Regional Variations of Low-Density Lipoprotein Oxidizability in Hemodialysis Patients May Explain Discrepancies in Interventional Therapy on Oxidative Profile

Moréna, Marion; Gausson, Valérie; Mothu, Nadya; Bouchet, Jean-Louis; Chanas, M.; Grandvuillemin, M; Robert, Alain; Vela, Carlos; Canaud, Bernard; Cristol, Jean‐Paul; Olmer, M

doi:10.1159/000128991

Cited by 10 publications

(7 citation statements)

References 70 publications

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“…It is worthy of consideration, however, that such controversial data could be partially explained by regional variations of the low-density lipoprotein oxidizability which were demonstrated in HD patients by Morena et al [44] .…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Metabolites, Leukocyte Activation Markers and Oxidative Status in Dialyzed Subjects

Caimi

Carollo²,

Montana³

et al. 2009

Blood Purif

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Aims: Our purpose was to evaluate, in a group of 42 end-stage renal disease patients who regularly undergo hemodialysis, some indexes of leukocyte activation, nitric oxide metabolites (NOx) and other parameters that reflect the oxidative stress before and after a standard hemodialysis session. Methods: Elastase and myeloperoxidase (MPO) were determined by means of ELISA. The NO production was evaluated by a micromethod which measures the concentration of NOx. The oxidation of polyunsaturated fatty acids was evaluated in plasma by detection of thiobarbituric acid-reactive substances (TBARS). Total antioxidant status (TAS) was obtained using spectrophotometry. Results: At baseline, we observed an increase of elastase, NOx, TBARS and TAS, without any variation of MPO. After the dialysis session, we found an increase in elastase and MPO, a decrease in NOx and TAS and no variation in TBARS. No modification occurred after subdividing the patients in two subgroups. Conclusions: Our data confirm the involvement of leukocytes and oxidative stress in hemodialysis patients.

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Section: Discussionmentioning

confidence: 99%

Nitric Oxide Metabolites, Leukocyte Activation Markers and Oxidative Status in Dialyzed Subjects

Caimi

Carollo²,

Montana³

et al. 2009

Blood Purif

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“…A meta-analysis of 10 studies [11,31,48,51,58,64,66,68,70,71] indicated that ViE-m did not influence triglycerides levels (307 patients; MD 4.00 mg/dl; 95% CI -5.41 to 13.41, chi 2 = 2.99, p = 0.96; I 2 = 0%; fig. 11 a).…”

Section: Effects Of Vie-m On Other Outcomesmentioning

confidence: 99%

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

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Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.

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“…Another small randomized study [102], however, failed to observe a different extent of LDL oxidizability in patients treated for 3 months with vitamin E-coated membranes that were compared with perspective crossover design to reference PS membrane. At the same time, however, the authors reported for this multicenter study that LDL oxidizability showed marked intercenter (or regional) variability, which may suggest the introduction of local biases in the selection of patients and treatments.…”

Section: Vitamin E-bonded Dialyzersmentioning

confidence: 99%

Vitamin E as a Functional and Biocompatibility Modifier of Synthetic Hemodialyzer Membranes: An Overview of the Literature on Vitamin E-Modified Hemodialyzer Membranes

et al. 2012

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Along with one century of history, research has provided many solutions for hemodialysis (HD) biomaterials, encompassing several generations of copolymers that have found wide application in the development of hollow-fiber dialyzer membranes. Polysulfone-based biomaterials have gained increasing consideration and are now the gold standard in the production of biocompatible hemodialyzers. However, even the highest biocompatibility now available cannot exclude that dialyzer membranes and the overall extracorporeal circulation may produce at the subclinical level immunoinflammatory reactions and thus an increased cardiovascular risk of patients on regular HD therapy. The lipophilic antioxidant and radical scavenger vitamin E has been used (as α-tocopherol) to modify cellulosic and synthetic hollow-fiber membranes with the ultimate goal to neutralize harmful reactive species and to mimic lipid structures of blood cell plasmalemma and lipoprotein particles. Besides filtration and biocompatibility, this modifier has introduced a third function of dialyzer membranes, namely ‘antioxidant bioactivity’. Vitamin E can also serve as a template molecule to produce synthetic redox-active and -silent (non-antioxidant) modifiers for future generations of dialyzer membranes. This mini-review article describes the evolution of vitamin E-derived copolymers as a generation of biomaterials that has offered a clinical challenge and still represents a chance to further improving the quality of HD therapy.

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Regional Variations of Low-Density Lipoprotein Oxidizability in Hemodialysis Patients May Explain Discrepancies in Interventional Therapy on Oxidative Profile

Cited by 10 publications

References 70 publications

Nitric Oxide Metabolites, Leukocyte Activation Markers and Oxidative Status in Dialyzed Subjects

Nitric Oxide Metabolites, Leukocyte Activation Markers and Oxidative Status in Dialyzed Subjects

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Vitamin E as a Functional and Biocompatibility Modifier of Synthetic Hemodialyzer Membranes: An Overview of the Literature on Vitamin E-Modified Hemodialyzer Membranes

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