, it is known that IND/GLY improves COPD symptoms and lung function, and the 3 He and 1 H MRI-demonstrated changes in ventilation and perfusion may provide a mechanism to better explain the established clinical profile of dual bronchodilation. Consistent findings from a slightly smaller study using 129 Xe MRI support this notion [ 28 ].…”
Section: Discussionsupporting
confidence: 79%
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“…Nevertheless, it is known that IND/GLY improves COPD symptoms and lung function, and the 3 He and 1 H MRI-demonstrated changes in ventilation and perfusion may provide a mechanism to better explain the established clinical profile of dual bronchodilation. Consistent findings from a slightly smaller study using 129 Xe MRI support this notion [ 28 ].…”
Section: Discussionsupporting
confidence: 79%
“…Hence, in our study we were able to show that a broad and heterogeneous population of COPD patients benefit from dual bronchodilation in terms of improvements in ventilation homogeneity and V/Q mismatch. Apart from these fundamental methodological differences, the differing results between that study [ 28 ] and ours may also relate to the definition of the clinical cohort such as excluding patients with gross emphysema in our work. While degree of emphysema was not correlated with improvements in ventilation parameters following IND/GLY, it must be noted that our study does not determine whether patients with gross emphysema would benefit in a similar fashion.…”
Section: Discussionmentioning
confidence: 66%
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“…Paired inspiratory-expiratory CT may also be analysed for indirect functional biomarkers [ 20 ], such as small airways disease or gas trapping [ 21 , 22 ], and lung biomechanics [ 23 ]. In contrast, MRI using inhaled hyperpolarised gases ( 3 He or 129 Xe) provides direct functional information in the form of pulmonary ventilation distribution and gas exchange [ 24 ] that are highly abnormal and regionally heterogeneous in patients with COPD [ 25 , 26 ]. An important advantage of imaging over other approaches to biomarker discovery is the ability to capture regional heterogeneity in lung structure, function and physiology that is characteristic of COPD.…”
mentioning
confidence: 99%