Regional White Matter Diffusion Changes Associated with the Cumulative Tensile Strain and Strain Rate in Nonconcussed Youth Football Players

Holcomb, James M.; Fisicaro, Ryan A.; Miller, Logan E.; Yu, Fang; Davenport, Elizabeth M.; Xi, Yin; Urban, Jillian E.; Wagner, Ben; Powers, Alexander K.; Whitlow, Christopher T.; Stitzel, Joel D.; Maldjian, Joseph A.

doi:10.1089/neu.2020.7580

Cited by 7 publications

(27 citation statements)

References 63 publications

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“…• These radiating fibres project posteriorly and converge in the internal capsule above the superior border of the lentiform nucleus. From here, they continue past the basal ganglia and terminate at the thalamus and brainstem nuclei (Emos & Agarwal, 2021) • Anteriorly, this bundle synapses with the internal capsule, facilitating emotion processing, cognition, decision making, and motivation (Safadi et al, 2018) • Posteriorly they merge with fibers of the posterior thalamic radiation, corticospinal tract, corticorubral tract, and corticopontine tract which are implicated in the primary motor cortex and premotor areas (Emos & Agarwal, 2021) • Well reported in mTBI literature (Holcomb et al, 2021;Kasahara et al, 2012;Mayer et al, 2010;Niogi et al, 2008) and thought to be particularly susceptible to axonal injury due to its configuration (Holcomb et al, 2021).…”

Section: White Matter Tracts In Mtbimentioning

confidence: 99%

“…Well reported in mTBI literature (Holcomb et al., 2021 ; Kasahara et al., 2012 ; Mayer et al., 2010 ; Niogi et al., 2008 ) and thought to be particularly susceptible to axonal injury due to its configuration (Holcomb et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…As one of the most biomechanically vulnerable tracts in mTBI (Holcomb et al., 2021 ; Zhao et al., 2017 ), the SLF has been frequently associated with abnormal diffusion in mTBI (MacDonald et al., 2018 ; Murdaugh et al., 2018 ), including subconcussive impacts (Bahrami et al., 2016 ; Sollmann et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…Multiple groups have shown damage to the cingulum bundle in mTBI (Davenport et al., 2012 ; Levine et al., 2008 ), and subconcussive impacts (Barber Foss et al., 2019 ; Holcomb et al., 2021 ; I. Jang et al., 2019 ), resulting in reduced self‐paced saccades (Taghdiri et al., 2018 )…”

Section: Introductionmentioning

confidence: 99%

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A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings

et al. 2022

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Mild traumatic brain injury (mTBI), commonly known as concussion, is a complex neurobehavioral phenomenon affecting six in 1000 people globally each year. Symptoms last between days and years as microstructural damage to axons and neurometabolic changes result in brain network disruption. There is no clinically available objective biomarker to diagnose the severity of injury or monitor recovery. However, emerging evidence suggests eye movement dysfunction (e.g., saccades and smooth pursuits) in patients with mTBI. Patients with a higher symptom burden and prolonged recovery time following injury may show higher degrees of eye movement dysfunction. Likewise, recent advances in magnetic resonance imaging (MRI) have revealed both white matter tract damage and functional network alterations in mTBI patients, which involve areas responsible for the ocular motor control. This scoping review is presented in three sections: Section 1 explores the anatomical control of eye movements to aid the reader with interpreting the discussion in subsequent sections. Section 2 examines the relationship between abnormal MRI findings and eye tracking after mTBI based on the available evidence. Finally, Section 3 communicates gaps in our knowledge about MRI and eye tracking, which should be addressed in order to substantiate this emerging field.

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Section: White Matter Tracts In Mtbimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings

et al. 2022

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“…Ultimately, complex behaviors and cognition arise from brain structural and functional organization, which is disturbed in a dose-dependent manner by a single season of head mechanical loading [ 16 , 17 , 18 , 19 ], after many years of exposure in retired professional athletes [ 20 , 21 , 22 , 23 ], and in patients with various tauopathies [ 24 , 25 ]. It is increasingly understood that relationship between structure and function, so-called structure–function (de)coupling, is more strongly associated with age than either constituent measure [ 26 , 27 ] and is disrupted in neurodegenerative diseases [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Trajectories of Brain Structure–Function Coupling in Female Roller Derby Athletes

et al. 2021

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Contact and collision sports are believed to accelerate brain aging. Postmortem studies of the human brain have implicated tau deposition in and around the perivascular space as a biomarker of an as yet poorly understood neurodegenerative process. Relatively little is known about the effects that collision sport participation has on the age-related trajectories of macroscale brain structure and function, particularly in female athletes. Diffusion MRI and resting-state functional MRI were obtained from female collision sport athletes (n = 19 roller derby (RD) players; 23–45 years old) and female control participants (n = 14; 20–49 years old) to quantify structural coupling (SC) and decoupling (SD). The novel and interesting finding is that RD athletes, but not controls, exhibited increasing SC with age in two association networks: the frontoparietal network, important for cognitive control, and default-mode network, a task-negative network (permuted p = 0.0006). Age-related increases in SC were also observed in sensorimotor networks (RD, controls) and age-related increases in SD were observed in association networks (controls) (permuted p ≤ 0.0001). These distinct patterns suggest that competing in RD results in compressed neuronal timescales in critical networks as a function of age and encourages the broader study of female athlete brains across the lifespan.

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White matter hyperintensities in former American football players

Alosco

Tripodis

Baucom

et al. 2022

Alzheimer's & Dementia

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Introduction:The presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden and distribution of WMH, and their association with years of play, age of first exposure, and clinical function in former American football players.Methods: A total of 149 former football players and 53 asymptomatic unexposed participants (all men, 45-74 years) completed fluid-attenuated inversion recovery magnetic resonance imaging, neuropsychological testing, and self-report neuropsychiatric measures. Lesion Segmentation Toolbox estimated WMH. Analyses were performed in the total sample and stratified by age 60. Results:In older but not younger participants, former football players had greater total, frontal, temporal, and parietal log-WMH compared to asymptomatic unexposed men. In older but not younger former football players, greater log-WMH was associated with younger age of first exposure to football and worse executive function.Discussion: In older former football players, WMH may have unique presentations, risk factors, and etiologies.

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Regional White Matter Diffusion Changes Associated with the Cumulative Tensile Strain and Strain Rate in Nonconcussed Youth Football Players

Cited by 7 publications

References 63 publications

A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings

A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings

Age-Related Trajectories of Brain Structure–Function Coupling in Female Roller Derby Athletes

White matter hyperintensities in former American football players

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