Regional scattering of primate subplate

Molnár, Zoltán; Hoerder‐Suabedissen, Anna

doi:10.1073/pnas.1611194113

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…In terms of the diffusion signal, this strongly aligned microstructure of the radial glia is represented in our results by a higher tissue fraction in the transient compartments containing the most migratory cells (such as the VZ, IZ) ( Kostović and Judas, 2010 ). Conversely, we observe the lowest tissue fraction in the early prenatal SP, which predominantly contains hydrophilic extracellular matrix, as demonstrated by rodent and non-human primate studies ( Allendoerfer and Shatz, 1994 ; Miller et al, 2014 ; Molnár and Hoerder-Suabedissen, 2016 ).…”

Section: Discussionsupporting

confidence: 75%

Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain

Wilson

Pietsch

Cordero‐Grande

et al. 2023

eLife

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The development of connectivity between the thalamus and maturing cortex is a fundamental process in the second half of human gestation, establishing the neural circuits that are the basis for several important brain functions. In this study, we acquired high-resolution in utero diffusion MRI from 140 fetuses as part of the Developing Human Connectome Project, to examine the emergence of thalamocortical white matter over the second to third trimester. We delineate developing thalamocortical pathways and parcellate the fetal thalamus according to its cortical connectivity using diffusion tractography. We then quantify microstructural tissue components along the tracts in fetal compartments that are critical substrates for white matter maturation, such as the subplate and intermediate zone. We identify patterns of change in the diffusion metrics that reflect critical neurobiological transitions occurring in the second to third trimester, such as the disassembly of radial glial scaffolding and the lamination of the cortical plate. These maturational trajectories of MR signal in transient fetal compartments provide a normative reference to complement histological knowledge, facilitating future studies to establish how developmental disruptions in these regions contribute to pathophysiology.

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Section: Discussionsupporting

confidence: 75%

Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain

Wilson

Pietsch

Cordero‐Grande

et al. 2023

eLife

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“…The location in the deep WM partially addresses the concern that these neurons might be corticostriatal neurons displaced from Layer 6 (as does the fact that corticostriatal neurons are more typically situated in Layer 5). Homology with WMNs in primates continues under discussion (Meyer et al, ; Molnár & Hoerder‐Suabedissen, ; Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

Projections to the putamen from neurons located in the white matter and the claustrum in the macaque

Borra

Luppino

Gerbella

et al. 2019

J of Comparative Neurology

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Continuing investigations of corticostriatal connections in rodents emphasize an intricate architecture where striatal projections originate from different combinations of cortical layers, include an inhibitory component, and form terminal arborizations which are cell-type dependent, extensive, or compact. Here, we report that in macaque monkeys, deep and superficial cortical white matter neurons (WMNs), periclaustral WMNs, and the claustrum proper project to the putamen. WMNs retrogradely labeled by injections in the putamen (four injections in three macaques) were widely distributed, up to 10 mm antero-posterior from the injection site, mainly dorsal to the putamen in the external capsule, and below the premotor cortex. Striatally projecting labeled WMNs (WMNsST) were heterogeneous in size and shape, including a small GABAergic component. We compared the number of WMNsST with labeled claustral and cortical neurons and also estimated their proportion in relation to total WMNs. Since some WMNsST were located adjoining the claustrum, we wanted to compare results for density and distribution of striatally projecting claustral neurons (ClaST). ClaST neurons were morphologically heterogeneous and mainly located in the dorsal and anterior claustrum, in regions known to project to frontal, motor, and cingulate cortical areas. The ratio of ClaST to WMNsST was about 4:1 averaged across the four injections. These results provide new specifics on the connectional networks of WMNs in nonhuman primates, and delineate additional loops in the corticostriatal architecture, consisting of interconnections across cortex, claustralstriatal and striatally projecting WMNs.

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“…This section draws heavily upon many excellent reviews (Nadarajah and Parnavelas, 2002 ; López-Bendito and Molnár, 2003 ; Cheung et al, 2007 ; Molnár et al, 2012 ; Tabata et al, 2012 ; Evsyukova et al, 2013 ; Tan and Shi, 2013 ; Sekine et al, 2014 ; Hoerder-Suabedissen and Molnár, 2015 ; Kawauchi, 2015 ; Molnár and Hoerder-Suabedissen, 2016 ). (Montiel et al, 2016 , Figure 1; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832283/figure/cne23871-fig-0001/ ).…”

Section: Principal Cellsmentioning

confidence: 99%

Cornu Ammonis Regions–Antecedents of Cortical Layers?

Mercer

Thomson

2017

Front. Neuroanat.

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Studying neocortex and hippocampus in parallel, we are struck by the similarities. All three to four layered allocortices and the six layered mammalian neocortex arise in the pallium. All receive and integrate multiple cortical and subcortical inputs, provide multiple outputs and include an array of neuronal classes. During development, each cell positions itself to sample appropriate local and distant inputs and to innervate appropriate targets. Simpler cortices had already solved the need to transform multiple coincident inputs into serviceable outputs before neocortex appeared in mammals. Why then do phylogenetically more recent cortices need multiple pyramidal cell layers? A simple answer is that more neurones can compute more complex functions. The dentate gyrus and hippocampal CA regions—which might be seen as hippocampal antecedents of neocortical layers—lie side by side, albeit around a tight bend. Were the millions of cells of rat neocortex arranged in like fashion, the surface area of the CA pyramidal cell layers would be some 40 times larger. Even if evolution had managed to fold this immense sheet into the space available, the distances between neurones that needed to be synaptically connected would be huge and to maintain the speed of information transfer, massive, myelinated fiber tracts would be needed. How much more practical to stack the “cells that fire and wire together” into narrow columns, while retaining the mechanisms underlying the extraordinary precision with which circuits form. This demonstrably efficient arrangement presents us with challenges, however, not the least being to categorize the baffling array of neuronal subtypes in each of five “pyramidal layers.” If we imagine the puzzle posed by this bewildering jumble of apical dendrites, basal dendrites and axons, from many different pyramidal and interneuronal classes, that is encountered by a late-arriving interneurone insinuating itself into a functional circuit, we can perhaps begin to understand why definitive classification, covering every aspect of each neurone's structure and function, is such a challenge. Here, we summarize and compare the development of these two cortices, the properties of their neurones, the circuits they form and the ordered, unidirectional flow of information from one hippocampal region, or one neocortical layer, to another.

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Regional scattering of primate subplate

Cited by 8 publications

References 24 publications

Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain

Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain

Projections to the putamen from neurons located in the white matter and the claustrum in the macaque

Cornu Ammonis Regions–Antecedents of Cortical Layers?

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