Regression of Ocular Adnexal Lymphoma After<i>Chlamydia Psittaci</i>–Eradicating Antibiotic Therapy

Ferreri, Andrés J.M.; Ponzoni, Maurilio; Giusti, Massimo; Conciliis, Carlo de; Resti, Antonio Giordano; Mazzi, Benedetta; Lettini, Antonia Anna; Demeter, Judit; Dell’Oro, Stefania; Doglioni, Claudio; Villa, Eugenio; Boiocchi, Mauro; Dolcetti, Riccardo

doi:10.1200/jco.2005.07.083

Cited by 199 publications

(133 citation statements)

References 20 publications

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“…Micro-organisms have been implicated in the pathogenesis of MALT lymphoma arising from some locations, 16 with successful treatment by using antibiotics, most notably doxycycline for orbital MALT lymphomas. [17][18][19] However, the results are still premature to consider it as a primary modality of therapy because durable remission has only been documented in 48% in a cohort of 27 patients treated 19 and that a uniformly high response rate has not been reported by other investigators. 20 However, it is a nonmorbid treatment, and therefore an attractive initial treatment approach and can spare or delay the use of cytotoxic therapy such as RT.…”

Section: Discussionmentioning

confidence: 98%

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Goda

Gospodarowicz

Pintilie

et al. 2010

Cancer

188

126

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BACKGROUND: This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated with involved field radiotherapy (RT). METHODS: Between 1989 and 2004, 192 patients with stage I and II MALT lymphomas were treated. The report focuses on 167 patients who received RT. The median age of patients was 58 years with a female predominance (2:1). Presenting sites were as follows: orbital adnexa in 71 patients, salivary glands in 28 patients, stomach in 25 patients, thyroid in 21 patients, and other sites in 22 patients. The median dose to nonorbital sites was 30 grays (Gy) (range, 17.5-35 Gy) and was 25 Gy for the orbit (range, 25-35 Gy). The median follow-up was 7.4 years (range, 0.67-16.20 years). RESULTS: Complete response and complete response, unconfirmed (CR/CRu) was noted in 166 (99%) patients. The 10-year recurrence-free rate (RFR) was 76%, the disease-free survival (DFS) rate was 68%, the overall survival (OS) rate was 87%, and the cause-specific survival rate was 98%. According to presenting site, the 10-year RFR was 95% for thyroid, 92% for stomach, 68% for salivary glands, and 67% for orbit. Patients with thyroid and gastric MALTs had better outcome compared with patients with MALTs diagnosed at other sites (P ¼.004). Among those patients who achieved CR, 19% developed disease recurrence (n ¼ 31), chiefly in distant sites or untreated contralateral-paired organs. At the time of disease recurrence, 7 patients (23%) had transformed to diffuse large B-cell lymphoma, 2 of whom died of lymphoma. The 5-year OS rate after treatment failure was 83%. CONCLUSIONS: Patients with localized MALT lymphomas are reported to have excellent clinical outcome after moderate-dose RT, and some are likely cured. In the current study, thyroid and gastric MALTs were found to have significantly less risk of distant recurrence. Despite disease recurrence, the overall survival remains excellent in these patients. Cancer 2010;116:3815-24.

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Section: Discussionmentioning

confidence: 98%

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Goda

Gospodarowicz

Pintilie

et al. 2010

Cancer

188

126

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“…Subconjunctival intralesional injections of interferon-α were tried in a small group of patients, with promising results [119,132]. Recently, a pilot study of C. psittaci-eradicating therapy in patients with ocular MALT lymphoma was undertaken by the Italian group that initially published data on the association between the two entities [133]. Nine patients (five with relapsed or refractory disease) were treated with oral doxycycline (100 mg orally twice a day for 3 weeks).…”

Section: Ocular Adnexa and Lacrimal Glandmentioning

confidence: 99%

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

et al. 2006

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“…Borrelia burgdorferi and Campylobacter jejuni are associated with cutaneous marginal zone B-cell lymphoma and immunoproliferative small intestinal disease, respectively (Cerroni et al, 1997;Lecuit et al, 2004). Recent studies show that Chlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions (Ferreri et al, 2004;Chanudet et al, 2006) and eradication of the organism results in complete regression of the lymphoma in some cases (Ferreri et al, 2005).…”

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confidence: 99%

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chanudet

Adam

et al. 2007

Br J Cancer

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Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (o20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma than non-LPD, although not reaching statistical significance. Mycoplasma pneumoniae DNA was not detected.

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Regression of Ocular Adnexal Lymphoma AfterChlamydia Psittaci–Eradicating Antibiotic Therapy

Cited by 199 publications

References 20 publications

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

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