Regioselective Modification at the 2,3- and 6-Positions of Chitosan with Phenylcarbamates for Efficient Chromatographic Enantioseparation

Deng, Hongzhong; Qiao, Yingjie; Zheng, Ting; Bai, Chengying; Wang, Guixiang; Zhang, Lili; Shen, Jun

doi:10.2139/ssrn.4524982

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“…Hydrogen bonds were considered to be substantial in the separation process. Another study also evaluated the effect of regioselective modifications of 2, 3, and 6 positions of chitosan [87]. In this case, the 2‐amino and 3‐hydroxy groups contained 3,5‐dimethylphenyl substituents, while the 6‐hydroxy group displayed a 4‐chlorophenyl or a 3,5‐dichlorophenyl moiety.…”

Section: Chiral Selectorsmentioning

confidence: 99%

Update on chiral recognition mechanisms in separation science

Scriba

2024

J of Separation Science

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The stereospecific analysis of chiral molecules is an important issue in many scientific fields. In separation sciences, this is achieved via the formation of transient diastereomeric complexes between a chiral selector and the selectand enantiomers driven by molecular interactions including electrostatic, ion‐dipole, dipole‐dipole, van der Waals or π‐π interactions as well as hydrogen or halogen bonds depending on the nature of selector and selectand. Nuclear magnetic resonance spectroscopy and molecular modeling methods are currently the most frequently applied techniques to understand the selector‐selectand interactions at a molecular level and to draw conclusions on the chiral separation mechanism. The present short review summarizes some of the recent achievements for the understanding of the chiral recognition of the most important chiral selectors combining separation techniques with molecular modeling and/or spectroscopic techniques dating between 2020 and early 2024. The selectors include polysaccharide derivatives, cyclodextrins, macrocyclic glycopeptides, proteins, donor‐acceptor type selectors, ion‐exchangers, crown ethers, and molecular micelles. The application of chiral ionic liquids and chiral deep eutectic solvents, as well as further selectors, are also briefly addressed. A compilation of all published literature on chiral selectors has not been attempted.

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Section: Chiral Selectorsmentioning

confidence: 99%

Update on chiral recognition mechanisms in separation science

Scriba

2024

J of Separation Science

View full text Add to dashboard Cite

show abstract

Regioselective Modification at the 2,3- and 6-Positions of Chitosan with Phenylcarbamates for Efficient Chromatographic Enantioseparation

Cited by 1 publication

References 0 publications

Update on chiral recognition mechanisms in separation science

Update on chiral recognition mechanisms in separation science

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