Regioselective Heterocyclization of Phosphoryl‐α‐chloroacetaldehydes with 2,3‐Diaminopyridine.

Abstract

Organo-phosphorus compoundsOrgano-phosphorus compounds S 0080 Regioselective Heterocyclization of Phosphoryl-α-chloroacetaldehydes with 2,3-Diaminopyridine. -(ASADOV, K. A.; BURANGULOVA, R. N.; GUSEINOV, F. I.; GIL'MANOV, R. Z.; PHALJACHOV, I. P.; Chem. Heterocycl. Compd. (N. Y.) 39 (2003) 3, 392-393; Kazan State Technol. Univ., Kazan' 420015, Russia; Eng.) -Staver 45-149

Synthesis and anticancer activity of some new pyridine derivatives

“…Cytotoxic and biological effects of tested compounds against liver cancer cell line Compounds 3,4,5,6,7,8,10,11,12,13,17, and 18 were soluble in DMSO at concentrations high enough to allow cell experiments; the in vitro biological activity of these compounds was evaluated by their growth-inhibitory potency in liver HEPG2 cancer cell lines. The cytotoxic potency of compounds 3,4,5,6,7,8,10,11,12,13,17, and 18 were studied in comparison to the known anticancer drugs 5-flurouracil (5-FU) and doxorubicin (DOX).…”

“…Group (3): each mouse was given a single intraperitoneal injection of 0.1 mL containing 12 mg/kg body weight of the tested compounds (3,4,5,6,7,8,10,11,12,13,17 and 18, respectively) dissolved in DMSO. Blood was collected after 7 days from all mice groups.…”

“…Twenty tested compounds (3,4,5,6,7,8,10,11,12,13,17, and 18) were subjected to a screening system for investigation of their antitumor potency against liver (HEPG2) cell line. Moreover, the biochemical effects of the tested compounds on some enzymes such as aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP), in addition to albumin, globulins, creatinine, total lipids, cholesterol, triglycerides and bilirubin in serum of mice were studied in comparison to 5-flurouracil and doxorubicin.…”

“…N-acyl pyridine derivatives have also attracted considerable attention due to their hydrogen bonding motifs [1][2][3]. Poly functional pyridines are highly reactive reagents that have been used extensively in heterocyclic synthesis [4][5][6][7] and that possess biological as well as pharmacological activity [8][9][10]. In addition, triazolopyridines are also interesting compounds due to their pronounced biological activity, as they can be used as antidepressants [11][12][13].…”

Synthesis and antifungal activity of novel polyheterocyclic compounds containing fused 1,2,4-triazine moiety

“…Polyfunctional pyridines are highly reactive reagents that have been used extensively in heterocyclic synthesis [1][2][3] and that possess biological as well as pharmacological activity. [4][5][6] Triazolopyridines are also interesting compounds due to their pronounced biological activity, as they can be used as antidepressants.…”