Regional study of the co-localization of neuronal nitric oxide synthase with muscarinic receptors in the rat cerebral cortex

Moro, Véronique; Badaut, Jérôme; Springhetti, V.; Edvinsson, Lars; Seylaz, Jacques; Lasbennes, François

doi:10.1016/0306-4522(95)00285-q

Cited by 38 publications

(20 citation statements)

References 57 publications

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“…Additionally, basal forebrain-induced increase in cortical blood flow is not only sensitive to muscarinic and nicotinic blockade but also to NO synthase inhibition (for review, see Hamel, 2004). NOS interneurons, via muscarinic activation (Moro et al, 1995), may modulate perivascular release of NO, which then either directly dilates microvessels or assists in the relaxing effect of ACh on cortical microarterioles (Elhusseiny and Hamel, 2000;Hamel, 2004). Similarly, the changes in cortical perfusion elicited by dorsal raphe stimulation could involve 5-HT3 receptor-mediated activation of VIP interneurons (Ferezou et al, 2002) as well as other serotonin-responsive interneurons (Foehring et al, 2002) equally contacted by 5-HT terminals (Paspalas and Papadopoulos, 2001; our study).…”

Section: Afferent Inputs To Different Subsets Of Gaba Neurons and Funmentioning

confidence: 99%

Cortical GABA Interneurons in Neurovascular Coupling: Relays for Subcortical Vasoactive Pathways

Cauli¹,

Tong²,

Rancillac³

et al. 2004

J. Neurosci.

519

530

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Section: Afferent Inputs To Different Subsets Of Gaba Neurons and Funmentioning

confidence: 99%

Cortical GABA Interneurons in Neurovascular Coupling: Relays for Subcortical Vasoactive Pathways

Cauli¹,

Tong²,

Rancillac³

et al. 2004

J. Neurosci.

519

530

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“…In the cortex, the main sources of ACh are terminals originating from the nucleus basalis (Johnston et al, 1979;Struble et al, 1986), and in the hippocampus, fibers which originate from the septum (Hasselmo and Bower, 1993). Stimulation of the nucleus basalis not only induces h-and superimposed c-oscillations (Lamour et al, 1986;McLin et al, 2003), but also leads to a rapid neurovascular response (Moro et al, 1995). Activation of the septum has similar effects in the hippocampus (Vandecasteele et al, 2014).…”

Section: Introductionmentioning

confidence: 96%

No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro

et al. 2015

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“…NO is well known to play crucial roles in the induction or regulation of neuronal plasticity (Garthwaite and Boulton, 1995) and is involved in various neuronal functions such as learning and memory (Rancillac and Crepel, 2004; Garthwaite, 2008), neuronal death (Dawson and Dawson, 1998; Kiss, 2000), and cerebral blood flow control (Iadecola et al, 1993; Moro et al, 1995; Rancillac et al, 2006). Despite these pleiotropic effects of prime importance, cortical nNOS-expressing neurons are still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse

Perrenoud

Geoffroy²,

Gauthier³

et al. 2012

Front. Neural Circuits

114

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In the neocortex, neuronal nitric oxide (NO) synthase (nNOS) is essentially expressed in two classes of GABAergic neurons: type I neurons displaying high levels of expression and type II neurons displaying weaker expression. Using immunocytochemistry in mice expressing GFP under the control of the glutamic acid decarboxylase 67k (GAD67) promoter, we studied the distribution of type I and type II neurons in the barrel cortex and their expression of parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptide (VIP). We found that type I neurons were predominantly located in deeper layers and expressed SOM (91.5%) while type II neurons were concentrated in layer II/III and VI and expressed PV (17.7%), SOM (18.7%), and VIP (10.2%). We then characterized neurons expressing nNOS mRNA (n = 42 cells) ex vivo, using whole-cell recordings coupled to single-cell reverse transcription-PCR and biocytin labeling. Unsupervised cluster analysis of this sample disclosed four classes. One cluster (n = 7) corresponded to large, deep layer neurons, displaying a high expression of SOM (85.7%) and was thus very likely to correspond to type I neurons. The three other clusters were identified as putative type II cells and corresponded to neurogliaform-like interneurons (n = 19), deep layer neurons expressing PV or SOM (n = 9), and neurons expressing VIP (n = 7). Finally, we performed nNOS immunohistochemistry on mouse lines in which GFP labeling revealed the expression of two specific developmental genes (Lhx6 and 5-HT3A). We found that type I neurons expressed Lhx6 but never 5-HT3A, indicating that they originate in the medial ganglionic eminence (MGE). Type II neurons expressed Lhx6 (63%) and 5-HT3A (34.4%) supporting their derivation either from the MGE or from the caudal ganglionic eminence (CGE) and the entopeduncular and dorsal preoptic areas. Together, our results in the barrel cortex of mouse support the view that type I neurons form a specific class of SOM-expressing neurons while type II neurons comprise at least three classes.

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Regional study of the co-localization of neuronal nitric oxide synthase with muscarinic receptors in the rat cerebral cortex

Cited by 38 publications

References 57 publications

Cortical GABA Interneurons in Neurovascular Coupling: Relays for Subcortical Vasoactive Pathways

Cortical GABA Interneurons in Neurovascular Coupling: Relays for Subcortical Vasoactive Pathways

No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro

Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse

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