Regional gray and white matter volume abnormalities in obsessive–compulsive disorder: A voxel-based morphometry study

Togao, Osamu; Yamada, Takashi; Nakao, Tomohiro; Nabeyama, Maiko; Sanematsu, Hirokuni; Nakagawa, Akiko; Noguchi, Tomoyuki; Hiwatashi, Akio; Yamashita, Koji; Nagao, Eiki; Kanba, Shigenobu; Honda, Hiroshi

doi:10.1016/j.pscychresns.2010.06.011

Cited by 77 publications

(66 citation statements)

References 73 publications

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“…We measured significantly lower gray matter volume in the right DLPFC in patients, consistent with previous VBM studies in adults [31,32] and children [33]. These results contrast with those of another VBM study reporting significantly lower gray matter volume in the left DLPFC in adult patients [34].…”

Section: Discussionsupporting

confidence: 87%

Structural brain abnormalities correlate with clinical features in patients with drug-naïve OCD: A DARTEL-enhanced voxel-based morphometry study

Tang

Huang

et al. 2015

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 87%

Structural brain abnormalities correlate with clinical features in patients with drug-naïve OCD: A DARTEL-enhanced voxel-based morphometry study

Tang

Huang

et al. 2015

Behavioural Brain Research

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“…A recent OCD Brain Imaging Consortium mega-analysis , involving 412 OCD patients and 368 healthy controls (HC), reported decreased white matter volumes in frontal regions in the patient group, suggesting abnormalities of white matter connections between the prefrontal and subcortical regions within the frontal-striatal circuits. These results were consistent with some previous studies on white matter volume (van den Heuvel et al, 2009;Togao et al, 2010). White matter volume alterations have also been reported for the parietal and occipital lobes (Riffkin et al, 2005;Lázaro et al, 2009Lázaro et al, , 2011.…”

Section: Introductionsupporting

confidence: 93%

Mild White Matter Changes in Un-Medicated Obsessive-Compulsive Disorder Patients and Their Unaffected Siblings

Fan

Heuvel

Cath

et al. 2017

European Neuropsychopharmacology

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Objective: Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disorder with moderate genetic influences and white matter abnormalities in frontal-striatal and limbic regions. Inconsistencies in reported white matter results from diffusion tensor imaging (DTI) studies can be explained, at least partly, by medication use and between-group differences in disease profile and stage. We used a family design aiming to establish whether white matter abnormalities, if present in un-medicated OCD patients, also exist in their unaffected siblings.Method: Forty-four OCD patients, un-medicated for at least the past 4 weeks, 15 of their unaffected siblings, and 37 healthy controls (HC) underwent DTI using a 3-Tesla MRI-scanner. Data analysis was done using tract-based spatial statistics (TBSS). Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values were compared within seven skeletonised regions of interest (ROIs), i.e., corpus callosum, bilateral cingulum bundle, bilateral inferior longitudinal fasciculus/ frontal-occipital fasciculus (ILF/FOF) and bilateral superior longitudinal fasciculus (SLF).Results: Un-medicated OCD patients, compared with HC, had significantly lower FA in the left cingulum bundle. FA was trend-significantly lower in all other ROIs, except for the corpus callosum. Significant three-group differences in FA (and in RD at trend-significant level) were observed in the left cingulum bundle, with the unaffected siblings representing an intermediate group between OCD patients and HC.Conclusions: OCD patients showed lower FA in the left cingulum bundle, partly driven by trend-significantly higher values in RD. Since the unaffected siblings were found to be an intermediate group between OCD patients and HC, this white matter alteration may be considered an endophenotype for OCD.

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“…Smaller volumes of the left and right inferior frontal gyrus extending to the anterior insula were reported once before in OCD (21) but are in contrast with other studies showing greater (e.g., reference 4) or normal (5,8) inferior frontal cortex/anterior insula volume. Our finding of smaller medial and inferior frontal white matter volumes bilaterally in OCD is notable considering inconsistent previous reports (e.g., references [8][9][10] and converges with studies showing altered frontal-striatal white matter microstructure in OCD (5). Frontal volume changes may be related to impairments in cognitive functions that have been with healthy subjects Linear, nonlinear: ns a Linear (age) and nonlinear (age squared) group-by-age interaction analysis thresholded at p,0.001 uncorrected and a minimum cluster extent (k e ) of 100 voxels.…”

Section: Frontal and Cerebellar Volume Changes In Ocdsupporting

confidence: 55%

“…Greater striatal volume is often found in OCD patients compared with healthy subjects (2-5), whereas reports on gray matter volume alterations outside the frontal-striatal circuit in OCD are less consistent (2)(3)(4)(5). The involvement of white matter volume alterations in OCD remains unclear as well, with either nonsignificant findings (e.g., reference 8), smaller dorsal frontal (9, 10) and temporal white matter volume (11), or greater ventral frontal white matter volume (10). Although white matter volume information is automatically available in voxel-based morphometry, many studies do not report such findings, suggesting a reporting bias.…”

mentioning

confidence: 99%

Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

Wit

Alonso

Schweren

et al. 2015

FOC

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Objective: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables.Method: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T structural T 1 -weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects.

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Regional gray and white matter volume abnormalities in obsessive–compulsive disorder: A voxel-based morphometry study

Cited by 77 publications

References 73 publications

Structural brain abnormalities correlate with clinical features in patients with drug-naïve OCD: A DARTEL-enhanced voxel-based morphometry study

Structural brain abnormalities correlate with clinical features in patients with drug-naïve OCD: A DARTEL-enhanced voxel-based morphometry study

Mild White Matter Changes in Un-Medicated Obsessive-Compulsive Disorder Patients and Their Unaffected Siblings

Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

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