Regional Specificity of GABAergic Regulation of Cross-Modal Plasticity in Mouse Visual Cortex after Unilateral Enucleation

Nys, Julie; Smolders, Katrien; Laramée, Marie-Eve; Hofman, Isabel Juliana F; Hu, Tjing-Tjing; Arckens, Lutgarde

doi:10.1523/jneurosci.3808-14.2015

Cited by 16 publications

(42 citation statements)

References 120 publications

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“…Although our choice was made toward this specific dataset because of our molecular enucleation model and of our previous results (Van Brussel et al, 2011; Nys et al, 2014, 2015), the method is certainly not limited to brain tissue, coronal sections or to in situ hybridization data. First, any tissue or organ (kidney, heart, brain…) of any species (animal or plant) is suitable within the limitations of the applied imaging technique.…”

Section: Discussionmentioning

confidence: 99%

“…Cresyl violet stainings provide sufficient information to delineate the primary visual cortex (V1), lateral extrastriate cortex (V2L), medio-lateral extrastriate cortex (V2ML) and medio-medial extrastriate cortex (V2MM) based on the cytoarchitecture as described in detail previously (Caviness, 1975; van Brussel et al, 2009; Van Brussel et al, 2011; Nys et al, 2014, 2015; Smolders et al, 2015) and comparisons were made with the stereotaxic mouse brain atlas (Paxinos and Franklin, 2013). The border annotations for each section were superimposed onto the corresponding autoradiographic image with Adobe Photoshop CS6 before being imported in Matlab (Figure 1A) to aid interpretation of areal borders in the created top views.…”

Section: Methodsmentioning

confidence: 99%

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A Tool for Brain-Wide Quantitative Analysis of Molecular Data upon Projection into a Planar View of Choice

et al. 2017

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Several techniques, allowing the reconstruction and visualization of functional, anatomical or molecular information from tissue and organ slices, have been developed over the years. Yet none allow direct comparison without reprocessing the same slices. Alternative methods using publicly available reference maps like the Allen Brain Atlas lack flexibility with respect to age and species. We propose a new approach to reconstruct a segmented region of interest from serial slices by projecting the optical density values representing a given molecular signal to a plane of view of choice, and to generalize the results into a reference map, which is built from the individual maps of all animals under study. Furthermore, to allow quantitative comparison between experimental conditions, a non-parametric pseudo t-test has been implemented. This new mapping tool was applied, optimized and validated making use of an in situ hybridization dataset that represents the spatiotemporal expression changes for the neuronal activity reporter gene zif268, in relation to cortical plasticity induced by monocular enucleation, covering the entire mouse visual cortex. The created top view maps of the mouse brain allow precisely delineating and interpreting 11 extrastriate areas surrounding mouse V1. As such, and because of the opportunity to create a planar projection of choice, these molecular maps can in the future easily be compared with functional or physiological imaging maps created with other techniques such as Ca2+, flavoprotein and optical imaging.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Tool for Brain-Wide Quantitative Analysis of Molecular Data upon Projection into a Planar View of Choice

et al. 2017

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“…In situ hybridization was performed as previously described (Arckens et al, 1995;Nys et al, 2015). Series of coronal brain sections between Bregma levels À2.70 and À4.84 were analysed to examine the exact anatomical location and the spatial extent of neuronal activity changes throughout the complete visual cortex as well as subcortical retinal targets, by measuring changes in the expression of the IEG zif268.…”

Section: In Situ Hybridizationmentioning

confidence: 99%

“…Cresyl violet provides sufficient information to delineate the different areas analysed, including primary visual cortex (V1), lateral extrastriate cortex (V2L), medial extrastriate cortex (V2M), rostromedial areas (RM), and agranular and granular retrosplenial cortex (RSA/RSG) ( Fig. 2A) as described in detail previously (Van Der Gucht et al, 2007;Van Brussel et al, 2009, 2011Nys et al, 2014Nys et al, , 2015. All topographic denominations were adopted from these papers.…”

Section: Histological Verification Of the Position Of Lpzs In Differementioning

confidence: 99%

Retinal lesions induce fast intrinsic cortical plasticity in adult mouse visual system

