Regiospecific deoxygenative deuteration of ketones <i>via</i> HOME chemistry

Gui, Ruohua; Li, Chao‐Jun

doi:10.1039/d3qo00143a

Cited by 4 publications

(1 citation statement)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to conveniently obtain deuterated compounds to meet the demands of deuterated molecule research, organic chemists have developed many novel deuteration methods in recent years that are mild, efficient, and highly selective. These novel methods can be classified based on the different functional groups of the substrates, including deuteration of unsaturated bond, 12 deuteration of halogen bond, 13 decarboxylative deuteration, 14,15 deoxygenative deuteration, 16 deamination deuteration, 17 and so on. 18,19 Among these novel methods, decarboxylative deuteration has been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Progress in the decarboxylative deuteration reaction of alkyl carboxylic acids

Dong,

Yang,

Wang

et al. 2023

Applied Organom Chemis

View full text Add to dashboard Cite

The application of deuterated compounds is increasingly expanding across various fields, making the development of novel deuterium labeling techniques for obtaining deuterated compounds a burgeoning research focus. Carboxylic acids and their derivatives are widely utilized as cost‐effective and readily available materials for obtaining deuterated compounds due to their stable properties. This article presents a comprehensive and concise summary of the research progress in decarboxylative deuteration reactions over the past 20 years.

show abstract

Section: Introductionmentioning

confidence: 99%

Progress in the decarboxylative deuteration reaction of alkyl carboxylic acids

Dong,

Yang,

Wang

et al. 2023

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Recent advances in late‐stage selective deuteration for drug development

Wang,

Luo,

Luo

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

Deuteration has emerged as a significant method for investigating kinetic isotope effects in chemical reactions. In recent years, research on deuteration has revealed that this reaction often alters the pharmacokinetic or toxicological properties of drug molecules, thereby enhancing their therapeutic effect. Therefore, deuteration is considered as a potential avenue for drug research direction. Since the approval of the first deuterated drug, “deutetrabenazine,” by the American Food and Drug Administration (FDA) in 2017, deuteration has been applied in the development of a variety of novel drugs. Research on deuteration technology has matured with the publication of numerous deuteration strategies. This article reviews recently reported strategies for late‐stage selective deuteration, discusses the challenges associated with current deuteration strategies, and presents future prospects for the synthesis of deuterated drugs.

show abstract

Highly effective and selective FeBr₃-promoted deuterium bromination/cyclization of 1,n-enynes

Li,

Du,

et al. 2024

Org. Biomol. Chem.

View full text Add to dashboard Cite

show abstract

Regiospecific deoxygenative deuteration of ketones via HOME chemistry

Abstract: Historically, deuteration reaction has been primarily utilized for mechanistic studies, but recently its pharmacological importance has been recognized. Many efforts have been made to fulfill the urgent need of deuteration...

Cited by 4 publications

References 68 publications

Progress in the decarboxylative deuteration reaction of alkyl carboxylic acids

Progress in the decarboxylative deuteration reaction of alkyl carboxylic acids

Recent advances in late‐stage selective deuteration for drug development

Highly effective and selective FeBr₃-promoted deuterium bromination/cyclization of 1,n-enynes

Contact Info

Product

Resources

About

Regiospecific deoxygenative deuteration of ketones via HOME chemistry

Abstract: Historically, deuteration reaction has been primarily utilized for mechanistic studies, but recently its pharmacological importance has been recognized. Many efforts have been made to fulfill the urgent need of deuteration...

Cited by 4 publications

References 68 publications

Progress in the decarboxylative deuteration reaction of alkyl carboxylic acids

Progress in the decarboxylative deuteration reaction of alkyl carboxylic acids

Recent advances in late‐stage selective deuteration for drug development

Highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes

Contact Info

Product

Resources

About

Highly effective and selective FeBr₃-promoted deuterium bromination/cyclization of 1,n-enynes