Regional localization of the gene encoding pregnancy specific beta-1-glycoprotein 1 (PSBG1) to human chromosome 19q13.1

Niemann, Susanne; Schonk, D.; Dijk, Peter van; Wieringa, B.; Grzeschik, K.-H.; Bartels, Iris

doi:10.1159/000132851

Cited by 8 publications

(9 citation statements)

References 3 publications

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“…SNRPA therefore maps to the same segment where pPM6.7 (D19S18) and OL5 (DNF11) are localized (for further details, see Schonk et al, 1989). The hybridization patterns of SNRP70, APS, and KLKI showed them to be absent in DN As from cell hybrids 20KP3542-1-4 and 908K1 and its derivatives.…”

Section: Resultsmentioning

confidence: 93%

“…The con struction, chromosome composition. and specific chromosome 19 content of all other hybrids have been described in detail by Schonk et al (1989).…”

Section: Cell Hybridsmentioning

confidence: 99%

“…DNA fragments were excised front the plasmid vectors with the appropriate enzymes and isolated on lowtemperature agarose gels (Bio-Rad). DNA labeling, hybridization, and au toradiography were performed as described previously (Schonk et al, 1989).…”

Section: Souillent Blot Analysis and Dna Probesmentioning

confidence: 99%

“…The endeavor to locate the myotonic dystrophy locus (DM) has significantly contributed to our overall knowledge about the physical and genetic organization of this chromosome and, in par ticular, its long arm (Le Beau et al, 1989;Schonk et al, 1989).…”

mentioning

confidence: 99%

“…Here we describe the use of a somatic cell hybrid panel with distinct der( 19q) segments (Schonk et al, 1989) for mapping seven genes on chromosome 19 that could serve as possibly interesting targets in relation to the DM locus. All but one of the seven genes belong to larger gene clusters or gene families.…”

mentioning

confidence: 99%

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Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region

Schonk

Dijk

Riegmann

et al. 1990

Cytogenet Genome Res

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Hybridization studies using a panel of somatic cell hybrids with subchromosomal segments of 19q have localized the genes encoding hormone-sensitive lipase (LIPE), carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A (SNRPA) to various regions of 19q13.1; the cellular receptor for poliovirus sensitivity (PVS) to 19ql3.2; and the genes coding for prostate-specific antigen (APS), human pancreatic kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD poly-peptide (SNRP70) to 19q 13.3 →qter. Our results exclude several of these genes from being seriously considered as a candidate for the myotonic dystrophy gene on 19q.

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Section: Resultsmentioning

confidence: 93%

“…The con struction, chromosome composition. and specific chromosome 19 content of all other hybrids have been described in detail by Schonk et al (1989).…”

Section: Cell Hybridsmentioning

confidence: 99%

Section: Souillent Blot Analysis and Dna Probesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region

Schonk

Dijk

Riegmann

et al. 1990

Cytogenet Genome Res

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Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

Thompson

Fritz

Zimmermann

1991

Clinical Laboratory Analysis

558

389

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The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons. In humans it is clustered on the long arm of chromosome 19 and consists of approximately 20 genes. The CEA subgroup genes code for CEA and its classical crossreacting antigens, which are mainly membrane-bound, whereas the other subgroup genes encode the pregnancy-specific glycoproteins (PSG), which are secreted. Splice variants of individual genes and differential post-translational modifications of the resulting proteins, e.g., by glycosylation, indicate a high complexity in the number of putative CEA-related molecules. So far, only a limited number of CEArelated antigens in humans have been unequivocally assigned to a specific gene.Rodent CEA-related genes reveal a high sequence divergence and, in part, a completely different domain organization than the human CEA gene family, making it difficult to determine individual gene counterparts. However, rodent CEA-related genes can be assigned to human subgroups based on similarity of expression patterns, which is characteristic for the subgroups. Various functions have been determined for members of the CEA subgroup in vitro, including cell adhesion, bacterial binding, an accessory role for collagen binding or ecto-ATPases activity.Based on all that is known so far on its biology, the clinical outlook for the CEA family has been reassessed.

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Pregnancy specific ?1-glycoprotein in human intestine

Shupert

Chan

1993

Mol Cell Biochem

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Pregnancy-specific beta 1-glycoprotein (PSG) transcripts have been identified in a number of placental and non-placental tissues. Using a placental PSG cDNA probe to screen a normal human intestinal cDNA library we have isolated 22 hybridizing clones. These clones could be divided into four groups. Nucleotide sequence analysis showed that one group of clones correspond to functional and another group correspond to non-functional PSG cDNAs. The other two groups are homologous to the nonspecific cross-reacting antigen (NCA) and biliary glycoprotein (BGP), both of which are members of the carcinoembryonic antigen (CEA) family. Thus, PSG, NCA and BGP are co-expressed in normal human intestine. RNA and immunoblot analysis, along with polymerase chain reaction amplification further confirm the expression of PSG in human intestinal tissue.

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Regional localization of the gene encoding pregnancy specific beta-1-glycoprotein 1 (PSBG1) to human chromosome 19q13.1

Cited by 8 publications

References 3 publications

Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region

Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

Pregnancy specific ?1-glycoprotein in human intestine

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