. 2008. The influence of moisture regime, N management, and cultivar on the agronomic performance and yield stability of soft white spring wheat. Can. J. Plant Sci. 88: 859Á872. Field studies were conducted for 4 yr (2000Á2003) in southern Alberta to determine the agronomic suitability and yield stability of soft white spring wheat across an array of moisture and fertility regimes. Two soft white spring wheat cultivars (AC Reed and AC Nanda) with contrasting maturity and quality profiles were compared to nine varieties representing the Canada Prairie Spring White, Canada Prairie Spring Red, and Canada Western Extra Strong wheat classes. The cultivars were managed with five varying rates of mid-row banded ammonium nitrate 0, 19, 38, 57, and 76 kg N ha (1 . AC Reed matured earlier than most cultivars except AC Vista, and had the highest average yield. Yield stability analyses showed that AC Reed was well adapted to all environments but AC Nanda was less stable. AC Vista, AC Crystal, and AC Karma had average to good stability, but produced less grain than both AC Reed and AC Nanda. For non-irrigated production, yield was generally optimized at the mid-row banded rate 38 kg N ha(1 of ammonium nitrate. Response to N varied at the irrigated sites, but sites with lower initial soil NO 3 -N levels were responsive through the 76 kg N ha(1 rate. The soft white spring wheat class responded similarly to N in all moisture regimes, but whole-grain protein accumulation was not always lowest in the soft white spring wheat class.This study indicates that long-term sustainable production of soft white spring wheat in semi-arid, non-irrigated environments is possible, and would be most successful if cultivars were selected with yield stability, maturity and protein characteristics similar to AC Reed.