2007
DOI: 10.1016/j.jinf.2007.04.006
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Regional trends in β-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001–2004

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Cited by 108 publications
(87 citation statements)
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References 31 publications
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“…The combination of β-lactam and macrolide covers the most common possible pathogens involved in the pathogenesis of pneumonia. 5 More recently, fluoroquinolones with enhanced activity against Streptococcus pneumoniae were introduced in clinical practice. The favourable pharmacokinetic profile of fluoroquinolones allows for once daily administration, often eliminating the need for parenteral treatment.…”
mentioning
confidence: 99%
“…The combination of β-lactam and macrolide covers the most common possible pathogens involved in the pathogenesis of pneumonia. 5 More recently, fluoroquinolones with enhanced activity against Streptococcus pneumoniae were introduced in clinical practice. The favourable pharmacokinetic profile of fluoroquinolones allows for once daily administration, often eliminating the need for parenteral treatment.…”
mentioning
confidence: 99%
“…The peptidoglycan (PG) is an important component of the cell surface of all bacteria (reviewed in references 8, 61, 65-67, and 73) and is the target for several antibiotics, including ␤-lactam antibiotics and vancomycin, used to treat pneumococcal infections (55,68). Notably, resistance of S. pneumoniae to ␤-lactam antibiotics is increasing at an alarming rate due to multiple amino acid changes in the pneumococcal penicillin binding proteins (PBPs) (13,23,33,36,72).…”
mentioning
confidence: 99%
“…Many genes involved in bacterial adaptation, survival, and virulence encode enzymes that mediate central metabolism and maximize energy production (44). These links are only starting to be studied systematically in S. pneumoniae, and they provide promise in identifying targets for antibiotic development to combat emerging multidrug resistance (12,29).…”
mentioning
confidence: 99%