2024
DOI: 10.1111/andr.13630
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Regional modulation of toll‐like receptor signaling pathway genes in acute epididymitis in mice

Alexandre D. Andrade,
Priscila G. C. Almeida,
Noemia A. P. Mariani
et al.

Abstract: BackgroundRegion‐specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll‐like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region‐specific inflammatory responses to bacterial‐derived TLR agonists, such as lipopolysaccharide (LPS; TLR4 agonist) and lipoteichoic acid (LTA; TLR2/TLR6 agonist), suggesting that TLR‐associated … Show more

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