Regional haemodynamic effects of depressor neuropeptides in conscious, unrestrained, Long Evans and Brattleboro rats

Gardiner, Sheila M.; Compton, A.M.; Bennett, T.

doi:10.1111/j.1476-5381.1988.tb16565.x

Cited by 46 publications

(32 citation statements)

References 30 publications

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“…Indeed, recent findings indicate that indomethacin reduces the contractile effects of endothelin-I on rat aorta (Eglen et al, 1989). In addition, it seems unlikely that the hindquarters hyperaemic responses to bolus doses of endothelin-1 are dependent upon release of atrial natriuretic peptide (Winquist et al, 1989), since bolus doses of this peptide do not cause significant increases in hindquarters blood flow in Brattleboro rats (Gardiner et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…Animals were given an intramuscular injection of ampicillin (Penbritin 7mg kg-1) and allowed to recover for at least 7 days with free access to food and water. Then (Haywood et al, 1981;Gardiner et al, 1988) and together with mean blood pressure (BP) can be used to calculate percentage changes in vascular resistances.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, any differences in sensitivity to the vasoconstrictor actions of endothelins between Long Evans and Brattleboro rats could be of relevance to our understanding of the role of endogenous endothelin in cardiovascular regulation. Furthermore, since it has been suggested that release of atrial natriuretic peptide might be responsible for the hypotensive and vasodilator effects of endothelin-1 (Winquist et al, 1989), com-parison of the responses of Long Evans and Brattleboro rats to this peptide should provide results germane to this hypoth-esis because atrial natriuretic peptide increases hindquarters blood flow in Long Evans, but not in Brattleboro rats (Gardiner et al, 1988). Some of these results have been presented to the British Pharmacological Soc~ety (Gardiner et al, 1989b).…”

Section: Introductionmentioning

confidence: 99%

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Regional haemodynamic effects of endothelin‐1 and endothelin‐3 in conscious Long Evans and Brattleboro rats

Gardiner

Compton

Bennett

1990

British J Pharmacology

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1 The regional haemodynamic effects of bolus doses (4 and 40 pmol) and infusions (12 and 120 pmol h1) of endothelin-1 and endothelin-3 were assessed in conscious, Long Evans and Brattleboro (i.e. vasopressin-deficient) rats, chronically-instrumented with pulsed Doppler flow probes. 2 In both strains of rat the lower bolus dose of endothelin-1 caused only a slight pressor effect, but there were marked renal and mesenteric vasoconstrictions and hindquarters vasodilatation. 3 The lower bolus dose of endothelin-3 did not affect blood pressure significantly, although the changes in regional haemodynamics were qualitatively similar to those seen following endothelin-1 in Long Evans and Brattleboro rats. 4 The higher dose of endothelin-1 caused an initial hypotension accompanied by substantial hindquarters vasodilatations in Long Evans and Brattleboro rats. Subsequently, in both strains, there was a rise in blood pressure accompanied by renal, mesenteric and hindquarters vasoconstrictions. 5 The higher bolus dose of endothelin-3 caused initial hypotension and hindquarters vasodilatation similar to those seen with endothelin-1. However, the subsequent pressor effect was less with endothelin-3, as was the renal vasoconstriction, and it did not cause any increase in hindquarters vascular resistance. 6 Infusion of endothelin-l at the lower rate (12 pmol h-1) caused renal and mesenteric vasoconstrictions in both strains of rat, whereas endothelin-3 at this rate caused only mesenteric vasoconstriction. 7 Infusion of endothelin-1 at the higher rate (120 pmolh 1) caused progressive hypertension and vasoconstrictions in all three vascular beds studied; these were similar in both strains of rat. Endothelin-3 had a smaller pressor effect and a lesser constrictor action on the renal and mesenteric vascular beds; it did not constrict the hindquarters vascular bed. 8 These results show, that in conscious Long Evans and Brattleboro rats, the initial depressor effects of the higher bolus doses of endothelin-1 and -3 were similar, and, hence, not influenced by the absence of endogenous vasopressin. Endothelin-1 and -3 appear equipotent in their initial hyperaemic vasodilator effects in the hindquarters vasculature in both strains, making it unlikely that this effect is dependent on the release of atrial natriuretic peptide (ANP), since ANP does not cause significant increases in hindquarters blood flow in Brattleboro rats. The greater delayed pressor effect of endothelin-1 is associated with its more marked vasoconstrictor effects on renal and mesenteric vascular beds and is accentuated, relative to endothelin-3, by the lack of a constrictor effect of endothelin-3 in the hindquarters vasculature.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regional haemodynamic effects of endothelin‐1 and endothelin‐3 in conscious Long Evans and Brattleboro rats

Gardiner

Compton

Bennett

1990

British J Pharmacology

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“…The latter have been shown to be a good index of volume flow (Haywood et al, 1981;Wright et al, 1987), and are referred to as flows in the text. Changes in Doppler shift signals and vascular resistances were calculated as percentages relative to baseline (Haywood et al, 1981;Gardiner et al, 1988b).…”

Section: C) the Macmillan Press Ltd 1989mentioning

confidence: 99%

Regional haemodynamic effects of vasopressin infusion in conscious, unrestrained, Brattleboro rats

Gardiner

Compton

Bennett

1989

British J Pharmacology

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“…[1][2][3] These responses are associated with sustained vasodilatation in a number of tissues. 1,2 Recent investigations of the underlying mechanisms of these responses using isolated preparations have shown the vasodilator effect of CRF to involve both a direct action on vascular smooth muscle and a prolonged endothelium-dependent response due to the sustained release of nitric oxide (NO). 4 In the experiments described here, the role of endothelium derived NO release in the sustained hypotensive effect of CRF has been evaluated using the NO synthase inhibitor N G -Nitro-L-arginine Methyl Ester (L-NAME) in anaesthetised rats.…”

Section: Introductionmentioning

confidence: 99%

Corticotrophin releasing factor attenuates NG-Nitro-L-arginine Methyl Ester induced increases in blood pressure in the anaesthetised rat

Corder

1999

J Hum Hypertens

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Regional haemodynamic effects of depressor neuropeptides in conscious, unrestrained, Long Evans and Brattleboro rats

Cited by 46 publications

References 30 publications

Regional haemodynamic effects of endothelin‐1 and endothelin‐3 in conscious Long Evans and Brattleboro rats

Regional haemodynamic effects of endothelin‐1 and endothelin‐3 in conscious Long Evans and Brattleboro rats

Regional haemodynamic effects of vasopressin infusion in conscious, unrestrained, Brattleboro rats

Corticotrophin releasing factor attenuates NG-Nitro-L-arginine Methyl Ester induced increases in blood pressure in the anaesthetised rat

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