Regional gray matter abnormalities in pre-adolescent binge eating disorder: A voxel-based morphometry study

Murray, Stuart B.; Duval, Christina J.; Balkchyan, Ane A; Cabeen, Ryan P.; Nagata, Jason M.; Toga, Arthur W.; Siegel, Steven J.; Jann, Kay

doi:10.1016/j.psychres.2022.114473

Cited by 13 publications

(20 citation statements)

References 69 publications

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“…However, the implication of these results for reward processing is unclear. The studies in this review find a relation between a higher OFC volume and a lower reward sensitivity in adolescence, but the opposite in adults (Frank et al, 2013; Murray, Duval, et al, 2022). Furthermore, a higher volume of the putamen and globus pallidus is predictive of developing BE, but no difference in the volume of these regions is found in individuals who have BE episodes (Zhang et al, 2021).…”

Section: Discussionmentioning

confidence: 71%

“…Most studies used voxel‐based morphometry (VBM; n = 11 studies, 79%) while others used surface‐based morphometry (SBM; n = 2, 14%) or a manual segmentation technique ( n = 1, 7%). Across the samples, the studies found a lower volume of the CN ( n = 4 studies, 29%) as well as a higher volume of the medial/total OFC ( n = 4, 29%), right ventral striatum/NAc ( n = 2, 14%), left insula ( n = 2, 14%), left postcentral gyrus ( n = 2, 14%), and ACC ( n = 2, 14%) (Amianto et al, 2013; Coutinho et al, 2014; Frank et al, 2013; Murray, Duval, et al, 2022; Schäfer et al, 2010; Turan et al, 2021; Voon et al, 2015). There were two (14%) studies that followed participants longitudinally (Cyr et al, 2017; Zhang et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…One of these reported that a higher volume of the right putamen and globus pallidus at age 14 was predictive of developing BE in the next 2 to 5 years (Zhang et al, 2021). Only two (14%) studies investigated the relationship between volume and reward processing (Frank et al, 2013; Murray, Duval, et al, 2022). Although both studies found a higher OFC volume, one study did so in adult patients with a higher reward sensitivity while another study in adolescents found an association with lower behavioral approach scores (i.e., the drive to approach rewards) (Murray, Duval, et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

“…Only two (14%) studies investigated the relationship between volume and reward processing (Frank et al, 2013; Murray, Duval, et al, 2022). Although both studies found a higher OFC volume, one study did so in adult patients with a higher reward sensitivity while another study in adolescents found an association with lower behavioral approach scores (i.e., the drive to approach rewards) (Murray, Duval, et al, 2022). This could indicate that the relationship between volume and reward processing differs depending on the age or illness duration of the patient.…”

Section: Resultsmentioning

confidence: 99%

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The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

Leenaerts

Jongen

Ceccarini

et al. 2022

Intl J Eating Disorders

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Objective Changes in reward processing are hypothesized to play a role in the onset and maintenance of binge eating (BE). However, despite an increasing number of studies investigating the neurobiological reward system in individuals who binge eat, no comprehensive systematic review exists on this topic. Therefore, this review has the following objectives: (1) identify structural and functional changes in the brain reward system, either during rest or while performing a task; and (2) formulate directions for future research. Methods A search was conducted of articles published until March 31, 2022. Neuroimaging studies were eligible if they wanted to study the reward system and included a group of individuals who binge eat together with a comparator group. Their results were summarized in a narrative synthesis. Results A total of 58 articles were included. At rest, individuals who binge eat displayed a lower striatal dopamine release, a change in the volume of the striatum, frontal cortex, and insula, as well as a lower frontostriatal connectivity. While performing a task, there was a higher activity of the brain reward system when anticipating or receiving food, more model‐free reinforcement learning, and more habitual behavior. Most studies only included one patient group, used general reward‐related measures, and did not evaluate the impact of comorbidities, illness duration, race, or sex. Discussion Confirming previous hypotheses, this review finds structural and functional changes in the neurobiological reward system in BE. Future studies should compare disorders, use measures that are specific to BE, and investigate the impact of confounding factors. Public Significance Statement This systematic review finds that individuals who binge eat display structural and functional changes in the brain reward system. These changes could be related to a higher sensitivity to food, relying more on previous experiences when making decisions, and more habitual behavior. Future studies should use a task that is specific to binge eating, look across different patient groups, and investigate the impact of comorbidities, illness duration, race, and sex.

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Section: Discussionmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

Leenaerts

Jongen

Ceccarini

et al. 2022

Intl J Eating Disorders

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“…We think that one of the ways that depression indirectly influences dysmenorrhea through binge eating is that depressed people may prefer to eat to soothe an unpleasant mood, and that both binge eating and depression may lead to endocrine abnormalities that cause or worsen dysmenorrhea. A previous study has shown that the gray matter volume increases in the left anterior abdominal insula of people with binge eating behavior, causing hypersensitivity [ 44 ], which may aggravate the uncomfortable feeling of dysmenorrhea. Depressed people have elevated cortisol levels [ 45 ], elevated cortisol levels increase food intake [ 46 ], which may contribute to the significant positive relationship between depression and binge eating behavior.…”

Section: Discussionmentioning

confidence: 99%

Association between depression and dysmenorrhea among adolescent girls: multiple mediating effects of binge eating and sleep quality

Kang

Zhao

et al. 2023

BMC Women's Health

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Background Dysmenorrhea has a significant negative impact on teenagers’ quality of life, and its prevalence is increasing annually. Although studies have explored the factors affecting dysmenorrhea, it remains unclear how these factors interact with one another. This study aimed to explore the mediating role of binge eating and sleep quality between depression and dysmenorrhea. Methods This cross-sectional study recruited adolescent girls from the Health Status Survey of adolescents in Jinan, Shandong Province, and used multistage stratified cluster random sampling. Data was collected using an electronic questionnaire between March 9, 2022, and June 20, 2022. The Numerical Rating Scale and Cox Menstrual Symptom Scale were used to assess dysmenorrhea and the Patient Health Questionnaire-9 to assess depression. The mediation model was tested by Mplus 8.0, and the mediating effect was analyzed using the Product of Coefficients approach and the Bootstrap method. Results Among the total of 7818 adolescent girls included in this study, the prevalence of dysmenorrhea is 60.5%. A significant positive association was found between dysmenorrhea and depression. Binge eating and sleep quality seemingly mediate this association. The mediating effect of sleep quality (21.31%) was greater than that of binge eating (6.18%). Conclusions The findings of this study point in the right direction for preventing and treating dysmenorrhea in adolescents. For adolescent dysmenorrhea, mental health should be considered and proactive steps taken for educating adolescents on healthy lifestyles to reduce negative consequences of dysmenorrhea. Longitudinal studies on the causal link and influence mechanisms between depression and dysmenorrhea should be conducted in the future.

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Neuroimaging and Eating Disorders

Koithan,

King,

Ehrlich

et al. 2023

Eating Disorders

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Regional gray matter abnormalities in pre-adolescent binge eating disorder: A voxel-based morphometry study

Cited by 13 publications

References 69 publications

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

Association between depression and dysmenorrhea among adolescent girls: multiple mediating effects of binge eating and sleep quality

Neuroimaging and Eating Disorders

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