Regional Homogeneity Changes in Nicotine Addicts by Resting-State fMRI

Chen, Hongbo; Mo, Shaofeng

doi:10.1371/journal.pone.0170143

Cited by 10 publications

(12 citation statements)

References 35 publications

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“…Therefore, both BMI and CPD of MADs were higher than HCs. Although both CPD and BMI showed influence in ReHo and fALFF in several brain regions 47 , 85 , 89 – 91 , these alterations could not explain all the results in our study. Furthermore, we included BMI and CPD as covariates to control these effects in the analysis.…”

Section: Discussioncontrasting

confidence: 85%

Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Xie

Yang

et al. 2021

Sci Rep

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Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.

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Section: Discussioncontrasting

confidence: 85%

Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Xie

Yang

et al. 2021

Sci Rep

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“…Then we performed AFNI’s AlphaSim program 1 to correct for multiple comparisons. We ran 1000 Monte Carlo simulations with voxel-level p < 0.005, cluster size > 87, corresponding to a corrected p < 0.05 as determined by AlphaSim correction ( Yang et al, 2016 ; Chen and Mo, 2017 ). The FWHM of the individual t-maps was used as the Gaussian filter, along with a cluster connection radius of 5 mm, as previous studies have demonstrated that 1000 simulations are adequate for an fMRI study ( Brass et al, 2007 ; Chen et al, 2013 ).…”

Section: Methodsmentioning

confidence: 99%

Priming the Secure Attachment Schema Affects the Emotional Face Processing Bias in Attachment Anxiety: An fMRI Research

Tang

Chen

et al. 2017

Front. Psychol.

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Our study explored how priming with a secure base schema affects the processing of emotional facial stimuli in individuals with attachment anxiety. We enrolled 42 undergraduate students between 18 and 27 years of age, and divided them into two groups: attachment anxiety and attachment secure. All participants were primed under two conditions, the secure priming using references to the partner, and neutral priming using neutral references. We performed repeated attachment security priming combined with a dual-task paradigm and functional magnetic resonance imaging. Participants’ reaction times in terms of responding to the facial stimuli were also measured. Attachment security priming can facilitate an individual’s processing of positive emotional faces; for instance, the presentation of the partner’s name was associated with stronger activities in a wide range of brain regions and faster reaction times for positive facial expressions in the subjects. The current finding of higher activity in the left-hemisphere regions for secure priming rather than neutral priming is consistent with the prediction that attachment security priming triggers the spread of the activation of a positive emotional state. However, the difference in brain activity during processing of both, positive and negative emotional facial stimuli between the two priming conditions appeared in the attachment anxiety group alone. This study indicates that the effect of attachment secure priming on the processing of emotional facial stimuli could be mediated by chronic attachment anxiety. In addition, it highlights the association between higher-order processes of the attachment system (secure attachment schema priming) and early-stage information processing system (attention), given the increased attention toward the effects of secure base schema on the processing of emotion- and attachment-related information among the insecure population. Thus, the following study has applications in providing directions for clinical treatment of mood disorders in attachment anxiety.

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“…Chen et al. further found decreased ReHo in the superior frontal gyrus (SFG) and precuneus, and the decreased ReHo value in the precuneus was positively correlated with the Fagerström Test for Nicotine dependence (FTND) scores, an important index for clinical evaluation of smoker’s dependence on nicotine addiction ( 26 ). Using fractional ALFF technology, enhanced neural spontaneous activity was found in the caudate of young smokers ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

“…In the context of nicotine addiction, numerous rs-fMRI studies have focused on the properties of regional neural activity (12,(25)(26)(27)(28). For example, compared with nonsmokers, Yu and his colleague discovered that heavy smokers exhibited decreased ReHo in the prefrontal regions and increased ReHo in the insula and posterior cingulate cortex (PCC) (12).…”

Section: Introductionmentioning

confidence: 99%

Dynamic Neuroimaging Biomarkers of Smoking in Young Smokers

et al. 2020

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Objective To examine potential changes in the dynamic characteristics of regional neural activity in young smokers and to detect whether the changes were associated with smoking behavior. Methods The dynamic regional homogeneity (dReHo) and dynamic amplitude of low-frequency fluctuations (dALFF) in 40 young smokers and 42 nonsmokers were compared. Correlation analyses were also performed between dReHo and dALFF in areas showing group differences and smoking behavior [e.g., the Fagerström Test for Nicotine dependence (FTND) scores and pack-years]. Results Significantly differences in dReHo variability were observed in the inferior frontal gyrus (IFG), superior frontal gyrus (SFG), medial frontal gyrus (MFG), insula, cuneus, postcentral gyrus, inferior semi-lunar lobule, orbitofrontal gyrus, and inferior temporal gyrus (ITG). Young smokers also showed significantly increased dALFF variability in the anterior cingulate cortex (ACC) and ITG. Furthermore, a significant positive correlation was found between dALFF variability in the ACC and the pack-years; whereas a significant negative correlation between dReHo variability in the IFG and the FTND scores was found in young smokers. Conclusion The pattern of resting state regional neural activity variability was different between young smokers and nonsmokers. Dynamic regional indexes might be a novel neuroimaging biomarker of smoking behavior in young smokers.

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Regional Homogeneity Changes in Nicotine Addicts by Resting-State fMRI

Cited by 10 publications

References 35 publications

Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Priming the Secure Attachment Schema Affects the Emotional Face Processing Bias in Attachment Anxiety: An fMRI Research

Dynamic Neuroimaging Biomarkers of Smoking in Young Smokers

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