Regional Intestinal Blood Flow in Ulcerative Colitis and Crohn's Disease

Hultén, L.; Lindhagen, J; Lundgren, Ove; Fasth, S.; Åhrén, C

doi:10.1016/s0016-5085(77)80245-x

Cited by 145 publications

(68 citation statements)

References 21 publications

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“…8 These in¯ammatory responses are similar to those seen in Crohn's ileitis. 13 The alterations of motility in this model of in¯ammation, Figure 7 Close-intra-arterial infusions of angiotensin II signi®cantly increased mesenteric arterial blood¯ow in the normal and the in¯amed ileum, but it had no signi®cant effect on the blood¯ow in the superior mesenteric artery. Angiotensin II also stimulated a series of contractions in some dogs, but the start or the duration of these contractions were not related to the start of decrease in blood¯ow, its magnitude, or its duration.…”

Section: Discussionmentioning

confidence: 82%

Interaction between blood flow and motility in normal and inflamed ileum

Cowles

Ryan

Sarna

1999

Neurogastroenterology Motil

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The alterations in local and superior mesenteric blood flow during ileal inflammation and their correlations with motility in the normal and the inflamed ileum were investigated in the conscious state. Ileal inflammation decreased the local mesenteric blood flow but had no significant effect on the superior mesenteric blood flow. A significant reduction or an increase in local mesenteric blood flow in the normal or the inflamed ileum had no effect on local contractile activity. The vascular reactivity to vaso-dilators and vaso-constrictors was significantly reduced during inflammation. Local mesenteric blood flow increased significantly in the descending segment ahead of a caudal propagating giant migrating contraction. The local mesenteric blood flow oscillated during a migrating motor complex (MMC) cycle. We conclude that a several-fold increase or decrease in local mesenteric blood flow lasting for several minutes does not affect contractility. Ileal inflammation decreases local mesenteric blood flow but does not affect the total blood flow to the small intestine.

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Section: Discussionmentioning

confidence: 82%

Interaction between blood flow and motility in normal and inflamed ileum

Cowles

Ryan

Sarna

1999

Neurogastroenterology Motil

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“…Early angiographic and histopathologic studies revealed increased vascularity within the normal mucosa and submucosa but reduced muscularis blood flow in active disease, which tended to decrease further in the late fibrosing stage. 15,16 More recently, detailed descriptions of microvascular inflammation with focal arteritis, tissue infarction, and neovascularization stressed the important role of vasculature in the etiology of Crohn disease. 17,18 Instead of invasive methods, Doppler ultrasonography can reveal the increased splanchnic blood flow with the affected small-bowel segment changes in inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

Crohn Disease Activity Evaluated by Doppler Ultrasonography of the Superior Mesenteric Artery and the Affected Small-Bowel Segments

Yekeler

Danalıoğlu

Movasseghi

et al. 2005

Journal of Ultrasound in Medicine

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“…Attempts to characterize alterations in intestinal blood flow in IBD have been utilized both direct and indirect methods. In 1977, Hulten et al demonstrated in chronically inflamed tissues (both chronically active and quiescent disease) diminished gut perfusion compared with controls, which correlated with histological evidence of persistent ulceration and intestinal fibrosis [14]. Angerson et al demonstrated similar findings using endoscopic Doppler laser flowmetry, where chronically inflamed CD bowel demonstrated significantly decreased perfusion [32].…”

Section: Diminished Mucosal Perfusion -Intraoperative and Endoscopic mentioning

confidence: 96%

Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease

Hatoum

Binion

Gutterman

2005

Eur J Clin Investigation

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This review has focused on evidence regarding intestinal perfusion of inflammatory bowel disease (IBD). Basic investigation has defined an altered microvascular anatomy in the affected IBD bowel, which corresponds with diminished mucosal perfusion in the setting of chronic, long-standing inflammation. Diminished perfusion is linked to impaired wound healing, and may contribute to the continued refractory mucosal damage, which characterizes IBD. Alterations in vascular anatomy and physiology in IBD suggests additional possible mechanisms by which micro-vessels may contribute to the initiation and perpetuation of IBD. This begs the following questions: will angiogenesis within the gut lead to sustained inflammation, does the growing vasculature generate factors that transform the surrounding tissue and does angiogenesis generate vascular anastomosis within the gut, with shunting of blood away from the mucosal surface, impairment of metabolism and potentiation of gut damage? Further studies are required to define the mechanisms that underlie the vascular dysfunction and its role in pathophysiology of IBD.

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Regional Intestinal Blood Flow in Ulcerative Colitis and Crohn's Disease

Cited by 145 publications

References 21 publications

Interaction between blood flow and motility in normal and inflamed ileum

Interaction between blood flow and motility in normal and inflamed ileum

Crohn Disease Activity Evaluated by Doppler Ultrasonography of the Superior Mesenteric Artery and the Affected Small-Bowel Segments

Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease

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