Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

DeSouza, Christopher A.; Shapiro, Linda F.; Clevenger, Christopher M.; Dinenno, Frank A.; Monahan, Kevin D.; Tanaka, Hirofumi; Seals, Douglas R.

doi:10.1161/01.cir.102.12.1351

Cited by 748 publications

(542 citation statements)

References 40 publications

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“…5. Intensive physical training may alter endothelial function (Bergholm et al 1999), whereas regular moderate physical training improves endothelial function (DeSouza et al 2000;Higashi et al 1999;Smith DT et al 2003) and attenuates the age-related peripheral vascular function changes in healthy subjects (Beere et al 1999;Martin et al 1991;Vaitkevicius et al 1993).Thus, it is uncertain whether the result of the present study can be extended to the untrained or intensively trained population.…”

Section: Discussionmentioning

confidence: 84%

The physiological response of ankle systolic blood pressure and ankle to brachial index after maximal exercise in athletes is dependent on age

et al. 2005

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The development of sports activities in the over forties has increased the number of middle-aged patients performing heavy-load exercise. The normal response of ankle systolic blood pressure (ASBP) and ankle to brachial index (ABI) to intense exercise is known in young athletes, but little is known for other age groups. Three groups of 21 athletes: <20 (G1), 20-40 (G2), and >40 (G3) years old, respectively, were studied. ASBP and brachial systolic blood pressure (BSBP) were measured simultaneously before and after an incremental maximal cycle ergometer test. Rest ABI was higher in G3 compared to G1 (P<0.001: ANOVA, Bonferroni). Compared to respective resting values, BSBP, at 1 min of recovery, was increased for the three groups of age (P<0.001) whereas ASBP was unchanged for G1 and G2, and significantly increased for G3 (P<0.001). ASBP was significantly higher in G3 than in G1 and G2, ABI was lower in G1 and G2 compared to G3: 0.70+/-0.11, 0.76+/-0.09 and 0.91+/-0.14, respectively. This age-related ABI increase is consistent with the impaired vasodilator capacity observed in aging normal subjects but not with the decrease observed in ABI resting values in epidemiological studies. ABI is higher in older than in younger athletes at rest and after exercise. In aging athletes, aiming to detect mild to moderate arterial lesions, it is likely that normal limits defined in young athletes are not valid.

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Section: Discussionmentioning

confidence: 84%

The physiological response of ankle systolic blood pressure and ankle to brachial index after maximal exercise in athletes is dependent on age

et al. 2005

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“…This relationship between arterial diameter and blood flow velocity (flow-diameter relationship) [29] results as the endothelial cells react to either an increase or decrease in vessel wall shear stress [8,9,10, 30]. The flow-diameter relationship [29] has been reported in the literature related to sedentary individuals [1], older populations [15, 31, 32] and individuals after SCI [4, 10, 16]. Interestingly, it has been reported that there are no significant differences in femoral artery diameter [1, 33] and blood flow velocity [1, 34] in healthy young and older adults when comparing the two limbs, which is contrary to our findings in post-stroke patients.…”

Section: Discussionmentioning

confidence: 99%

Use of Doppler Ultrasound to Assess Femoral Artery Adaptations in the Hemiparetic Limb in People with Stroke

Billinger

Kluding²

2009

Cerebrovasc Dis

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Background: A reduction in physical activity combined with decreased demand for leg oxygen consumption may affect blood flow to the hemiparetic lower extremity after stroke. The purpose of this study was to characterize femoral artery adaptations that occur in the hemiparetic leg in chronic stroke. A secondary goal was to examine intrarater reliability using Doppler ultrasound in people with hemiparesis after stroke. Methods: This descriptive study used a sample of convenience at 2 locations (urban medical center and rural university). Eighteen individuals (68.4 ± 3.7 years of age; 15 males) with chronic stroke (time since stroke: 5.7 ± 1.1 years; 12 with right-side hemiparesis) participated in the study. Femoral artery blood flow, diameter, velocity and vessel wall thickness in the bilateral lower extremities were assessed using Doppler ultrasound. Intrarater reliability was determined for femoral artery diameter and blood flow velocity. Results: Femoral artery blood flow, arterial diameter and blood flow velocity were significantly lower (p < 0.0001) in the hemiparetic limb when compared to the less affected limb. Femoral artery vessel wall thickness was significantly greater (p = 0.002) in the hemiparetic limb. Doppler ultrasound intrarater reliability was strong and significant (intraclass correlation coefficient_3,1 >0.94, p < 0.0001) for femoral artery diameter and blood flow velocity measurements. Conclusion: These data suggest that individuals with chronic stroke demonstrate vascular changes in the femoral artery of the hemiparetic limb.

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“…The endothelium is an important regulator of vascular homeostasis, including control of vascular tone, smooth muscle cell proliferation, platelet aggregation, molecule adhesion, thrombosis and fibrinolysis, and solute transport into and out of the vessel (Vane et al 1990;Cannon 1998). Exercise endurance training beneficially impacts endothelial function and vasodilatory capacity (Clarkson et al 1999;DeSouza et al 2000;Hambrecht et al 2000b). It is thought that this impact is due to nitric oxide release (Kingwell et al 1997;Cannon 1998;Higashi et al 1999b) through repeated bouts of sheer stress via increased blood flow.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise on vasodilatory capacity in endurance- and resistance-trained men

2003

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To determine vasodilatory responsiveness we measured forearm blood flow (FBF) following reactive hyperemia (RH), prior to and following a bout of maximal aerobic exercise in endurance- (n=14) and resistance-trained men (n=10). Both groups were similar in height, body mass, and percentage body fat. Using strain-gauge plethysmography, resting FBF was higher in the resistance-trained group [4.82 (0.84) vs 3.33 (1.17) ml min(-1) 100 ml(-1) of tissue; P<0.05]. However, the resistance-trained group had a 17%-29% lower pre-exercise FBF response to RH for the first 45 s (P<0.05). Following the maximal exercise bout there were no group differences in FBF. Post-exercise FBF was higher compared to pre-exercise values in both the endurance- (P<0.001) and resistance- (P<0.01) trained groups. Endurance-trained men appear to have a greater peak vasodilatory capacity compared to resistance-trained men, and acute maximal exercise increased the vasodilatory capacity in both groups. Acute exercise also equalized the peak vasodilatory response between the endurance- and resistance-trained groups, suggesting the potential for flow-mediated vasodilatation was similar for both groups.

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Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

Cited by 748 publications

References 40 publications

The physiological response of ankle systolic blood pressure and ankle to brachial index after maximal exercise in athletes is dependent on age

The physiological response of ankle systolic blood pressure and ankle to brachial index after maximal exercise in athletes is dependent on age

Use of Doppler Ultrasound to Assess Femoral Artery Adaptations in the Hemiparetic Limb in People with Stroke

Effects of exercise on vasodilatory capacity in endurance- and resistance-trained men

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