The article focuses on the problems of innovation security of western border regions of Russia within the conditions of geo-economic turbulence after 2014. The developed and polycriteria typology is urgent due to purposes of decision-making support of innovation sector after the shift of conditions and the grown need for import substitution. Several interconnected typologies are proposed within the study, basing on several criteria. The research involves both quantitative and qualitative data on 15 western border regions of Russia. The implementation of dynamic approach to study innovation security (previously developed by the author) allowed tracing 11 statistic indicators on all the stages of innovation process. These stages are: the potential of primary conditions for research activities, the sector of patenting, the organizational R&D activities, the production and consumption of innovations and the final volume and share of innovatively produced goods and services. The assessment is given in static and dynamic extent (including the comparison of 4-year periods before and after 2014). The use of dynamic approach pointed out the changes in grouping regions at each of the consequent stages of innovation process. Some regions are developed at the initial stage; other ones are faster developing in implementation of innovations. Also the study involves qualitative data on innovation clustering and regional strategies (which mark the goals, expectations and view on innovations by regional administrations and communities). The research results in the general complex classification, which reflects the picture of involvement of the regions into innovation process, their main problems and strength.