Regional lung function in patients with bronchial asthma

Heckscher, T; Bass, Harry; Oriol, A; Rose, B.; Anthonisen, Nicholas R.; Bates, David V.

doi:10.1172/jci105796

Cited by 61 publications

(21 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 there is inflammatory cell infiltration and fibrosis around the small airways, and the airways appear smaller than normal. These abnormalities occurring in subjects with advanced peripheral airway obstruction have been described previously (17).…”

Section: Resultsmentioning

confidence: 55%

Frequency dependence of compliance as a test for obstruction in the small airways

Woolcock¹,

Vincent²,

Macklem³

1969

J. Clin. Invest.

368

143

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 55%

Frequency dependence of compliance as a test for obstruction in the small airways

Woolcock¹,

Vincent²,

Macklem³

1969

J. Clin. Invest.

368

143

View full text Add to dashboard Cite

“…have demonstrated that hypoxemia can result from the maldistribution of ventilation due to narrowing of small (<2 mm) airways, an obstruction which is not detected by standard physiologic studies (20,21). In light of these newer concepts of small airways disease, the present study was designed to: (a) evaluate the morphology of small airways in IPF; (b) determine if patients with IPF have physiologic alterations consistent with small airways disease; and (c) attempt to correlate these morphologic and physiologic findings.…”

Section: Introductionmentioning

confidence: 99%

Small Airways in Idiopathic Pulmonary Fibrosis

Fulmer¹,

Roberts²,

Gál³

et al. 1977

J. Clin. Invest.

169

View full text Add to dashboard Cite

A B S T R A C T 18 patients with idiopathic pulmonary fibrosis were studied to determine if they had morphologic evidence of small airways disease and if physiologic testing could predict morphologic findings. In the presence of normal airway function by standard physiologic studies (forced expiratory volume in 1 s/forced vital capacity and airway resistance by plethysmography), dynamic compliance, maximum expiratory flow-volume curves, and maximum flowstatic recoil curves were measured to detect physiologic alterations consistent with small airways abnormalities. These physiologic data were then compared with estimates of small airways diameter made in lung biopsy specimens.94% (17 of 18) of the patients had peribronchiolar fibrosis or peribronchiolar inflammation or bronchiolitis. 67% (12 of 18) had an overall estimate of small airways diameter of "narrowed," whereas 33% (6 of 18) had airways that overall were "not narrowed." 59% (10 of 17) had frequency-dependent dynamic compliance, 50% (9 of 18) had abnormal maximum expiratory flow-volume curves, and 39% (7 of 18) had abnormal maximum flow-static recoil curves. Comparisons between morphologic and physiologic data revealed a significant correlation between the results of dynamic compliance and the overall estimate of small airways diameter (P = 0.001), and the results of maximum flow-volume curves and the overall estimate of small airways diameter (P = 0.009); there was no significant correlation between the results of maximum flow-static recoil curves and the overall estimate of small airways diameter (P = 0.1).The results of this study suggest that: (a) idiopathic pulmonary fibrosis is a disease of small airways as

show abstract

“…In asthma, the occurrence of regional hypoventilation that can in some instances be very severe, suggesting complete closure of the airways, has long been known from ventilation imaging [11]. In fact, such severe regional heterogeneity is a common occurrence in routine ventilation/perfusion (V/Q) imaging in nuclear medicine for the diagnosis of suspected pulmonary embolism.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Tomographic Imaging of Small Airways

King

2012

Respiration

View full text Add to dashboard Cite

Three-dimensional lung imaging has become a routine investigation in clinical medicine. The clinical needs have driven the development of tomographic imaging, as much as the research into better imaging itself has driven some of the improvements in imaging. There has been a steady stream of publications in which tomographic imaging has been used to measure small airway structure and function in obstructive airway diseases. These data provide unique insights and information on pulmonary physiology because they provide direct measurements of the airways, rather than global information from lung function, and they provide topographical information, i.e. spatial distribution. Their utility is magnified when combined with other information such as lung function. In this article, the application of topographic imaging in relation to small airway function is discussed.

show abstract

Regional lung function in patients with bronchial asthma

Cited by 61 publications

References 13 publications

Frequency dependence of compliance as a test for obstruction in the small airways

Frequency dependence of compliance as a test for obstruction in the small airways

Small Airways in Idiopathic Pulmonary Fibrosis

Tomographic Imaging of Small Airways

Contact Info

Product

Resources

About