Regioselective Synthesis of 6‐Prenylpolyhydroxyisoflavone (Wighteone) and Wighteone Hydrate with Hypervalent Iodine.

Hossain, Mohammad Mamun; Tokuoka, Takanori; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao

doi:10.1002/chin.200636196

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“…Six metabolites, notably paeoniflorin and glabridin, were found to have increased expression, while others including kaempferol 3-O-(6'-O-acetyl) glucoside, malonyl daidzein, ononin and baicalin found to have decreased expression (Table 3). The up-regulated substances exhibit antioxidative and free radical scavenging properties, which protect alfalfa roots from the toxic effects of OCA and minimize oxidative damage [27][28][29][30][31][32][33][34][35]. The differential metabolites were categorised into 7 biological processes associated with KEGG analysis with a high level of significance (P < 0.05).…”

Section: Qualitative and Quantitative Analysis Of Different Flavonoid...mentioning

confidence: 99%

Quantitative proteomics and metabolomics analysis reveals the response mechanism of alfalfa (Medicago sativa L.) to o-coumaric acid stress

Xu,

Geng,

Sun

2023

PLoS ONE

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O-coumaric acid (OCA), as a significant phenolic allelochemical found in hairy vetch (Vicia villosa Roth.), that can hinder the growth of alfalfa (Medicago sativa L.), particularly the growth of alfalfa roots. Nonetheless, the mechanism by which OCA inhibits alfalfa root growth remains unclear. In this study, a liquid chromatography tandem mass spectrometry (LC-MS/MS)-based quantitative proteomics analysis was carried out to identify differentially accumulated proteins (DAPs) under OCA treatment. The findings indicated that 680 proteins were DAPs in comparison to the control group. Of those, 333 proteins were up-regulated while 347 proteins were down-regulated. The enrichment analysis unveiled the significance of these DAPs in multiple biological and molecular processes, particularly in ribosome, phenylpropanoid biosynthesis, glutathione metabolism, glycolysis/gluconeogenesis and flavonoid biosynthesis. The majority of DAPs reside in the cytoplasm (36.62%), nucleus (20.59%) and extracellular space (14.12%). In addition, phenylalanine deaminase was identified as a potential chemical-induced regulation target associated with plant lignin formation. DAPs were mainly enriched in flavonoid biosynthesis pathways, which were related to plant root size. Using the UPLC-ESI-MS/MS technique and database, a total of 87 flavonoid metabolites were discovered. The metabolites were predominantly enriched for biosynthesizing naringenin chalcone, which was linked to plant lignin formation, aligning with the enrichment outcomes of DAPs. Consequently, it was deduced that OCA impacted the structure of cell walls by mediating the synthesis of lignin in alfalfa roots, subsequently inducing wilt. Furthermore, a range of proteins have been identified as potential candidates for the breeding of alfalfa strains with enhanced stress tolerance.

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Section: Qualitative and Quantitative Analysis Of Different Flavonoid...mentioning

confidence: 99%

Quantitative proteomics and metabolomics analysis reveals the response mechanism of alfalfa (Medicago sativa L.) to o-coumaric acid stress

Xu,

Geng,

Sun

2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

Regioselective Synthesis of 6‐Prenylpolyhydroxyisoflavone (Wighteone) and Wighteone Hydrate with Hypervalent Iodine.

Cited by 1 publication

References 1 publication

Quantitative proteomics and metabolomics analysis reveals the response mechanism of alfalfa (Medicago sativa L.) to o-coumaric acid stress

Quantitative proteomics and metabolomics analysis reveals the response mechanism of alfalfa (Medicago sativa L.) to o-coumaric acid stress

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