Regional maps of rib cortical bone thickness and cross‐sectional geometry

Holcombe, Sven A.; Kang, Yun‐Seok; Derstine, Brian A.; Wang, Stewart C.; Agnew, Amanda M.

doi:10.1111/joa.13045

Cited by 19 publications

(30 citation statements)

References 26 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previous work, CBM has achieved sub-pixel accuracy in bone thickness estimations (Treece et al 2010), and specifically for rib cortices, an accuracy (mean thickness error) and precision (standard deviation error) of À0.03 ± 0.17 mm was obtained using CT images of 0.373 mm/pixel. The current study uses CT voxel sizes of 0.146 Â 0.146 Â 0.625 mm, where the CBM accuracy ± precision have been shown to be À0.013 ± 0.17 mm (Holcombe et al 2019). Nevertheless, with fractures likely occurring near vulnerable bone regions with very small cortices in the order of 0.1-0.2 mm, even this sub-millimeter error can potentially influence fracture outcome.…”

Section: Discussionmentioning

confidence: 99%

Detailed subject-specific FE rib modeling for fracture prediction

Iraeus

Lundin²,

Storm³

et al. 2019

Traffic Injury Prevention

Self Cite

View full text Add to dashboard Cite

Objective: The current state of the art human body models (HBMs) underpredict the number of fractured ribs. Also, it has not been shown that the models can predict the fracture locations. Efforts have been made to create subject specific rib models for fracture prediction, with mixed results. The aim of this study is to evaluate if subject-specific finite element (FE) rib models, based on state-of-the-art clinical CT data combined with subject-specific material data, can predict rib stiffness and fracture location in anterior-posterior rib bending. Method: High resolution clinical CT data was used to generate detailed subject-specific geometry for twelve FE models of the sixth rib. The cortical bone periosteal and endosteal surfaces were estimated based on a previously calibrated cortical bone mapping algorithm. The cortical and the trabecular bone were modeled using a hexa-block algorithm. The isotropic material model for the cortical bone in each rib model was assigned subject-specific material data based on tension coupon tests. Two different modeling strategies were used for the trabecular bone. The capability of the FE model to predict fracture location was carried out by modeling physical dynamic anterior-posterior rib bending tests. The rib model predictions were directly compared to the results from the tests. The predicted force-displacement time history, strain measurements at four locations, and rotation of the rib ends were compared to the results from the physical tests by means of CORA analysis. Rib fracture location in the FE model was estimated as the position for the element with the highest first principle strain at the time corresponding to rib fracture in the physical test. Results: Seven out of the twelve rib models predicted the fracture locations (at least for one of the trabecular modeling strategies) and had a force-displacement CORA score above 0.65. The other five rib models, had either a poor force-displacement CORA response or a poor fracture location prediction. It was observed that the stress-strain response for the coupon test for these five ribs showed significantly lower Young's modulus, yield stress, and elongation at fracture compared to the other seven ribs. Conclusion: This study indicates that rib fracture location can be predicted for subject specific rib models based on high resolution CT, when loaded in anterior-posterior bending, as long as the rib's cortical cortex is of sufficient thickness and has limited porosity. This study provides guidelines for further enhancements of rib modeling for fracture location prediction with HBMs.

show abstract

Section: Discussionmentioning

confidence: 99%

Detailed subject-specific FE rib modeling for fracture prediction

Iraeus

Lundin²,

Storm³

et al. 2019

Traffic Injury Prevention

Self Cite

View full text Add to dashboard Cite

show abstract

“…Rib bone properties including cortex thickness play a key role in fracture events and show large inter-subject variation as well as regional variation across the rib cage (Agnew et al, 2018;Kemper et al, 2005Kemper et al, , 2007Murach et al, 2017). Rib cortical thickness has been measured to span approximately 0.1-2.6 mm (Agnew et al, 2018;Choi & Kwak, 2011;Holcombe, Kang, Derstine, et al, 2019;Mohr et al, 2007), but these data are limited to individual rib levels or sites, or have been aggregated across broad regions containing wide ranges of variation. To date, thickness measurements across multiple levels and in sufficient detail for direct application to HBMs has not yet been expounded in the literature.…”