Smolders

Vreysen

Laramée

et al. 2016

Eur J of Neuroscience

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Neuronal activity plays an important role in the development and structural-functional maintenance of the brain as well as in its life-long plastic response to changes in sensory stimulation. We characterized the impact of unilateral 15°laser lesions in the temporal lower visual field of the retina, on visually driven neuronal activity in the afferent visual pathway of adult mice using in situ hybridization for the activity reporter gene zif268. In the first days post-lesion, we detected a discrete zone of reduced zif268 expression in the contralateral hemisphere, spanning the border between the monocular segment of the primary visual cortex (V1) with extrastriate visual area V2M. We could not detect a clear lesion projection zone (LPZ) in areas lateral to V1 whereas medial to V2M, agranular and granular retrosplenial cortex showed decreased zif268 levels over their full extent. All affected areas displayed a return to normal zif268 levels, and this was faster in higher order visual areas than in V1. The lesion did, however, induce a permanent LPZ in the retinorecipient layers of the superior colliculus. We identified a retinotopy-based intrinsic capacity of adult mouse visual cortex to recover from restricted vision loss, with recovery speed reflecting the areal cortical magnification factor. Our observations predict incomplete visual field representations for areas lateral to V1 vs. lack of retinotopic organization for areas medial to V2M. The validation of this mouse model paves the way for future interrogations of cortical region-and cell-type-specific contributions to functional recovery, up to microcircuit level.

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“…In particular, it has been well established in the case of the human V1, which is inherently multisensory [23]. In adult mice, vision loss through one eye leads whiskers to become a dominant nonvisual input source which attains extensive visual cortical reactivation [24]. In blind individuals, when visual inputs are absent, occipital ("visual") brain regions respond to sound and spoken language [25].…”

Section: Classical Vs Current Viewmentioning

confidence: 99%

A Symmetric Approach Elucidates Multisensory Information Integration

Tozzi

Peters

2016

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Recent advances in neuronal multisensory integration suggest that the five senses do not exist in isolation of each other. Perception, cognition and action are integrated at very early levels of central processing, in a densely-coupled system equipped with multisensory interactions occurring at all temporal and spatial stages. In such a novel framework, a concept from the far-flung branch of topology, namely the Borsuk-Ulam theorem, comes into play. The theorem states that when two opposite points on a sphere are projected onto a circumference, they give rise to a single point containing their matching description. Here we show that the theorem applies also to multisensory integration: two environmental stimuli from different sensory modalities display similar features when mapped into cortical neurons. Topological tools not only shed new light on questions concerning the functional architecture of mind and the nature of mental states, but also provide an empirically assessable methodology. We argue that the Borsuk-Ulam theorem is a general principle underlying nervous multisensory integration, resulting in a framework that has the potential to be operationalized.Keywords: multimodal; heteromodal; integration; neuron; brain; Borsuk-Ulam theorem; antipodal "A color is a physical object when we consider its dependence upon its luminous source; regarding, however, its dependence upon the retina, it becomes a psychological object, a sensation. Not the subject, but the direction of our investigation, is different in the two domains" (Mach 1885).Current advances in human neurosciences shed new light on questions concerning the status of the mental and its relation to the physical. Multisensory neurons (we will also term them "heteromodal" or "multimodal") receiving convergent inputs from multiple sensory modalities (independent sources of information called "cues") integrate information from the five different senses [1]. When cues are available, combining them facilitates the detection of salient events and reduces perceptual uncertainty, in order to improve reactions to immediate dangers and to rapidly varying events [2]. Multisensory neurons are able as well to carry out complex brain activities, such as object categorization [3]. Heteromodal integration displays complicated temporal patterns: absent in the superior colliculus of newborn's brain, it arises in the earlier weeks/months of postnatal life [4,5]. As time goes on, neurons develop their capacity to engage in multisensory integration, which determines whether stimuli are to be integrated or treated as independent events. Multisensory integration's development is due to early sensory experience, extensive experience with heteromodal cues and, above all, maturation of cooperative interactions between superior colliculus and cortex [6,7]. The ability to engage in multisensory integration specifically requires cortical influences [8,9]: without the help of cortical activity, neurons become responsive to multiple sensory modalities, but are unable to ...

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Regional Specificity of GABAergic Regulation of Cross-Modal Plasticity in Mouse Visual Cortex after Unilateral Enucleation

Cited by 16 publications

References 120 publications

A Tool for Brain-Wide Quantitative Analysis of Molecular Data upon Projection into a Planar View of Choice

A Tool for Brain-Wide Quantitative Analysis of Molecular Data upon Projection into a Planar View of Choice

Retinal lesions induce fast intrinsic cortical plasticity in adult mouse visual system

A Symmetric Approach Elucidates Multisensory Information Integration

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