Regional odontodysplasia: An analysis of 161 cases from 1953 to 2017

Abstract

Background and objectiveRegional odontodysplasia (RO) is a localized developmental anomaly involving both dentitions. The characteristic clinical findings are soft discolored several contiguous teeth with atypical morphology associated with swelling or abscess formation. Radiographic images of the involved teeth show a ghost-like appearance because enamel and dentin are hypoplastic and hypocalcified. Although RO is known for more than seven decades, the literature on RO is mostly limited to case reports.The objective of this investigation was to provide an updated review of the literature with regards to clinical presentation and epidemiology of RO. Because of its rarity, retrospective analysis of the published reports across the world is considered one of the most appropriate available methods to analyze epidemiological and clinical data of RO. This review was reported and conducted according to the PRISMA guidelines.ResultsBetween 1953 and 2017, 161 cases were reported in literatures written in English. At the time of diagnosis, the age of the patients ranged between 1 and 25 years. There was slight female predilection with a ratio of 1.37: 1. When examined collectively, the maxilla was commonly affected compared to the mandible. RO occurred in both dentitions in 75 reported cases. While it affects the deciduous teeth alone in 19.3% and the permanent teeth in 34.2% of the cases. Failure of tooth eruption was the most common presenting finding (41.6%) followed by swelling of the affected area (32.3%).ConclusionAlthough RO was first described almost 80 years ago and the total subsequent case reports were over 160 cases, there is no consensus on its pathogenesis and how it should be treated. The descriptive nature of the examined case reports reveals the limited information on this condition. Further experimental and genetic studies are needed.

Regional Odontodysplasia: A Systematic Review of Case Reports

“…However, the collected data shows that there is no significant sex predilection of regional odontodysplasia. On the contrary, other literature gives ratios as high as 1.37:1, 1.4:1 and even 1.7:1 of female to male cases, which shows a big difference from our results presented in this review (1.03:1) [18][19][20]. The possible explanation for this disparity can be a high number of new case reports taken into account in this article compared to older works.…”

Regional odontodysplasia on the left side of the mandible: report of an unusual case

“…A recent systematic review of published RO cases by Nijakowski et al [4] reported no significant gender predilection. Conversely, other literature showed that women might be slightly more affected than men [3].…”

“…However, it was found that this anomaly has no ethnic tendency. The mandible is less frequently affected than the maxilla [1,3]. A recent systematic review of published RO cases by Nijakowski et al [4] reported no significant gender predilection.…”

Regional odontodysplasia diagnosed and treated via multidisciplinary approach: a case report

“…It often occurs in children and adolescents and with a recorded peak at ages 2-5 and 8-12 years. In most cases, both dentitions are involved, and the maxilla is more commonly affected [20]. The ratio of males to females is reported to be 1:1.37 [2].…”