Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry

Takeuchi, Hikaru; Taki, Yasuyuki; Nouchi, Rui; Sekiguchi, Atsushi; Kotozaki, Yuka; Miyauchi, Carlos Makoto; Yokoyama, Ryoichi; Iizuka, Kunio; Hashizume, Hiroshi; Nakagawa, Seishu; Kunitoki, Keiko; Sassa, Yuko; Kawashima, Ryuta

doi:10.1007/s00429-012-0485-3

Cited by 113 publications

(78 citation statements)

References 77 publications

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“…2 Third, areas in the basal ganglia, orbitofrontal cortex and insula have various roles in reward and motivation processes. 34, 35 Interestingly, similar to psychostimulants, VGP causes substantial dopamine release in the dopaminergic system 5 and causes addiction. 6 Dopamine has been known to exhibit neurotoxic properties, and excessive dopamine damages tissues and cells in the brain.…”

Section: Discussionmentioning

confidence: 99%

Impact of videogame play on the brain’s microstructural properties: cross-sectional and longitudinal analyses

et al. 2016

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Videogame play (VGP) has been associated with numerous preferred and non-preferred effects. However, the effects of VGP on the development of microstructural properties in children, particularly those associated with negative psychological consequences of VGP, have not been identified to date. The purpose of this study was to investigate this issue through cross-sectional and longitudinal prospective analyses. In the present study of humans, we used the diffusion tensor imaging mean diffusivity (MD) measurement to measure microstructural properties and examined cross-sectional correlations with the amount of VGP in 114 boys and 126 girls. We also assessed correlations between the amount of VGP and longitudinal changes in MD that developed after 3.0±0.3 (s.d.) years in 95 boys and 94 girls. After correcting for confounding factors, we found that the amount of VGP was associated with increased MD in the left middle, inferior and orbital frontal cortex; left pallidum; left putamen; left hippocampus; left caudate; right putamen; right insula; and thalamus in both cross-sectional and longitudinal analyses. Regardless of intelligence quotient type, higher MD in the areas of the left thalamus, left hippocampus, left putamen, left insula and left Heschl gyrus was associated with lower intelligence. We also confirmed an association between the amount of VGP and decreased verbal intelligence in both cross-sectional and longitudinal analyses. In conclusion, increased VGP is directly or indirectly associated with delayed development of the microstructure in extensive brain regions and verbal intelligence.

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Section: Discussionmentioning

confidence: 99%

Impact of videogame play on the brain’s microstructural properties: cross-sectional and longitudinal analyses

et al. 2016

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“…With respect to structural imaging, gray matter density of the orbitofrontal cortex has also been associated with self-fulfillment achievement motivation in healthy individuals (Takeuchi et al 2014). In patients with schizophrenia, Venkatasubramanian et al (2008) found that lower left MOFC thickness was associated with higher negative symptom severity.…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

et al. 2017

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Background. Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity. Results. Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (β std = −0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.Conclusions. Using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.

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“…In food-rich environments, the long-term goal of weight control as a self-regulation process requires more cognitive resources than the proximal goal of food enjoyment does. There is evidence that both (i) proactive self-control efforts in response to immediate temptations and (ii) externally-imposed controls can help to protect long-term interests such as losing or maintaining weight (Takeuchi et al, 2014). However, it is plausible that weak self-control efforts and/or lack of responsiveness to external controls in response to immediate temptations impair one's ability to monitor or inhibit inappropriate behavior, consequently disrupting long-term weight control goals.…”

Section: Discussionmentioning

confidence: 99%

“…Following other published accounts (Ledberg et al, 1998; Takeuchi et al, 2014), in whole-brain analyses we used multiple linear regression analyses to identify regions in which regional gray matter volume (rGMV) was associated with RS scores. To control for possible confounding variables, BMI, age, gender and global GMV were entered as covariates within the regression model.…”

Section: Methodsmentioning

confidence: 99%

Regional Gray Matter Volume Is Associated with Restrained Eating in Healthy Chinese Young Adults: Evidence from Voxel-Based Morphometry

Jackson

Wei

et al. 2017

Front. Psychol.

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Highlight Participants were non-clinical young adults with different restrained eating levels.We assessed relations of restrained eating (RE) with regional gray matter volume (rGMV).High RE scores were related to larger GMV in specific areas related to reward.High RE scores were also linked to less GMV in regions related to response inhibition. Objective: Dieting is a popular method of weight control. However, few dieters are able to maintain initial weight losses over an extended period of time. Why do most restrained dieters fail to lose weight? Alterations in brain structures associated with restrained eating (RE) represent one potentially important mechanism that contributes to difficulties in maintaining weight loss within this group. To evaluate this contention, we investigated associations between intentional, sustained restriction of food intake to lose or maintain body weight, and regional gray matter volume (rGMV) within a large non-clinical young adult, sample.Methods: Participants (150 women, 108 men) completed measures of RE and demographics prior to undergoing an MRI scan. Voxel-based morphometry (VBM) evaluated strengths of association between RE scores and rGMV.Results: Higher RE levels corresponded to more rGMV in regions linked to risk of overeating and binge-eating including the left insula and orbitofrontal cortex (OFC). Conversely, RE had significant negative correlations with rGMV in the left and right posterior cingulum gyrus, regions linked to inhibitory control and potential risk for future weight gain.Conclusions: Together, findings suggested individual differences in RE among young adults correspond to GMV variability in regions linked to overweight and obesity risk.

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Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry

Cited by 113 publications

References 77 publications

Impact of videogame play on the brain’s microstructural properties: cross-sectional and longitudinal analyses

Impact of videogame play on the brain’s microstructural properties: cross-sectional and longitudinal analyses

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

Regional Gray Matter Volume Is Associated with Restrained Eating in Healthy Chinese Young Adults: Evidence from Voxel-Based Morphometry

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