Regression of Achilles tendon thickness after statin treatment in patients with familial hypercholesterolemia: An ultrasonographic study

Tsouli, Sofia; Xydis, Vasileios; Argyropoulou, Maria I.; Tselepis, Alexandros D.; Elisaf, Moses; Kiortsis, Dimitrios N.

doi:10.1016/j.atherosclerosis.2008.10.032

Cited by 59 publications

(40 citation statements)

References 31 publications

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“…Hypolipidemic treatment can induce substantial regression of eruptive, palmar and tuberous xanthomas, while decreasing plasma levels of atherogenic lipoproteins toward normal. In the early phase of tendinous xanthomas, regression can be expected after twelve months of the treatment 3,42,47 . Massive xanthomas of the Achilles tendon can require surgical reconstruction 48 .…”

Section: Prevention and Treatmentmentioning

confidence: 99%

“…Moreover, these findings can differentiate between familial hypercholesterolemia and other types of primary dyslipidemias, e.g. polygenic hypercholesterolemia, familial combined dyslipidemia 34,42 . For diagnosis of familial hypercholesterolemia, the following issues are to be considered: family history, clinical history of premature CHD, arcus senilis corneae, very high LDL cholesterol (typically above the 75 th percentile of the healthy population) on repeated measurements, and/or a causative mutation detected by molecular genetics, e.g.…”

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

“…The method of first choice is ultrasonography (US) performed 2 cms above the insertion into the calcaneum. US imaging is the less expensive nonradiating cross-sectional imaging method and depicts focal lesions that others fail to detect 42 . For familial hypercholesterolemia, increased thickness of the tendon (threshold values for age and sex are tabulated) is typical as well as loss of regular fibrous texture and the presence of echolucent areas.…”

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Xanthomas: Clinical and pathophysiological relations

A¹,

Zeman²,

Slabý³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

155

117

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Section: Prevention and Treatmentmentioning

confidence: 99%

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Xanthomas: Clinical and pathophysiological relations

A¹,

Zeman²,

Slabý³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

155

117

View full text Add to dashboard Cite

“…The regulatory response to these drugs is to increase LDLR expression, which in turn leads to decreased plasma LDL levels. Marais et al demonstrated a 57% reduce in LDL concentration after 6 weeks of atorvastatin treatment in heterozygous FH patients [160] and also, atorvastatin treatment reduced achilles tendon thickness [161] ( Table 1). Furthermore, rosuvastatin decreased LDL cholesterol by 58%, increased HDL cholesterol by 12%, [8] and reduced carotid artery intima-media thickness in FH subjects [162].…”

Section: Drugsmentioning

confidence: 97%

Familial hypercholesterolemia and triglyceride metabolism

Kolovou

Kostakou

Anagnostopoulou

2011

International Journal of Cardiology

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“…Lipomatous degeneration can be diffuse or focal. Diffuse structure changes or hypoechogenic zones are often seen in ultrasound as a sign of local xanthomas [30]. MRI shows point-shaped hyperintensities in the T2 and T1 weighting.…”

Section: Intratendinous Changes Tendinosismentioning

confidence: 99%

Achillodynia - Radiological Imaging of Acute and Chronic Overuse Injuries of the Achilles Tendon

Syha

Springer

Ketelsen

et al. 2013

Fortschr Röntgenstr

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In the past decades the incidence of acute and chronic disorders of the Achilles tendon associated with sport-induced overuse has steadily increased. Besides acute complete or partial ruptures, achillodynia (Achilles tendon pain syndrome), which is often associated with tendon degeneration, represents the most challenging entity regarding clinical diagnostics and therapy. Therefore, the use of imaging techniques to differentiate tendon disorders and even characterize structure alterations is of growing interest. This review article discusses the potential of different imaging techniques with respect to the diagnosis of acute and chronic tendon disorders. In this context, the most commonly used imaging techniques are magnetic resonance imaging (MRI), B-mode ultrasound, and color-coded Doppler ultrasound (US). These modalities allow the detection of acute tendon ruptures and advanced chronic tendon disorders. However, the main disadvantages are still the low capabilities in the detection of early-stage degeneration and difficulties in the assessment of treatment responses during follow-up examinations. Furthermore, differentiation between chronic partial ruptures and degeneration remains challenging. The automatic contour detection and texture analysis may allow a more objective and quantitative interpretation, which might be helpful in the monitoring of tendon diseases during follow-up examinations. Other techniques to quantify tendon-specific MR properties, e.?g. based on ultrashort echo time (UTE) sequences, also seem to have great potential with respect to the precise detection of degenerative tendon disorders and their differentiation at a very early stage. Key Points: Citation Format:

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Regression of Achilles tendon thickness after statin treatment in patients with familial hypercholesterolemia: An ultrasonographic study

Cited by 59 publications

References 31 publications

Xanthomas: Clinical and pathophysiological relations

Xanthomas: Clinical and pathophysiological relations

Familial hypercholesterolemia and triglyceride metabolism

Achillodynia - Radiological Imaging of Acute and Chronic Overuse Injuries of the Achilles Tendon

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