Regioselective synthesis of isoxazole–mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Synthesis, crystal structure, biological activity and theoretical calculations of novel isoxazole derivatives

“…The antifungal activity of all the synthetic compounds were evaluated against four plants Pathogenic fungis. antituberculosis [1], antiinflammatory [2], cytotoxic [3] properties. Especially, many isoxazole compounds have been developed as marketed products, such as leflunomide, sulfafurazole, and isoxaflutole and hymexazol.…”

Substituent effect study on experimental 13C NMR chemical shifts of (3-(substituted phenyl)-cis-4,5-dihydroisoxazole-4,5-diyl)bis(methylene)diacetate derivatives

“…Isoxazole derivatives are a class of heterocyclic compounds having a wide a range of properties such as immunosuppressive [1], antimicrobial [2,3] antibacterial [4], antioxidant and anti-inflammatory [5], cytotoxic [6], antimycobacterial [7], analgesic [8], muscarinic [9], antitubulin [10], anticoagulant [11], antituberculosis [12] activities, anticancer [13,14], DNA-intercalating [15], antiproliferative [16] agents, firefly luciferase (Luc) [17], human transglutaminase 2 [18] inhibitors, estrogen receptor a and b agonists [19]. 4,5-Dihydroisoxazoles are useful intermediates in organic synthesis such as synthesis of b-hydroxy ketones, c-amino alcohols, a, b-unsaturated oximes, and b-hydroxy nitriles [20][21][22][23][24][25][26][27].…”

Synthesis andIn VitroCytotoxic Activity of Novel Triazole-Isoxazole Derivatives

“…1,2,3‐Triazoles have been highly recognized because of their cytotoxic , anti‐HIV‐1 , anti‐influenza , anti‐platelet , and anti‐tuberculosis activities. Likewise, isoxazole derivatives have attracted enormous attention for their anti‐depression , antipyretics , anti‐inflammatory , and also anti‐tuberculosis properties. It seems that the combination of 1,2,3‐triazole and isoxazole scaffolds leads to the formation of compounds possessing promising biological activities.…”