Regression of cardiac hypertrophy in hypertensive patients—comparison of Abana with propranolol

Yegnanarayan, Radha; Sangle, Shashi; Sirsikar, S. S.; Mitra, Debdeep

doi:10.1002/(sici)1099-1573(199705)11:3<257::aid-ptr79>3.0.co;2-u

Cited by 7 publications

(10 citation statements)

References 4 publications

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“…It lasted up to 42 weeks. Compared to these observations the decrease in LVM was found at 12 weeks and maintained up to 36 weeks in those patients who were kept on propanolol (Ygnanarayan et al, 1997).…”

Section: Left Ventricular Mass Lowering Effectmentioning

confidence: 53%

Terminalia arjuna Wight & Arn.—A useful drug for cardiovascular disorders

Dwivedi

2007

Journal of Ethnopharmacology

182

128

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Section: Left Ventricular Mass Lowering Effectmentioning

confidence: 53%

Terminalia arjuna Wight & Arn.—A useful drug for cardiovascular disorders

Dwivedi

2007

Journal of Ethnopharmacology

182

128

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“…Dogs receiving intravenous Terminalia showed a dose-dependent drop in blood pressure and heart rate. Two novel cardenolide cardiac glycosides were recently extracted from Terminalia's seed and root [11] [12]. By raising intracellular calcium and sodium levels, these cardenolides primarily function to strengthen cardiac contraction force [13] [14].…”

Section: Probable Mode Of Mechanismmentioning

confidence: 99%

Review: Beneficial Effect Of Bark Extract Of Terminalia Arjuna On Human Heart

Samanta,

Taladhi,

Mondal

et al. 2024

jaz

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One of the greatest agents for cardioprotection is Terminalia arjuna. Arjuna has long been regarded as the go-to plant for treating a variety of heart-related issues. It works wonders for nourishing the heart and its muscles. It is highly beneficial for the cardiac muscles' normal contraction and relaxation. Maintaining a healthy heartbeat is another benefit. Additionally, it helps to increase blood density and is particularly effective in constricting blood capillaries, which is crucial for the heart's normal function.It is also useful for widening blood vessels, works wonders for clotting blood in the event of an injury, and is generally necessary to keep blood at the right thickness. This really aids in stimulating the heart to function at its peak efficiency. This coagulation property is achieved because it has an astringent taste, or kshaya rasa. According to a study, a 70% alcoholic extract of Terminaliaarjuna caused peripheral hypotension, corroborating the plant's traditional use in traditional cardiovascular medicine. Adrenergic ß 2-receptor agonistic or direct action on the heart may be the cause of the observed effect. Comprehensive research on the active ingredients is required, as this could yield fresh perspectives on cardiovascular medications. According to a 1988 study in the Journal of Research in Education in Indian Medicine, arjuna possesses diuretic, cardio tonic, and antihypertensive qualities. The International Journal of Crude Drug Research has released information on the hypolipidaemic characteristic. It has been demonstrated to raise HDL levels. That's what the Indian Medical Gazette (1992) said. Patients with angina who take a 500 mg dose of Arjuna Bark extract along with other medications for three months report significant improvements in their treadmill test and exercise tolerance with no negative side effects. Arjuna has coenzyme Q10 as well. Patients with heart conditions are prescribed this Coenzyme Q10 in order to prevent heart attacks. Its combination effects-such as the hypolipidemic effect and dosage-dependent

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“…The mean age of the participants of all the included studies was 52.1 ± 12.8 years. A total of 18 studies reported on metoprolol [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], 11 on atenolol [39,[43][44][45][46][47][48][49][50][51][52], ten on propranolol [53][54][55][56][57][58][59][60][61][62], nine on carvedilol [46,[63][64][65][66][67][68][69][70], and four on acebutolol [43,71,...…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Each of the following BBs had one study included; bisoprolol [82], celiprolol [37], dilevalol [83], indenolol [84], nadolol [61], nipradolol [56], timolol [85], and tolamolol [53]. A total of 31 studies reported on SBP [24,[26][27][28][29]32,34,35,38,41,42,44,45,48,50,[54][55][56][57][61][62][63][64]72,73,78,79,[82][83][84]86], 28 on DBP [24,[26][27][28]32,35,38,42,[44][45][46][48]<...…”

Section: Study Characteristicsmentioning

confidence: 99%

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Exploring Sex Differences of Beta-Blockers in the Treatment of Hypertension: A Systematic Review and Meta-Analysis

et al. 2023

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Aims: In the prevention of cardiovascular morbidity and mortality, early recognition and adequate treatment of hypertension are of leading importance. However, the efficacy of antihypertensives may be depending on sex disparities. Our objective was to evaluate and quantify the sex-diverse effects of beta-blockers (BB) on hypertension and cardiac function. We focussed on comparing hypertensive female versus male individuals. Methods and results: A systematic search was performed for studies on BBs from inception to May 2020. A total of 66 studies were included that contained baseline and follow up measurements on blood pressure (BP), heart rate (HR), and cardiac function. Data also had to be stratified for sex. Mean differences were calculated using a random-effects model. In females as compared to males, BB treatment decreased systolic BP 11.1 mmHg (95% CI, −14.5; −7.8) vs. 11.1 mmHg (95% CI, −14.0; −8.2), diastolic BP 8.0 mmHg (95% CI, −10.6; −5.3) vs. 8.0 mmHg (95% CI, −10.1; −6.0), and HR 10.8 beats per minute (bpm) (95% CI, −17.4; −4.2) vs. 9.8 bpm (95% CI, −11.1; −8.4)), respectively, in both sexes’ absolute and relative changes comparably. Left ventricular ejection fraction increased only in males (3.7% (95% CI, 0.6; 6.9)). Changes in left ventricular mass and cardiac output (CO) were only reported in males and changed −20.6 g (95% CI, −56.3; 15.1) and −0.1 L (95% CI, −0.5; 0.2), respectively. Conclusions: BBs comparably lowered BP and HR in both sexes. The lack of change in CO in males suggests that the reduction in BP is primarily due to a decrease in vascular resistance. Furthermore, females were underrepresented compared to males. We recommend that future research should include more females and sex-stratified data when researching the treatment effects of hypertensives.

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Regression of cardiac hypertrophy in hypertensive patients—comparison of Abana with propranolol

Cited by 7 publications

References 4 publications

Terminalia arjuna Wight & Arn.—A useful drug for cardiovascular disorders

Terminalia arjuna Wight & Arn.—A useful drug for cardiovascular disorders

Review: Beneficial Effect Of Bark Extract Of Terminalia Arjuna On Human Heart

Exploring Sex Differences of Beta-Blockers in the Treatment of Hypertension: A Systematic Review and Meta-Analysis

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