Regioselective synthesis and S-derivatization reactions of 4- and 6-trifluoromethyl-3-cyano-2(1H)-pyridinethiones

The Chemistry of α-Haloketones and Their Utility in Heterocyclic Synthesis

“…Some of the most interesting derivatives of thiophenes are 3-aminothieno[2,3- b ]pyridines, in view of their wide spectrum of high biological activities and valuable pro-perties in many applications [ 202 , 203 , 204 ]. It is noteworthy that investigators [ 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 ] have de-voted considerable attention in recent years to the synthesis of thieno[2,3- b ]pyridines 101 via S -alkylation of 3-cyanopyridine-2(1 H )-thiones 99 with α-haloketones ( Scheme 28 ).…”

Synthesis of 3-cyano-2-fluoropyridines

“…We also investigated the utility of readily available 3-cyanopyridine-2(1H)-thiones [25][26][27] as starting materials for the synthesis of Biologically active 3-cyano-2-fluoropyridines. These compounds were first converted into 3-cyano-2-methanesulphonylpyridines 4 by a previously published protocol [28].…”

The Chemistry of α‐Haloketones and Their Utility in Heterocyclic Synthesis

“…Some of the most interesting derivatives of thiophenes are 3-aminothieno [2,3-b]pyridines, in view of their wide spectrum of high biological activities and valuable properties in many applications [202][203][204]. It is noteworthy that investigators have devoted considerable attention in recent years to the synthesis of thieno[2,3-b]pyridines 101 via S-alkylation of 3-cyanopyridine-2(1H)-thiones 99 with α-haloketones (Scheme 28).…”