REGO-ACT: assessment of physical activity during treatment with regorafenib for metastatic colorectal cancer

Piringer, Gudrun; Vormittag, Laurenz; Öhler, Leopold; Grünberger, Birgit; Meran, Johannes G.; Moshammer, Marlies; Andel, Johannes; Eisterer, Wolfgang; Trommet, Vera; Thaler, Josef

doi:10.1007/s00508-020-01703-z

Cited by 5 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Five publications [115][116][117][118] that were superseded by more recent publications and three [119][120][121] only reporting unadjusted results were excluded from any subsequent analyses. Therefore, a total of 20 publications (16 studies) on post-diagnosis physical activity, pre-to post and postdiagnosis change in physical activity levels, and post-diagnosis sedentary behaviour were included.…”

Section: Resultsmentioning

confidence: 99%

Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Markozannes,

Becerra‐Tomás,

Cariolou

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

Low physical activity and high sedentary behaviour have been clearly linked with colorectal cancer development, yet data on their potential role in colorectal cancer survival is limited. Better characterisation of these relationships is needed for the development of post‐diagnosis physical activity and sedentary behaviour guidance for colorectal cancer survivors. We searched PubMed and Embase through 28 February 2022 for studies assessing post‐diagnosis physical activity, and/or sedentary behaviour in relation to all‐cause and cause‐specific mortality and recurrence after colorectal cancer diagnosis. Total and recreational physical activity were assessed overall and by frequency, duration, intensity, and volume using categorical, linear, and non‐linear dose–response random‐effects meta‐analyses. The Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel interpreted and graded the likelihood of causality. We identified 16 observational studies on 82,220 non‐overlapping patients from six countries. Physical activity was consistently inversely associated with colorectal cancer morbidity and mortality outcomes, with 13%–60% estimated reductions in risk. Sedentary behaviour was positively associated with all‐cause mortality. The evidence had methodological limitations including potential confounding, selection bias and reverse causation, coupled with a limited number of studies for most associations. The CUP Global Expert panel concluded limited‐suggestive evidence for recreational physical activity with all‐cause mortality and cancer recurrence. Total physical activity and its specific domains and dimensions, and sedentary behaviour were all graded as limited‐no conclusion for all outcomes. Future research should focus on randomised trials, while observational studies should obtain objective and repeated physical activity measures and better adjustment for confounders.

show abstract

Section: Resultsmentioning

confidence: 99%

Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Markozannes,

Becerra‐Tomás,

Cariolou

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“… 147 In addition, wearable devices capture physical activity data in continuous, real-time, free-living settings without interrupting participants’ day-to-day. 11 , 17 , 18 , 21-23 , 25 , 40 , 44 , 45 , 51 , 62 , 63 , 66 , 76 , 83 , 85 , 86 , 89 , 90 , 92 , 104 , 108 , 111 , 112 , 119 , 122 , 126 , 128 , 129 , 136 , 139 , 142 , 143 , 147 , 157 , 158 , 161 , 163 , 166 , 172 , 173 , 176-178 , 181 , 188 , 192 , 194 , 208 Of the studies that reported on the adherence of wearable devices, 43 (70%) of them cited high adherence at greater than 80%. Additionally, feasibility studies generally noted positive experience/satisfaction using wearable devices, citing ease of use, comfort, usefulness, and no interference with daily activity related to Fitbits, ActivPal, and Biovotion AG devices.…”

Section: Discussionmentioning

confidence: 99%

The Use of Wearable Devices in Oncology Patients: A Systematic Review

Chow,

Drkulec,

et al. 2023

The Oncologist

View full text Add to dashboard Cite

Introduction The aim of this systematic review was to summarize the current literature on wearable technologies in oncology patients for the purpose of prognostication, treatment monitoring, and rehabilitation planning. Methods A search was conducted in Medline ALL, Cochrane Central Register of Controlled Trials, Embase, Emcare, CINAHL, Scopus, and Web of Science, up until February 2022. Articles were included if they reported on consumer grade and/or non-commercial wearable devices in the setting of either prognostication, treatment monitoring or rehabilitation. Results We found 199 studies reporting on 18 513 patients suitable for inclusion. One hundred and eleven studies used wearable device data primarily for the purposes of rehabilitation, 68 for treatment monitoring, and 20 for prognostication. The most commonly-reported brands of wearable devices were ActiGraph (71 studies; 36%), Fitbit (37 studies; 19%), Garmin (13 studies; 7%), and ActivPAL (11 studies; 6%). Daily minutes of physical activity were measured in 121 studies (61%), and daily step counts were measured in 93 studies (47%). Adherence was reported in 86 studies, and ranged from 40% to 100%; of these, 63 (74%) reported adherence in excess of 80%. Conclusion Wearable devices may provide valuable data for the purposes of treatment monitoring, prognostication, and rehabilitation. Future studies should investigate live-time monitoring of collected data, which may facilitate directed interventions.

show abstract

“…In other cancer survivors, mainly solid oncology tumors, actigraphy measurements have been used to objectively demonstrate a relationship between activity and physical pain and fatigue symptoms. 11 , 12 , 13 In a study involving adult hematopoietic stem cell transplant recipients, average daily steps were associated with increases in pain, fatigue, and gastrointestinal symptoms. 11 Similar studies have demonstrated altered activity patterns in cancer patients recovering postoperatively from surgery, 14 , 15 , 16 sickle cell patients experiencing painful vaso-occlusive crises, 17 and terminal cancer patients receiving pain medications.…”

Section: Introductionmentioning

confidence: 99%

Association of patient activity bio-profiles with health-related quality of life in patients with newly diagnosed multiple myeloma: a prospective observational cohort study

Korde¹,

Tavitian²,

Mastey³

et al. 2023

eClinicalMedicine

View full text Add to dashboard Cite

REGO-ACT: assessment of physical activity during treatment with regorafenib for metastatic colorectal cancer

Cited by 5 publications

References 21 publications

Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

The Use of Wearable Devices in Oncology Patients: A Systematic Review

Association of patient activity bio-profiles with health-related quality of life in patients with newly diagnosed multiple myeloma: a prospective observational cohort study

Contact Info

Product

Resources

About