Regression of Peyer's patches in Galphai2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis

Rig-I−/− mice develop colitis associated with downregulation of Gαi2

“…Previous data have shown that the induction of colitis in Gαi2 -/-mice is associated with the regression of Peyer's patches and disorder of T-cell subsets [16]. The phenotype observed in Rig-I -/-mice is to some degree similar to that observed in Gαi2 -/-mice, suggesting that Gαi2 and Rig-I may function in the same signaling pathway in the development of colitis.…”

“…Gαi2 -/-mice display colitis with 100% penetrance with smaller Peyer's patches and Gαi2 -/-mice also exhibit disorders of the T-cell subsets [16]. These observations suggest that there may be a link between Rig-I and Gαi2.…”

“…Gαi2 is one of the Gα subunits, which has a role in a large variety of cellular and metabolic processes [19][20][21][22][23]. Furthermore, a decreased number of Peyer's patches was also observed in Gαi2 -/-mice [16,17,19]. It is important to emphasize that Peyer's patches provide the first line of defense against pathogen invasion in the intestine.…”

“…Studies on mice with targeted disruption of the genes that regulate the T-cell immune responses have shed light on the development of colitis. For example, mice with targeted disruption of Gαi2 develop colitis with 100% penetrance [16,17]. Gαi2 is regarded as one of the candidate genes for IBD in human, because genetic linkage studies have mapped the Gαi2 gene within an IBD susceptible locus at chromosome 3p21 [18].…”

RIG-I has guts: Identification of a role for RIG-I in colitis development

“…In fact, overproduction of these cytokines resulted in an upregulation of effector T cells and downregulation of naїve T cells, suggesting an important role for Gai2 in the negative regulation of T cell response [4]. Further phenotypic analysis revealed that the number of Peyer's patches, which are the primary site for antigen encounter in the gut and specialised sites for initiation of mucosal immune responses [5], was also decreased in Gai2-deficient mice.…”