Regionally differentiated fibrinolytic responses during volume‐resuscitated acute endotoxemia in pigs

Abstract

Acute endotoxemia induces a prompt, marked and regionally differentiated pro-fibrinolytic response that cannot be discerned based on systemic levels of circulating tPA and that was normalized during volume resuscitation.

Pulmonary net release of tissue‐type plasminogen activator during porcine primary and secondary acute lung injury

“…In contrast, a previous study in pigs failed to demonstrate that tPA is actively secreted by the pulmonary endothelial cells to yield a positive net pulmonary flux of tPA (2). Pulmonary net release of tPA tended to increase transiently in porcine acute endotoxinemia (3).…”

“…Tissue-type plasminogen activator (tPA) is a key mediator of vascular fibrinolysis to support microvascular patency. Pulmonary net release of tPA tended to increase transiently in porcine acute endotoxinemia (3). In contrast, a previous study in pigs failed to demonstrate that tPA is actively secreted by the pulmonary endothelial cells to yield a positive net pulmonary flux of tPA (2).…”

“…The protocol period of 2 h was chosen for this study based on previous work demonstrating peak responses for tPA (3) and TNFa-induced tPA release (8) within this time frame. The present study can only address differences in the acute pathophysiology of ALI.…”

Time‐ and dose‐related regional fluxes of tissue‐type plasminogen activator in anesthetized endotoxemic pigs

“…We have recently demonstrated that acute endotoxemia‐induced circulatory failure in pigs results in increased plasma levels of tPA, and specifically a mesenteric release along with a hepatic uptake of tPA (6). The amount and timing of endotoxin administration, the hemodynamic response and support and the magnitude of the inflammatory response may all have an impact on the fibrinolytic response.…”