Section: Introductionmentioning

confidence: 99%

Rib cortical bone thickness variation in adults by age and sex

Holcombe

Derstine

2022

Journal of Anatomy

Self Cite

View full text Add to dashboard Cite

Rib fractures are a common and serious outcome of blunt thoracic trauma and their likelihood is greater in older individuals. Osteoporotic bone loss is a well-documented aging phenomenon with sex-specific characteristics, but within rib bones, neither baseline maps of regional thickness nor the rates of bone thinning with age have been quantified across whole ribs. This study presents such data from 4014 ribs of 240 adult subjects aged 20-90. A validated cortical bone mapping technique was applied to clinical computed tomography scans to obtain local rib cortical bone thickness measurements over the surfaces of ribs 2 through 11. Regression models to age and sex gave rates of cortex thinning in local zones and aggregated across whole ribs. The statistical parametric mapping provided these relationships regionally as a function of rib surface location. All models showed significant reductions in bone thickness with age (p < 0.01). Average whole-rib thinning occurred at between 0.011 to 0.032 mm/ decade (males) and 0.035 to 0.043 mm/decade (females), with sex and age accounting for up to 37% of population variability (R 2 ). Rates of thinning differed regionally and by rib, with the highest bone loss of up to 0.074 mm/decade occurring in mid-rib cutaneous and superior regions of ribs 2-6. Rates were consistently higher in females than males (significantly so across whole ribs but not all local regions) and were more pronounced in cutaneous, superior, and inferior rib aspects (average 0.025 mm/decade difference in ribs 4-8) compared to pleural aspects which had the thickest cortices but saw only minor differences in thinning rates by sex (0.045 mm/decade for females and 0.040 mm/decade for males). Regional analysis showed male and female bone thickness differences that were not statistically significant at 20 years of age (p > 0.05 across practically all regions) but subsequent cortex thinning meant that substantial pleural and cutaneous regions were thinner (p < 0.05) in females than males by 55 years of age. The techniques and results from this study can be applied to assess rib bone content loss in clinical settings across wide populations. Additionally, average cortex thickness results can be mapped directly to finite element models of the thorax, and regression results are used to modify such models to represent the ribs of men and women across their full adult lifespan.

show abstract

“…Половой диморфизм затрагивает также отдельные компоненты грудной клетки [26,27]. Имеются исследования, подтверждающие наличие полового диморфизма диафрагмы [2].…”

Section: направления и результаты научных исследованийunclassified

“…S.A. Holombe и соавт. (2019) доказали, что ребра у мужчин имеют большую толщину и площадь поперечного сечения, чем женские [26]. A.M. Kubicka и J. Piontek (2016) выявили, что определение размеров первого ребра позволяет определить пол пациента с вероятностью до 80% [27].…”

Section: направления и результаты научных исследованийunclassified

“…Интеграция антропометрических показателей находит отражение в соматотипировании. В современной литературе описано более 100 конституциональных и соматотипологических схем, которые базируются на самых разнообразных системах признаков [26,33,34]. За последнее время в литературе появился ряд исследований, посвященных соматотипированию различных групп населения и поиску связи между соматотипом и анатомическим строением отдельных органов [7,12,18,31,35].…”

Section: направления и результаты научных исследованийunclassified

See 1 more Smart Citation

Modern concepts of constitutional and X-ray anatomy of the chest in adolescents and adults

Луцай

Shekhtman

Александр³

et al. 2021

Science and Innovations in Medicine

View full text Add to dashboard Cite

The review presents the analysis of domestic and foreign literature, selecting the available scientific data on the features of constitutional and X-ray anatomy of the chest in adolescents and adults. The size and shape of the chest depends on age, sex and anthropometric parameters: height, body mass index, and also the presence of concomitant pathology. These patterns are characteristic of individual anatomical structures of the chest: sternum, ribs, spine and diaphragm. The study of constitutional anatomy is necessary for the development of morphological foundations for the interpretation of the results of intravital imaging of the chest and organs, justification of various methods of surgical access to the organ and structures of the chest and chest cavity.

show abstract

Regional maps of rib cortical bone thickness and cross‐sectional geometry

Cited by 19 publications

References 26 publications

Detailed subject-specific FE rib modeling for fracture prediction

Detailed subject-specific FE rib modeling for fracture prediction

Rib cortical bone thickness variation in adults by age and sex

Modern concepts of constitutional and X-ray anatomy of the chest in adolescents and adults

Contact Info

Product

Resources

About