Regional homogeneity associated with overgeneral autobiographical memory of first-episode treatment-naive patients with major depressive disorder in the orbitofrontal cortex: A resting-state fMRI study

Zhao, Xudong; Zhang, Cheng; Zhang, Fuquan; Chang, Jun; Wang, Haosen; Xie, Rukui; Wang, Zhiqiang; Cao, Leiming; Wang, Guoqiang

doi:10.1016/j.jad.2016.11.044

Cited by 17 publications

(5 citation statements)

References 47 publications

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“…However, Peiffer et al [28] explored dyspnea-related brain activation in healthy subjects, and the altered activity in the insula was not found during dyspnea. Although the anterior insula is a critical brain region involved in the experience of negative emotions [29], many fMRI research of depression did not report abnormal activity in the insula [30, 31]. These findings further supported our study that significant differences of ReHo in the insula were not found between the DA and NDA patients.…”

Section: Discussionsupporting

confidence: 89%

Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

et al. 2017

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Objective To explore the underlying mechanism of depression in asthmatic patients, the ReHo in the insula and its FC was used to probe the differences between depressed asthmatic (DA) and nondepressed asthmatic (NDA) patients. Methods 18 DA patients, 24 NDA patients, and 60 healthy controls (HCs) received resting-state fMRI scan, severity of depression, and asthma control assessment. Results DA patients showed increased FC between the left ventral anterior insula (vAI) and the left middle temporal gyrus compared with both NDA and HC groups. In addition, compared with HCs, the DA and NDA patients both exhibited increased FC between the left vAI and the right anterior cingulate cortex (ACC), decreased FC between the left vAI and the bilateral parietal lobe, and increased FC between the right vAI and the left putamen and the right caudate, respectively. Furthermore, the increased FC between the left vAI and the right ACC could differentiate HCs from both DA and NDA patients, and the increased FC between the right vAI and both the left putamen and the right caudate could separate NDA patients from HCs. Conclusions This study confirmed that abnormal vAI FC may be involved in the neuropathology of depression in asthma. The increased FC between the left vAI and the left MTG could distinguish DA from the NDA and HC groups.

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Section: Discussionsupporting

confidence: 89%

Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

et al. 2017

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“…Some previous structural studies had revealed significant OFC volume decrease in patients with depression ( 67 , 68 ). Meanwhile, several resting-state fMRI and PET studies also reported that MDD patients showed decreased ReHo and regional cerebral blood flow in the OFC ( 69 – 72 ). Besides, Chen et al revealed that the connectome alterations in the OFC among MDD patients may result from abnormalities in brain regional volume, WM tract integrity, and functional connectivity between brain structures ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration

et al. 2017

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It is crucial to explore the pathogenesis of major depressive disorder (MDD) at the early stage for the better diagnostic and treatment strategies. It was suggested that MDD might be involving in functional or structural alternations at the brain network level. However, at the onset of MDD, whether the whole brain white matter (WM) alterations at network level are already evident still remains unclear. In the present study, diffusion MRI scanning was adopt to depict the unique WM structural network topology across the entire brain at the early stage of MDD. Twenty-one first episode, short duration (<1 year) and drug-naïve depression patients, and 25 healthy control (HC) subjects were recruited. To construct the WM structural network, atlas-based brain regions were used for nodes, and the value of multiplying fiber number by the mean fractional anisotropy along the fiber bundles connected a pair of brain regions were used for edges. The structural network was analyzed by graph theoretic and network-based statistic methods. Pearson partial correlation analysis was also performed to evaluate their correlation with the clinical variables. Compared with HCs, the MDD patients had a significant decrease in the small-worldness (σ). Meanwhile, the MDD patients presented a significantly decreased subnetwork, which mainly involved in the frontal–subcortical and limbic regions. Our results suggested that the abnormal structural network of the orbitofrontal cortex and thalamus, involving the imbalance with the limbic system, might be a key pathology in early stage drug-naive depression. And the structural network analysis might be potential in early detection and diagnosis of MDD.

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“…Enhanced ECs were also observed from the THA to the limbic system [e.g., the ORBsupmed and ORBmid parts of the orbitofrontal cortex (OFC), AMYG, and HIP], whereas reduced ECs were found in the opposite direction. The OFC plays a crucial role in several psychiatric and neurological disorders because of its involvement in a wide range of psychological functions such as emotional processing and regulation ( Gilbert et al, 2010 ), autobiographical memory ( Liu et al, 2017 ), decision-making ( Bechara et al, 2000 ), and integration of sensory information ( Price, 1999 ). The gray matter volume of the OFC in MDD patients is reduced, which may lead to inefficient suppression of excessive negative emotions from the THA and reduced ECs to THA via anatomical connection ( Kringelbach, 2005 , Wagner et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

The thalamus is the causal hub of intervention in patients with major depressive disorder: Evidence from the Granger causality analysis

Yang

Xiao

et al. 2023

NeuroImage: Clinical

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Regional homogeneity associated with overgeneral autobiographical memory of first-episode treatment-naive patients with major depressive disorder in the orbitofrontal cortex: A resting-state fMRI study

Cited by 17 publications

References 47 publications

Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration

The thalamus is the causal hub of intervention in patients with major depressive disorder: Evidence from the Granger causality analysis

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