2019
DOI: 10.1002/ange.201906264
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Regioselective Synthesis of Fused Furans by Decarboxylative Annulation of α,β‐Alkenyl Carboxylic Acid with Cyclic Ketone: Synthesis of Di‐Heteroaryl Derivatives

Abstract: a,b-Alkenyl carboxylicacids undergo Cu II -mediated decarboxylative annulation reactions with aliphatic cyclic ketones to provides ynthetically valuable di-heterocycles.T he annulation process tolerates avariety of aliphatic ketones and heterocyclic alkenyl carboxylic acids,p roducing substituted fused furan derivatives with complete regioselectivity.T he current protocol offers as ynthetically applicable pathway to construct avariety of oligo-heterocycles through Cu-mediated single-electron transfer and decar… Show more

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Cited by 8 publications
(1 citation statement)
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“…reported a new copper‐mediated cyclization reaction of cyclic ketones with α , β ‐alkenyl carboxylic acids to access precious di ‐heterocycles (Scheme 12). [25] The cyclization process could be tolerated for various aliphatic ketones 72 and heterocyclic alkenyl carboxylic acids 73 , generating substituted furan derivatives 74 with high regioselectivity. Notably, increasing the ring size of ketone partners to a 15‐membered ring did not affect the reaction, illustrating the generality of the current procedure.…”
Section: Metal‐catalyzed Decarboxylative Cyclizationmentioning
confidence: 99%
“…reported a new copper‐mediated cyclization reaction of cyclic ketones with α , β ‐alkenyl carboxylic acids to access precious di ‐heterocycles (Scheme 12). [25] The cyclization process could be tolerated for various aliphatic ketones 72 and heterocyclic alkenyl carboxylic acids 73 , generating substituted furan derivatives 74 with high regioselectivity. Notably, increasing the ring size of ketone partners to a 15‐membered ring did not affect the reaction, illustrating the generality of the current procedure.…”
Section: Metal‐catalyzed Decarboxylative Cyclizationmentioning
confidence: 99%