Regional reward differences within the ventral pallidum are revealed by microinjections of a mu opiate receptor agonist

Johnson, Patricia I.; Stellar, James R.; Paul, A.David

doi:10.1016/0028-3908(93)90025-x

Cited by 76 publications

(56 citation statements)

References 28 publications

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“…In any case, it denotes that the stimulation is more rewarding when applied to the caudal than the rostral VP. This finding supports the idea that the VP is not homogeneous in regard to the reward functions [ 12]. For example, Robtedo and Koob [25] found that two discrete VP-NAC projection areas differentially mediate cocaine self-administration in the rat.…”

Section: Discussionsupporting

confidence: 79%

“…For example, Robtedo and Koob [25] found that two discrete VP-NAC projection areas differentially mediate cocaine self-administration in the rat. Furthermore, as mentioned in the introduction, Johnson et al [12] reported that DAMGO increased or decreased lateral hypothalamic self-stimulation when injected into the caudal or rostral VP, respectively. Based on this finding, they have suggested the presence of heterogeneity in VP reward functions.…”

Section: Discussionmentioning

confidence: 92%

“…For instance, McAlonan et al [17], have used the conditioned place preference paradigm and postulated that the rostral rather than the caudal part of the ventral pallidum is more heavily involved in reward. Also, Johnson, Stellar and Paul [12], have shown that microinjection ofmu-opiate receptor agonist into the caudal or rostral pallidum differentially modulates lateral hypothalamic self-stimulation. These results taken together make the study of the role of the ventral pallidum in reward very challenging.…”

Section: Introductionmentioning

confidence: 99%

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Ventral pallidum self-stimulation: a moveable electrode mapping study

Panagis

Miliaressis

Anagnostakis

et al. 1995

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ventral pallidum self-stimulation: a moveable electrode mapping study

Panagis

Miliaressis

Anagnostakis

et al. 1995

Behavioural Brain Research

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“…These population and temporal firing mechanisms would allow liking, wanting, and prediction signals to be told apart within ventral striatopallidal circuits during natural appetite, drug intoxication or withdrawal, or stress states known to elevate reward measures (1,2,4,22,25,27,30,31,46,76). We suggest that these VP neuronal signals for reward components could be related to reports of activity in human posterior VP positively correlated with pleasant food images (17) and mechanisms by which opioid and related stimulation in a VP hotspot can modulate the hedonic impact of sensory rewards (33,36,77). Conversely, one could speculate that impairment of hedonic signals in NAc-VP pathways could contribute to clinical manifestations of anhedonia or incentive motivation impairment in depression and related disorders (78) or to dysphoria after lesions encroaching on the VP hotspot (79)(80)(81).…”

Section: Reward Component Separation By Population Segregation and Fimentioning

confidence: 90%

Disentangling pleasure from incentive salience and learning signals in brain reward circuitry

Smith

Berridge

Aldridge

2011

Proc. Natl. Acad. Sci. U.S.A.

354

330

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Multiple signals for reward-hedonic impact, motivation, and learned associative prediction-are funneled through brain mesocorticolimbic circuits involving the nucleus accumbens and ventral pallidum. Here, we show how the hedonic "liking" and motivation "wanting" signals for a sweet reward are distinctly modulated and tracked in this circuit separately from signals for Pavlovian predictions (learning). Animals first learned to associate a fixed sequence of Pavlovian cues with sucrose reward. Subsequent intraaccumbens microinjections of an opioid-stimulating drug increased the hedonic liking impact of sucrose in behavior and firing signals of ventral pallidum neurons, and likewise, they increased incentive salience signals in firing to the reward-proximal incentive cue (but did not alter firing signals to the learned prediction value of a reward-distal cue). Microinjection of a dopamine-stimulating drug instead enhanced only the motivation component but did not alter hedonic impact or learned prediction signals. Different dedicated neuronal subpopulations in the ventral pallidum tracked signal enhancements for hedonic impact vs. incentive salience, and a faster firing pattern also distinguished incentive signals from slower hedonic signals, even for a third overlapping population. These results reveal separate neural representations of wanting, liking, and prediction components of the same reward within the nucleus accumbens to ventral pallidum segment of mesocorticolimbic circuitry.addiction | obesity | limbic | reinforcement | striatum

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“…19 The VP contributes to the regulation of drug selfadministration, 21 drug 17,20 and sucrose-induced 27 place preference, and modulates hypothalamic selfstimulation (SS). 23,24 Furthermore, a recent study using moveable electrodes 30 showed that electrical activation of nearly all VP sites maintains vigorous SS. Characterization of VP SS neurons using the double-pulse stimulation technique 32 showed that post-stimulation recovery time differs substantially between VP SS sites: For some sites, partial neural recovery was apparent as shortly as 0.6 ms following the first conditioning pulse and was completed 1 ms later whereas, for other sites recovery started later and failed to get completed before 5 ms. Short and long refractory period sites were rather dispersed than topographically arranged within the VP.…”

mentioning

confidence: 99%